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Ovarian Tissue Cryopreservation for Premature Ovarian Failure

N/A
Recruiting
Led By Glenn Schattman, MD
Research Sponsored by Weill Medical College of Cornell University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Treatment plan that will likely result in premature menopause or premature ovarian failure. This includes patients receiving: Cancer treatment with abdominal pelvic irradiation and/or high dose chemotherapy, Surgery that requires removal of ovaries for medical condition or disease, e.g. Prophylactic oophorectomy in BRCA patients
Patient is unable or unwilling to pursue fertility preservation by freezing oocytes or embryos
Must not have
Patients who have not received medical clearance from their physicians to undergo surgery
Patients already experiencing menopause
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months to a year post surgery, hormone testing will be performed to test ovarian function.
Awards & highlights

Summary

This trial is testing a new way to freeze and thaw ovarian tissue so that a woman with premature ovarian failure can have a baby that is genetically related to her.

Who is the study for?
This trial is for premenopausal females aged 0-45 who may lose their ovarian function due to cancer treatments or need their ovaries removed. It's also for those who can't or don't want to freeze eggs or embryos but are medically cleared for surgery.Check my eligibility
What is being tested?
The study tests the effectiveness of freezing and thawing ovarian tissue, as well as maturing immature eggs in a lab setting. This could help women at risk of early ovarian failure have genetically related children in the future.See study design
What are the potential side effects?
Potential side effects include those associated with surgical removal of ovaries and high dose chemotherapy, such as pain, infection risks from surgery, nausea, hair loss, fatigue from chemo, and fertility-related hormonal changes.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My treatment may cause early menopause due to radiation, chemotherapy, or surgery.
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I am not planning to freeze my eggs or embryos for future use.
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I am a woman aged 0-45 and have not gone through menopause.
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I am cleared by a doctor to have surgery.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I haven't been cleared by my doctor for surgery.
Select...
I have gone through menopause.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months to a year post surgery, hormone testing will be performed to test ovarian function.
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months to a year post surgery, hormone testing will be performed to test ovarian function. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
CRYOPRESERVATION OF OVARIAN TISSUE FOR POTENTIAL IN VITRO MATURATION OR AUTOLOGOUS TRANSPLANTATION

Trial Design

1Treatment groups
Experimental Treatment
Group I: Use of high dose chemotherapyExperimental Treatment1 Intervention
Use of chemotherapy without removal of the disease ovary.

Find a Location

Who is running the clinical trial?

Weill Medical College of Cornell UniversityLead Sponsor
1,064 Previous Clinical Trials
1,318,886 Total Patients Enrolled
Glenn Schattman, MDPrincipal InvestigatorWeill Medical College of Cornell University
4 Previous Clinical Trials
72 Total Patients Enrolled

Media Library

Use of high dose chemotherapy Clinical Trial Eligibility Overview. Trial Name: NCT01558544 — N/A
Cancer Research Study Groups: Use of high dose chemotherapy
Cancer Clinical Trial 2023: Use of high dose chemotherapy Highlights & Side Effects. Trial Name: NCT01558544 — N/A
Use of high dose chemotherapy 2023 Treatment Timeline for Medical Study. Trial Name: NCT01558544 — N/A
~13 spots leftby Oct 2025
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