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Lipid Regulating Agent

Active for Huntington's Disease

Phase 2
Waitlist Available
Led By Neal Hermanowicz, MD
Research Sponsored by University of California, Irvine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to 3 and 6 months.
Awards & highlights

Study Summary

The purpose of this research study is to study the safety and efficacy of fenofibrate, an FDA-approved drug for high cholesterol and/or elevated triglycerides (fats), as a treatment for Huntington's disease (HD). Subjects who meet the entry criteria will be randomized (3:1) to either 145mg of fenofibrate or placebo.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to 3 and 6 months.
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to 3 and 6 months. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in PGC-1alpha Protein Abundance.
Change in PGC-1alpha RNA Expression
Secondary outcome measures
Change in Fenofibric Acid Level.
Change in Functional Assessment Scores
Change in Montreal Cognitive Assesment Score.
+2 more

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: ActiveActive Control1 Intervention
Group II: PlaceboPlacebo Group1 Intervention

Find a Location

Who is running the clinical trial?

University of California, IrvineLead Sponsor
544 Previous Clinical Trials
1,923,033 Total Patients Enrolled
Neal Hermanowicz, MDPrincipal InvestigatorUniversity of California, Irvine
Leslie Thompson, PhDStudy DirectorUniversity of California, Irvine

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Safety and Efficacy of Fenofibrate as a Treatment for Huntington's Disease
Leslie Thompson 2017. "Safety and Efficacy of Fenofibrate as a Treatment for Huntington's Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03515213.
~1 spots leftby Apr 2025
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