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Non-Opioid Pain Management for Postoperative Pain

Phase 4
Waitlist Available
Led By David Chiu, MD
Research Sponsored by NYU Langone Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day1 of surgery until post operative day 14
Awards & highlights

Study Summary

This trial is testing whether using a combination of drugs to numb the skin before surgery can reduce pain and the need for painkillers afterwards.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day1 of surgery until post operative day 14
This trial's timeline: 3 weeks for screening, Varies for treatment, and day1 of surgery until post operative day 14 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Postoperative Pain control
Secondary outcome measures
Change in the amount of opioid pain medication required postoperatively

Trial Design

4Treatment groups
Experimental Treatment
Group I: Topical lidocaine and bupivacaine with thrombin and tranexamic acidExperimental Treatment4 Interventions
In this treatment group, each solution will include 5 ml of 1% lidocaine, 5 ml of 0.25% bupivacaine, 10000 units of thrombin, and 500 mg of tranexamic acid
Group II: Topical lidocaine and bupivacaine with thrombin and aminocaproic acid;Experimental Treatment5 Interventions
In this treatment group, each solution will include 5 ml of 1% lidocaine, 5 ml of 0.25% bupivacaine, 10000 units of thrombin, and 1000 mg of aminocaproic acid
Group III: Topical lidocaine and bupivacaine with thrombinExperimental Treatment3 Interventions
In this treatment group, each solution will include 5 ml of 1% lidocaine, 5 ml of 0.25% bupivacaine, 10000 units of thrombin
Group IV: Topical lidocaine and bupivacaine aloneExperimental Treatment2 Interventions
In this treatment group, each solution will include 5 ml of 1% lidocaine, 5 ml of 0.25% bupivacaine
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Tranexamic acid
2018
Completed Phase 4
~42540

Find a Location

Who is running the clinical trial?

NYU Langone HealthLead Sponsor
1,370 Previous Clinical Trials
840,799 Total Patients Enrolled
David Chiu, MDPrincipal InvestigatorNYU Langone Health
2 Previous Clinical Trials
38 Total Patients Enrolled

Media Library

Aminocaproic acid Clinical Trial Eligibility Overview. Trial Name: NCT04814433 — Phase 4
Opioid Pain Medication Research Study Groups: Topical lidocaine and bupivacaine alone, Topical lidocaine and bupivacaine with thrombin and aminocaproic acid;, Topical lidocaine and bupivacaine with thrombin and tranexamic acid, Topical lidocaine and bupivacaine with thrombin
Opioid Pain Medication Clinical Trial 2023: Aminocaproic acid Highlights & Side Effects. Trial Name: NCT04814433 — Phase 4
Aminocaproic acid 2023 Treatment Timeline for Medical Study. Trial Name: NCT04814433 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals aged 25 years and above welcome to join this clinical trial?

"This clinical trial is only open to patients aged 18-99, with 36 other trials suitable for those younger than 18 and 244 available for seniors above 65."

Answered by AI

How many participants are enlisted for this experiment?

"Affirmative. According to clinicaltrials.gov, this experiment is still recruiting volunteers; it was first publicized on March 24th 2021 and altered for the final time on February 2nd 2022. A maximum of 40 people can register across one medical centre."

Answered by AI

What medical conditions could benefit from Aminocaproic acid treatment?

"Aminocaproic acid is primarily used to treat ophthalmia and sympathetic, but can also be a beneficial treatment for laryngotracheobronchitis, unresponsive bradycardia, and permphigus."

Answered by AI

To what extent is Aminocaproic acid reliable for patient use?

"There is an abundance of evidence validating the safety and efficacy of aminocaproic acid, making it a score 3 on our team's scale. This medication has reached phase 4 clinical trials, meaning that it is already approved for medical use."

Answered by AI

What prior investigations have occurred that pertain to Aminocaproic acid?

"Presently, 292 clinical trials are underway on Aminocaproic acid, with 80 of them in their final phase. Scottsdale Arizona is the hub for most of these studies; however, there are 1453 medical centres worldwide running tests involving this drug."

Answered by AI

Do I fulfill the requirements to take part in this medical experiment?

"To qualify for enrolment, applicants must experience pain and be between 18 to 99 years old. The total amount of candidates is limited to 40 individuals."

Answered by AI

Does enrollment for this clinical experiment remain operational?

"Affirmative. According to the information on clinicaltrials.gov, this investigation is actively in search of applicants and was initially posted on March 24th 2021 with its last edit being made February 2nd 2022. The study necessitates 40 individuals from a single medical site for enrollment."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation
2021. "Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04814433.
~1 spots leftby May 2025
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