Doxepin for Hives

Phase-Based Progress Estimates
2
Effectiveness
3
Safety
SUNY Upstate Medical University, Syracuse, NYHivesDoxepin - Drug
Eligibility
18 - 65
All Sexes
What conditions do you have?
Select

Study Summary

This trial compares the effectiveness of doxepin versus diphenhydramine in treating isolated urticaria in the emergency department.

Treatment Effectiveness

Effectiveness Progress

2 of 3
This is further along than 85% of similar trials

Similar Trials

1
Dobutamine + Goal-Directed Fluid Therapy
1
High Calcium, Low Sodium (HCLS) Crystalloid Therapy
2
Ligelizumab

Study Objectives

1 Primary · 0 Secondary · Reporting Duration: 1 hour after med administration, 2 hours after administration, and prior to discharge

Hour 2
Improvement of urticaria

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Similar Trials

1
Dobutamine + Goal-Directed Fluid Therapy
2
High Calcium, Low Sodium (HCLS) Crystalloid Therapy
3
Ligelizumab

Side Effects for

Temazepam
13%dry mouth
4%sedation
This histogram enumerates side effects from a completed 2010 Phase 4 trial (NCT00465972) in the Temazepam ARM group. Side effects include: dry mouth with 13%, sedation with 4%.

Trial Design

2 Treatment Groups

Diphenhydramine
1 of 2
Doxepin
1 of 2

Active Control

Experimental Treatment

160 Total Participants · 2 Treatment Groups

Primary Treatment: Doxepin · No Placebo Group · Phase 3

Doxepin
Drug
Experimental Group · 1 Intervention: Doxepin · Intervention Types: Drug
Diphenhydramine
Drug
ActiveComparator Group · 1 Intervention: Diphenhydramine · Intervention Types: Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Doxepin
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 1 hour after med administration, 2 hours after administration, and prior to discharge

Who is running the clinical trial?

State University of New York - Upstate Medical UniversityLead Sponsor
157 Previous Clinical Trials
26,594 Total Patients Enrolled

Eligibility Criteria

Age 18 - 65 · All Participants · 4 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have been diagnosed with a sudden outbreak of hives (bumps on the skin).
You need to take medicine like antihistamines to relieve your symptoms.
References

Frequently Asked Questions

Are we seeking volunteers who meet the age requirement for this experiment?

"For this particular clinical trial, only patients aged 18 to 65 can enroll. If you are not within this age range, there are 16 other clinical trials you may be eligible for." - Anonymous Online Contributor

Unverified Answer

How many research subjects are you enrolling in this investigation?

"Yes, you are correct. The clinical trial is still recruiting patients and was last updated on 5/17/2022. This study is looking for 160 participants from a single site." - Anonymous Online Contributor

Unverified Answer

Are there negative consequences associated with Doxepin?

"Doxepin has received a safety score of 3. This means that while it is still in clinical trials, there is evidence of its efficacy and multiple rounds of data supporting its safety." - Anonymous Online Contributor

Unverified Answer

What medical prerequisites are necessary in order to enroll in this research project?

"Researchers are looking for around 160 adult patients that have urticaria in order to study the long-term effects of the condition." - Anonymous Online Contributor

Unverified Answer

How does Doxepin's trial history compare to similar drugs?

"As of now, there are 34 separate clinical trials researching Doxepin. Of these, 9 have progressed to Phase 3. though most of the Doxepin studies are based in Birmingham, Alabama, there are 801 total locations running these experiments." - Anonymous Online Contributor

Unverified Answer

For what conditions is Doxepin most commonly prescribed?

"Doxepin is often given to patients suffering from bronchitis, but it can also provide relief for conditions such as chronic coughing, difficulty sleeping, and skin inflammation." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

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