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VRT Care for Vertigo (AVERT Trial)

N/A
Waitlist Available
Led By David Newman-Toker, MD, PhD
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
RECENT ONSET: symptoms AND signs* appear to be new or markedly worse in the past month
RELEVANT EXAM SIGNS*: pathologic nystagmus (spontaneous, gaze-evoked, or positional) by bedside VOG testing OR pathologic ataxia (gait, trunk, stance, limbs) by bedside ataxia examination.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months after last patient/last visit
Awards & highlights

AVERT Trial Summary

This trial will compare the accuracy of diagnoses and initial management decisions for emergency department patients with a chief symptom of vertigo or dizziness when using video-oculography (VOG) versus standard care.

Eligible Conditions
  • Vertigo
  • Dizziness

AVERT Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You are experiencing new or worsening symptoms and signs within the last month.
Select...
You have been experiencing feelings of dizziness, unsteadiness or vertigo as defined by medical experts.

AVERT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months after last patient/last visit
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months after last patient/last visit for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Index Visit Total Diagnostic Utilization Costs (all, VRT vs. SOC)
Odds of Short-Term Serious Medical Events (SMEs) after Misdiagnosis (SOC arm only, correct vs. incorrect diagnoses)
Six-Category Diagnosis Accuracy (all, VRT vs. SOC)
Secondary outcome measures
Expert VOG Six-Category Diagnosis Accuracy (all, expert VOG vs. SOC)
Stroke-No Stroke Diagnosis Accuracy (all, VRT vs. SOC)

AVERT Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: VRT CareExperimental Treatment1 Intervention
Patients randomized to VRT (VOG-guided Rapid Triage) care will have an algorithm-determined patient-specific diagnosis and treatment pathway in the emergency department. Patients will complete a 1 week in-person follow up and a 1 and 6 month phone follow up.
Group II: Standard of Care (SOC)Active Control1 Intervention
Patients randomized to Standard of Care will undergo usual emergency department care without revealing results of VOG testing. Patients will complete a 1 week in-person follow up and a 1 and 6 month phone follow up.
Group III: ObservationalActive Control1 Intervention
Patients who signed an informed consent but did not meet inclusion/exclusion criteria and don't randomize will enter a parallel track observational sub-study with limited 1 and 6 month phone follow-up.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
VRT Care
2017
N/A
~200

Find a Location

Who is running the clinical trial?

GN OtometricsUNKNOWN
1 Previous Clinical Trials
100 Total Patients Enrolled
National Institute on Deafness and Other Communication Disorders (NIDCD)NIH
324 Previous Clinical Trials
177,923 Total Patients Enrolled
5 Trials studying Vertigo
88,357 Patients Enrolled for Vertigo
Johns Hopkins UniversityLead Sponsor
2,239 Previous Clinical Trials
14,816,331 Total Patients Enrolled
3 Trials studying Vertigo
192 Patients Enrolled for Vertigo

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the prevalence of this experiment in US medical institutions?

"This trial is inviting participants to enrol at Mt. Sinai Medical Center in New york, Massachusetts General Hospital in Boston, and University of Michigan in Ann Arbor. Additionally, other five sites are also participating."

Answered by AI

Are there any openings remaining in this research initiative?

"At present, clinicaltrials.gov states that this study is not presently recruiting patients, despite having been initially posted on December 4th 2017 and most recently edited on August 11th 2022. Nevertheless, there are still 219 other trials actively looking for participants to participate in their research."

Answered by AI

What aims does this research endeavor hope to accomplish?

"This medical trial's primary outcome is to measure total diagnostic utilization costs over a 6 month period from the conclusion of treatment. Secondary outcomes include assessing algorithm-only VRT diagnosis accuracy compared to standard of care, preventing six-category diagnoses errors in comparison to SOC, and gauging VRT versus MRI stroke/no stroke diagnosis accuracy (VRT arm only)."

Answered by AI
~27 spots leftby Mar 2025