Ovarian Tissue Cryopreservation for Premature Ovarian Failure
Trial Summary
What is the purpose of this trial?
The study hopes to contribute to the development of technologies of ovarian tissue freezing-thawing and in vitro maturation of immature eggs such that a person at risk for premature ovarian failure might be able to conceive a genetically related child.
Do I need to stop my current medications for this trial?
The trial protocol does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment Cryopreservation of Ovarian Tissue for Premature Ovarian Failure?
Research shows that cryopreservation of ovarian tissue can successfully restore ovarian function, as demonstrated in a case where ovarian function was restored after transplantation of tissue that had been cryopreserved for 10 years. This suggests that the treatment can be effective in preserving ovarian function in patients at risk of premature ovarian failure.12345
Is ovarian tissue cryopreservation safe for humans?
Ovarian tissue cryopreservation has been used for over two decades, with thousands of women undergoing the procedure worldwide. While fewer than 500 patients have had their tissue transplanted, nearly all of them regained ovarian function, suggesting the procedure is generally safe. However, there are still risks, such as low follicular survival after thawing and the potential reintroduction of disease.16789
How does ovarian tissue cryopreservation differ from other treatments for premature ovarian failure?
Ovarian tissue cryopreservation is unique because it involves freezing ovarian tissue to preserve fertility, which can later be transplanted to restore ovarian function. Unlike other treatments that may focus on hormone replacement, this method directly preserves and potentially restores the natural ovarian function and fertility.134510
Research Team
Glenn Schattman, MD
Principal Investigator
Weill Medical College of Cornell University
Eligibility Criteria
This trial is for premenopausal females aged 0-45 who may lose their ovarian function due to cancer treatments or need their ovaries removed. It's also for those who can't or don't want to freeze eggs or embryos but are medically cleared for surgery.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Preoperative Assessment
Preoperative sonographic assessment of ovaries, blood sampling, and infectious disease testing
Surgery
Laparotomy or laparoscopy for removal and cryopreservation of ovarian tissue
Postoperative Care
Routine postoperative care following ovarian tissue removal
Follow-up
Hormone testing and evaluation of ovarian reserve 6 months to 1 year post-surgery
Treatment Details
Interventions
- Cryopreservation of Ovarian Tissue
Find a Clinic Near You
Who Is Running the Clinical Trial?
Weill Medical College of Cornell University
Lead Sponsor