Treatment - Active for Asthma

Phase-Based Progress Estimates
Children's Hospital of New York Medical Center, New York, NYAsthma+1 MoreAzithromycin - Drug
18 - 60
All Sexes
What conditions do you have?

Study Summary

This trial will compare the 5-day outcome of preschool children presenting to an Emergency Department (ED) with an acute, severe wheezing episode and treated with either once daily oral Azithromycin (12 mg/kg/day for 5 days) or placebo.

Eligible Conditions
  • Asthma
  • Wheezing

Treatment Effectiveness

Effectiveness Progress

2 of 3
This is further along than 85% of similar trials

Study Objectives

1 Primary · 3 Secondary · Reporting Duration: 72 hours after randomization

21 days after randomization
Development of Azithromycin resistant organisms
Day 5
72 hours after randomization
Length of Stay

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Trial Design

2 Treatment Groups

Treatment - Active
1 of 2
Treatment - Placebo
1 of 2

Active Control

Non-Treatment Group

1476 Total Participants · 2 Treatment Groups

Primary Treatment: Treatment - Active · Has Placebo Group · Phase 3

Treatment - Active
ActiveComparator Group · 1 Intervention: Azithromycin · Intervention Types: Drug
Treatment - Placebo
PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 72 hours after randomization

Who is running the clinical trial?

University of ArizonaLead Sponsor
468 Previous Clinical Trials
151,735 Total Patients Enrolled
8 Trials studying Asthma
1,986 Patients Enrolled for Asthma
University of UtahOTHER
1,008 Previous Clinical Trials
1,785,906 Total Patients Enrolled
5 Trials studying Asthma
175,069 Patients Enrolled for Asthma
Emory UniversityOTHER
1,523 Previous Clinical Trials
2,712,043 Total Patients Enrolled
11 Trials studying Asthma
1,639 Patients Enrolled for Asthma
Morgan Stanley Children's HospitalOTHER
4 Previous Clinical Trials
9,840 Total Patients Enrolled
University of PittsburghOTHER
1,634 Previous Clinical Trials
16,306,389 Total Patients Enrolled
14 Trials studying Asthma
3,582 Patients Enrolled for Asthma
Children's Hospital and Health System Foundation, WisconsinOTHER
53 Previous Clinical Trials
94,673 Total Patients Enrolled
2 Trials studying Asthma
136 Patients Enrolled for Asthma
Children's Hospital Medical Center, CincinnatiOTHER
763 Previous Clinical Trials
5,420,363 Total Patients Enrolled
15 Trials studying Asthma
1,385 Patients Enrolled for Asthma
Children's Hospital of PhiladelphiaOTHER
661 Previous Clinical Trials
7,853,120 Total Patients Enrolled
13 Trials studying Asthma
3,303 Patients Enrolled for Asthma
Boston Children's HospitalOTHER
718 Previous Clinical Trials
5,322,954 Total Patients Enrolled
17 Trials studying Asthma
6,305 Patients Enrolled for Asthma
Fernando D Martinez, MDPrincipal InvestigatorUniversity of Arizona
2 Previous Clinical Trials
1,429 Total Patients Enrolled
2 Trials studying Asthma
1,429 Patients Enrolled for Asthma
Kurt Denninghoff, MDPrincipal InvestigatorUniversity of Arizona
1 Previous Clinical Trials
32 Total Patients Enrolled
Charlie Casper, PhDPrincipal InvestigatorUniversity of Utah

Eligibility Criteria

Age 18 - 60 · All Participants · 3 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have a breathing difficulty score (PRAM) of 4 or more during your emergency room visit.
You are experiencing wheezing when you exhale, which was confirmed by a doctor or nurse when you arrived at the emergency room.

Frequently Asked Questions

What is the cap for participators in this clinical trial?

"Correct. The information hosted on verifies that this medicinal experiment, which was first posted on September 22nd 2021, is still actively recruiting participants across 6 sites for a total of 1476 patients." - Anonymous Online Contributor

Unverified Answer

Does Treatment - Active meet the regulatory standards set forth by the FDA?

"The team at Power rated the safety of Treatment - Active as a 3 due to prior clinical evidence supporting efficacy, in addition to multiple rounds of data demonstrating its safety." - Anonymous Online Contributor

Unverified Answer

Does the protocol for this experiment require participants to be over 25 years of age?

"For this clinical study, only patients falling within the 18-month to 5 year age range are eligible. 186 trials target children younger than 18 months while 392 studies focus on seniors above 65 years of age." - Anonymous Online Contributor

Unverified Answer

Is there a possibility for me to participate in this experiment?

"This medical study is seeking 1476 toddlers and children with asthma. The patient's age must be between 18 months old to 5 years of age, they need to have exhibited expiratory wheezing during their emergency department visit, and a Pediatric Respiratory Assessment Measurement score higher than or equal to 4 at any time during the ED stay." - Anonymous Online Contributor

Unverified Answer

Are there any vacancies left in this trial for participants?

"Data hosted on verify that this medical trial is actively looking for participants, having been originally published on September 22nd 2021 and updated most recently on November 30th 2022." - Anonymous Online Contributor

Unverified Answer

How many medical centers are currently hosting this clinical trial?

"Patients are being admitted to the Children's Hospital of New York Medical Center in Manhattan, Cincinnati Children's Hospital Medical Centre, and Boston Children's Hospital. Additionally, 6 more medical centres will be incorporated into this trial." - Anonymous Online Contributor

Unverified Answer

Has Treatment - Active been evaluated in any prior investigations?

"Presently, there are 55 active clinical trials investigating Treatment - Active. Of which 18 of these inquiries have advanced to Phase 3 testing. Though most studies are held in Albuquerque, New Mexico, altogether 694 sites accommodate this treatment's research." - Anonymous Online Contributor

Unverified Answer

What medical conditions have been demonstrated to respond positively to Treatment - Active?

"Administration of Treatment - Active is a typical remedy for genital ulcer disease (GUD). Moreover, it can help treat chlamydia in adults and cervicitis." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.