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Ovarian Tissue Cryopreservation for Premature Ovarian Failure

Led By Glenn Schattman, MD
Research Sponsored by Weill Medical College of Cornell University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Previous treatment for cancer is acceptable if patient still has ovarian function
Treatment plan that will likely result in premature menopause or premature ovarian failure. This includes patients receiving: Cancer treatment with abdominal pelvic irradiation and/or high dose chemotherapy, Surgery that requires removal of ovaries for medical condition or disease, e.g. Prophylactic oophorectomy in BRCA patients
Screening 3 weeks
Treatment Varies
Follow Up 6 months to a year post surgery, hormone testing will be performed to test ovarian function.
Awards & highlights

Study Summary

This trial is testing a new way to freeze and thaw ovarian tissue so that a woman with premature ovarian failure can have a baby that is genetically related to her.

Who is the study for?
This trial is for premenopausal females aged 0-45 who may lose their ovarian function due to cancer treatments or need their ovaries removed. It's also for those who can't or don't want to freeze eggs or embryos but are medically cleared for surgery.Check my eligibility
What is being tested?
The study tests the effectiveness of freezing and thawing ovarian tissue, as well as maturing immature eggs in a lab setting. This could help women at risk of early ovarian failure have genetically related children in the future.See study design
What are the potential side effects?
Potential side effects include those associated with surgical removal of ovaries and high dose chemotherapy, such as pain, infection risks from surgery, nausea, hair loss, fatigue from chemo, and fertility-related hormonal changes.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
I have had cancer treatment but my ovaries are still functioning.
My treatment may cause early menopause due to radiation, chemotherapy, or surgery.
I am not planning to freeze my eggs or embryos for future use.
I am a woman aged 0-45 and have not gone through menopause.
I am cleared by a doctor to have surgery.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months to a year post surgery, hormone testing will be performed to test ovarian function.
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months to a year post surgery, hormone testing will be performed to test ovarian function. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures

Trial Design

1Treatment groups
Experimental Treatment
Group I: Use of high dose chemotherapyExperimental Treatment1 Intervention
Use of chemotherapy without removal of the disease ovary.

Find a Location

Who is running the clinical trial?

Weill Medical College of Cornell UniversityLead Sponsor
1,054 Previous Clinical Trials
1,316,345 Total Patients Enrolled
Glenn Schattman, MDPrincipal InvestigatorWeill Medical College of Cornell University
4 Previous Clinical Trials
72 Total Patients Enrolled

Media Library

Use of high dose chemotherapy Clinical Trial Eligibility Overview. Trial Name: NCT01558544 — N/A
Cancer Research Study Groups: Use of high dose chemotherapy
Cancer Clinical Trial 2023: Use of high dose chemotherapy Highlights & Side Effects. Trial Name: NCT01558544 — N/A
Use of high dose chemotherapy 2023 Treatment Timeline for Medical Study. Trial Name: NCT01558544 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the cap for participants in this research?

"Affirmative. Clinicaltrials.gov attests that this experiment, which began recruiting on April 1st 1997, is still actively looking for participants. In total, a hundred individuals must be sourced from one medical site."

Answered by AI

Is enrollment into this clinical research still open?

"Yes, clinicaltrials.gov confirms that this medical trial has been ongoing since April 1st 1997 and was most recently updated on January 26th 2022 - indicating the active recruitment of participants."

Answered by AI
~16 spots leftby Oct 2025