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EXPAREL vs Lidocaine for Pleural Cancer

Phase 2

Recruiting

Led By Horiana Grosu, MD

Research Sponsored by M.D. Anderson Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age > 18

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up through study completion, an average of 1 year

Awards & highlights

Study Summary

This trial compares the effect of two local anesthetics, EXPAREL and lidocane, on patients undergoing pleuroscopy with pleural biopsy and indwelling pleural catheter placement. The goal is to see which anesthetic makes patients more comfortable.

Who is the study for?

This trial is for adults over 18 referred for pleuroscopy with biopsies and chest procedures, who can consent to treatment. It's not suitable for those allergic to EXPAREL or lidocaine, pregnant individuals, patients needing pleurodesis, or those with advanced liver disease.Check my eligibility

What is being tested?

The study compares the effectiveness of two local anesthetics—EXPAREL and lidocaine—in providing comfort during pleuroscopy with biopsy and catheter placement in patients with pleural tumors or mesothelioma.See study design

What are the potential side effects?

Possible side effects include reactions at the injection site such as pain, swelling, redness; systemic reactions like allergies; and other side effects that are specific to each medication.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am older than 18 years.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ through study completion, an average of 1 year

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~through study completion, an average of 1 year

This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Pain

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Group A (liposomal bupivacaine)Experimental Treatment2 Interventions

Patients receive liposomal bupivacaine via injection into the intercostal nerve block.

Group II: Group B (lidocaine)Active Control2 Interventions

Patients receive lidocaine via injection into the pleuroscopy port incision sites and indwelling pleural catheter site.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Bupivacaine

FDA approved

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

M.D. Anderson Cancer CenterLead Sponsor

2,972 Previous Clinical Trials

1,787,237 Total Patients Enrolled

Horiana Grosu, MDPrincipal InvestigatorM.D. Anderson Cancer Center

Horiana GrosuPrincipal InvestigatorM.D. Anderson Cancer Center

1 Previous Clinical Trials

97 Total Patients Enrolled

Media Library

Liposomal Bupivacaine Clinical Trial Eligibility Overview. Trial Name: NCT05044468 — Phase 2

Malignant Pleural Mesothelioma Research Study Groups: Group B (lidocaine), Group A (liposomal bupivacaine)

Malignant Pleural Mesothelioma Clinical Trial 2023: Liposomal Bupivacaine Highlights & Side Effects. Trial Name: NCT05044468 — Phase 2

Liposomal Bupivacaine 2023 Treatment Timeline for Medical Study. Trial Name: NCT05044468 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there still positions available in this research trial?

"As evidenced on the clinicaltrials.gov website, this medical study is recruiting patients for enrollment and began posting back in March of 2021 with an update posted October 20th 2022."

Answered by AI

Has Liposomal Bupivacaine been explored in other scientific investigations?

"Presently, there are 215 active trial investigations into Liposomal Bupivacaine. Of these trials, 48 are in their third stage while the remaining ones are situated in Germantown, Tennessee and 1226 other locations worldwide."

Answered by AI

How many participants are enrolled in this medical research?

"Indeed, the details on clinicaltrials.gov suggest that this medical trial is presently recruiting patients. Initially posted on March 23rd 2021 and most recently edited in October 20th 2022, 80 participants are being sought from 1 site."

Answered by AI

How is Liposomal Bupivacaine typically employed in medical care?

"Liposomal Bupivacaine is frequently applied to treat small burns, as well as lupus erythematosus cell, ulcerative colitis, and transplantation."

Answered by AI

What adverse reactions could be associated with using Liposomal Bupivacaine?

"Taking into account its Phase 2 status, Liposomal Bupivacaine garnered a safety rating of 2. This is based on the availability of data indicating security but no information confirming efficacy yet."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

EXPAREL or Lidocane as Local Anesthetic in Patients Undergoing Pleuroscopy With Pleural Biopsy and Indwelling Pleural Catheter Placement

2021. "EXPAREL or Lidocane as Local Anesthetic in Patients Undergoing Pleuroscopy With Pleural Biopsy and Indwelling Pleural Catheter Placement". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05044468.

All > Lidocaine