QL Block for Pain, Postoperative

Phase-Based Progress Estimates
3
Effectiveness
3
Safety
The University of Texas Health Science Center at Houston, Houston, TX
Pain, Postoperative
QL - Drug
Eligibility
18+
Female
What conditions do you have?
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Study Summary

The purpose of this study is to compare quality of recovery as well as peri-operative systemic opiates use and pain scores in patients undergoing laparoscopic or robotic hysterectomy when local anesthetic versus Quadratus Lumborum nerve block (QL-2) is added to the standard pain management.

Treatment Effectiveness

Effectiveness Progress

3 of 3
This is further along than 93% of similar trials

Study Objectives

5 Primary · 2 Secondary · Reporting Duration: 24 hours after anesthesia

24 hours after anesthesia
Emotional state as assessed by the Quality of Recovery (QOR-40) validated questionnaire
Pain as assessed by the Quality of Recovery (QOR-40) validated questionnaire
Physical comfort as assessed by the Quality of Recovery (QOR-40) validated questionnaire
Physical independence as assessed by the Quality of Recovery (QOR-40) validated questionnaire
Psychological support as assessed by the Quality of Recovery (QOR-40) validated questionnaire
6 weeks post surgery
Amount of oral morphine consumed measured in morphine milliequivalents (OME)
Pain at rest as assessed by the visual analog scale

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Trial Design

2 Treatment Groups

Local Anesthesia at incision site
1 of 2
QL Block
1 of 2
Active Control
Experimental Treatment

76 Total Participants · 2 Treatment Groups

Primary Treatment: QL Block · No Placebo Group · Phase 4

QL BlockExperimental Group · 2 Interventions: QL, Sham Local · Intervention Types: Drug, Drug
Local Anesthesia at incision siteActiveComparator Group · 2 Interventions: Sham QL, Local anesthesia at incision site · Intervention Types: Drug, Drug

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 24 hours after anesthesia

Trial Background

Prof. Randa Jalloul, Associate Professor
Principal Investigator
The University of Texas Health Science Center, Houston
Closest Location: The University of Texas Health Science Center at Houston · Houston, TX
Photo of Houston  1Photo of Houston  2Photo of Houston  3
2008First Recorded Clinical Trial
9 TrialsResearching Pain, Postoperative
190 CompletedClinical Trials

Eligibility Criteria

Age 18+ · Female Participants · 3 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You have a ASA physical status of 1, 2, or 3.
You are planning to have a laparoscopic or robotic hysterectomy.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.