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Local Anesthetic

Liposomal Bupivacaine (EXPAREL®)/Bupivacaine for Thoracic Surgery

Q: What type of pain is Liposomal Bupivacaine (EXPAREL®)/Bupivacaine most effective against?

<p>Liposomal Bupivacaine (<a href="https://www.withpower.com/clinical-trials/exparel">EXPAREL</a>®)/Bupivacaine is the standard treatment for permphigus and can also be used to effectively manage acute nonspecific tenosynovitis, general anesthesia, and labour.</p>

Phase 2

Waitlist Available

Led By Poovendran Saththasivam, MD

Research Sponsored by The Guthrie Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up at end of surgery

Awards & highlights

Study Summary

This trial is testing whether it's better to have a single shot of long-acting local anesthetic or a catheter infusion of local anesthetic during VAT surgery.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 72 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 72 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 72 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Numerical Rated Pain Scale (NRP)

Secondary outcome measures

Adverse events frequency

Incentive spirometry changes from preoperative baseline to 3 days post-operative

Length of hospital stay

+4 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Single Shot Liposomal Bupivacaine (EXPAREL®)/BupivacaineExperimental Treatment1 Intervention

Single Shot Liposomal Bupivacaine (EXPAREL®)/Bupivacaine for erector spinae block as local anesthetic

Group II: Continuous catheter infusion ropivacaineActive Control1 Intervention

Ropivacaine (0.5% bolus followed by 0.2% infusion) using a continuous catheter for erector spinae plane block as local anesthetic

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

The Guthrie ClinicLead Sponsor

25 Previous Clinical Trials

1,794 Total Patients Enrolled

Poovendran SaththasivamLead Sponsor

Poovendran Saththasivam, MDPrincipal InvestigatorThe Guthrie Clinic

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many test subjects are participating in this experiment?

"That is accurate, the online information from clinicaltrials.gov outlines that this experiment is currently looking for participants. This trial was originally advertised on December 10th 2020 and updated December 14th 2021. They are hoping to enroll 74 individuals at a single site."

Answered by AI

What type of pain is Liposomal Bupivacaine (EXPAREL®)/Bupivacaine most effective against?

"Liposomal Bupivacaine (EXPAREL®)/Bupivacaine is the standard treatment for permphigus and can also be used to effectively manage acute nonspecific tenosynovitis, general anesthesia, and labour."

Answered by AI

Does the FDA permit clinicians to use Liposomal Bupivacaine (EXPAREL®)/Bupivacaine?

"There is some clinical data supporting the safety of Liposomal Bupivacaine (EXPAREL®)/Bupivacaine, but none yet for efficacy. This earns it a score of 2."

Answered by AI

Are there any available positions for participants in this trial?

"That is correct. The clinical trial was posted on December 10th, 2020 and updated most recently on December 14th, 2021. They are looking for 74 participants at 1 location."

Answered by AI

Could you please summarize the other research done on Liposomal Bupivacaine (EXPAREL®)/Bupivacaine?

"As of right now, 188 different clinical trials are underway to research Liposomal Bupivacaine (EXPAREL®)/Bupivacaine. Out of those 188 trials, 37 are in Phase 3. Most of the said trials are based in Germantown, Tennessee; however, there are a total of 250 locations running these types of trials."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Local Anesthetic as Single Shot Versus Catheter in Patients Undergoing Video Assisted Thoracoscopic Surgery

Poovendran Saththasivam 2020. "Local Anesthetic as Single Shot Versus Catheter in Patients Undergoing Video Assisted Thoracoscopic Surgery". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04559347.