Popular Trials
Monoclonal Antibodies
Faricimab for Diabetic Macular Edema
This trial is designed to see if faricimab is an effective treatment for diabetic macular edema in underrepresented patients who have not yet received treatment. The study population will consist of participants who self-identify as Black/African American, Hispanic/Latino American, or Native American/Alaska Native/Native Hawaiian or other Pacific Islander.
Gene Therapy
RGX-314 Gene Therapy for Diabetic Retinopathy
This trial is testing a new gene therapy treatment for diabetic retinopathy, a progressive complication of diabetes that is a leading cause of vision loss. The new treatment is being developed as a potential one-time treatment that may provide a longer duration of therapeutic effect and intervene at an earlier stage of the disease.
Nonsteroidal Anti-inflammatory Drug
Episcleral Celecoxib for Macular Edema
This trial is testing a treatment called Episcleral Celecoxib, which is applied to the outer layer of the eye. It is aimed at patients with macular edema and other inflammatory eye conditions. The drug works by reducing swelling and preventing harmful blood vessel growth in the eye. The main goal is to see if the treatment is safe and if it can improve vision by reducing inflammation.
Popular Filters
Trials for Diabetic Macular Edema Patients
Monoclonal Antibodies
Foselutoclax for Diabetic Macular Edema
This trial is testing foselutoclax, a new drug, in patients with Diabetic Macular Edema who haven't responded to other treatments. The drug works by blocking a protein to reduce eye swelling and improve vision.
Corticosteroid
ILUVIENĀ® Implant for Diabetic Macular Edema
This trial is testing whether or not a new treatment for DME is better than the standard treatment. It will enroll patients who have not had any DME treatments for the past 12 months, and compare the new treatment to the standard treatment.
Monoclonal Antibodies
PDS with Ranibizumab vs. Intravitreal Ranibizumab for Diabetic Macular Edema
This trial will compare the effects of two different ways of delivering a drug to treat diabetic macular edema. One group will receive the drug every four weeks, and the other group will receive the drug every 24 weeks.
Trials for DME Patients
Monoclonal Antibodies
Foselutoclax for Diabetic Macular Edema
This trial is testing foselutoclax, a new drug, in patients with Diabetic Macular Edema who haven't responded to other treatments. The drug works by blocking a protein to reduce eye swelling and improve vision.
Corticosteroid
ILUVIENĀ® Implant for Diabetic Macular Edema
This trial is testing whether or not a new treatment for DME is better than the standard treatment. It will enroll patients who have not had any DME treatments for the past 12 months, and compare the new treatment to the standard treatment.
Monoclonal Antibodies
PDS with Ranibizumab vs. Intravitreal Ranibizumab for Diabetic Macular Edema
This trial will compare the effects of two different ways of delivering a drug to treat diabetic macular edema. One group will receive the drug every four weeks, and the other group will receive the drug every 24 weeks.
Phase 3 Trials
Monoclonal Antibodies
PDS with Ranibizumab vs. Intravitreal Ranibizumab for Diabetic Macular Edema
This trial will compare the effects of two different ways of delivering a drug to treat diabetic macular edema. One group will receive the drug every four weeks, and the other group will receive the drug every 24 weeks.
Vamikibart for Uveitic Macular Edema
This trial is testing vamikibart, a medication that may reduce eye swelling caused by inflammation. It focuses on people with uveitic macular edema, aiming to improve their condition by calming the inflammation in their eyes.
Anti-VEGF
Aflibercept for Age-Related Macular Degeneration and Diabetic Macular Edema
This trial is testing a new drug called aflibercept 8 mg on people with nAMD and DME who have already used other medications. The goal is to see how safe and effective the drug
Trials With No Placebo
Monoclonal Antibodies
Foselutoclax for Diabetic Macular Edema
This trial is testing foselutoclax, a new drug, in patients with Diabetic Macular Edema who haven't responded to other treatments. The drug works by blocking a protein to reduce eye swelling and improve vision.
Corticosteroid
ILUVIENĀ® Implant for Diabetic Macular Edema
This trial is testing whether or not a new treatment for DME is better than the standard treatment. It will enroll patients who have not had any DME treatments for the past 12 months, and compare the new treatment to the standard treatment.
Frequently Asked Questions
Introduction to macular edema
What are the top hospitals conducting macular edema research?
In the realm of cutting-edge clinical trials addressing macular edema, several hospitals are at the forefront of medical research. In Boston, Ophthalmic Consultants of Boston leads the way with seven active trials dedicated to this condition and a remarkable 31 completed studies throughout their history. Their commitment to innovation started with their first recorded macular edema trial in 2004. Further west in Reno, Sierra Eye Associates is making significant contributions as well, having initiated their first trial in 2015 and currently conducting seven ongoing macular edema trials. Meanwhile, Cumberland Valley Retina Consultants in Hagerstown has also stepped up to the plate by undertaking seven active clinical trials for this condition since recording their inaugural study in 2017.
Additionally contributing towards advancing our understanding of macular edema is National Ophthalmic Research Institute located in Fort Myers where they presently have six ongoing investigations alongside previous twenty experiments conducted over years from initiating trail investigation on such conditions when it was founded back until2004.On top of all these efforts,Piedmont Eye Center situated within Lynchburg recently joined ranks pioneering themselves three years ago with earliest documented experimentation tracing back only two years ago-2018;nevertheless playing crucial role adding six current clinical tests upon prior total eleven examinations under its belt.
These esteemed institutions collectively embody true dedication to finding effective treatments for individuals impacted by macular edema. Each initiative brings us closer to unraveling the complexities surrounding this condition and offers hope for improved outcomes and quality of life for patients worldwide
Which are the best cities for macular edema clinical trials?
When it comes to macular edema clinical trials, several cities have emerged as leaders in research and innovation. Austin, Texas stands out with 21 active trials focusing on treatments like PDS Implant Pre-Filled with 100 mg/mL Ranibizumab, Faricimab, KSI-301, and more. Hagerstown, Maryland follows closely behind with 18 ongoing studies exploring similar interventions such as PDS Implant Pre-Filled with 100 mg/mL Ranibizumab and RO7200220. San Antonio, Texas is also a prominent location for macular edema clinical trials, offering 16 active studies investigating treatments like PDS Implant Pre-Filled with 100 mg/mL Ranibizumab and KSI-301. These cities provide individuals affected by macular edema access to cutting-edge treatment options through their involvement in these important research endeavors.
Which are the top treatments for macular edema being explored in clinical trials?
Macular edema, a condition affecting the central vision of the eye, has spurred numerous clinical trials in search of effective treatments. Faricimab emerges as one of the top contenders, currently undergoing two active trials and having been listed since 2016 with a total of ten macular edema trials to date. Another promising treatment is the PDS Implant Pre-Filled with 100 mg/mL Ranibizumab, which also shows potential with two ongoing trials and an initial listing in 2019. Additionally, KSI-301 joins this lineup, participating in two active trials and four all-time macular edema studies since its introduction in 2018. These exploratory efforts bring us closer to finding innovative solutions for individuals suffering from macular edemaāoffering renewed hope for improved vision outcomes.
What are the most recent clinical trials for macular edema?
Several recent clinical trials are shedding light on potential advancements in the treatment of macular edema. In one Phase 2 trial, 4D-150 is being investigated for its efficacy in addressing this condition. Another Phase 2 study focuses on the foselutoclax arm and its impact on macular edema. Similarly, a Phase 2 trial is examining the effects of B1: OXU-001 at a mid dose level. Furthermore, another promising approach involves exploring different dosage levels in both Phase 1 and Phase 2 studies to determine their effectiveness against macular edema. Additionally, a separate Phase 4 trial investigates cataract surgery with Dextenza alongside a less frequent gtt regimen as an intervention for macular edema treatment optimization. These exciting endeavors hold promise for improving outcomes and providing relief to individuals suffering from macular edema.
What macular edema clinical trials were recently completed?
Recent clinical trials have made significant progress in the field of macular edema, a condition affecting the central part of the retina. Among these trials, Curacle Co., Ltd.'s study on multiple doses of CU06-1004 concluded successfully in July 2021. Unity Biotechnology, Inc.'s trial for UBX1325 reached completion in June 2021, while Ocuphire Pharma, Inc.'s investigation into APX3330 wrapped up in April 2021. In pursuit of effective treatments for macular edema, researchers from various organizations such as Hoffmann-La Roche and Novartis Pharmaceuticals have also conducted trials on Faricimab (completed March/December 2021), AXT107 (completed December 2020), MHU650 (completed December 2020), KSI-301 (completed September 2020), Aflibercept (completed May 2020), AR-13503 (completed June 2019), and LKA651 (completed May 2019). These collective efforts hold promise for improving outcomes for individuals affected by this vision-threatening condition.