Tranexamic Acid for Postoperative Complications
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but it requires participants to be on blood-thinners. If you are taking systemic retinoids, you cannot participate.
What data supports the effectiveness of the drug tranexamic acid for reducing postoperative complications?
Is tranexamic acid generally safe for humans?
Tranexamic acid is generally safe for humans, but there have been serious safety concerns when it is mistakenly given in the wrong way, such as into the spine instead of as intended. This error can cause severe reactions like convulsions (seizures) and has a high risk of death, so hospitals are advised to store it carefully to prevent such mistakes.16789
How does the drug tranexamic acid differ from other treatments for reducing postoperative complications?
Tranexamic acid is unique because it works by preventing the breakdown of blood clots, which helps reduce blood loss during and after surgery. It is administered as an injection, often before surgical procedures like knee arthroplasty, to minimize the need for blood transfusions and manage bleeding more effectively than some other treatments.123510
What is the purpose of this trial?
This trial is testing whether injecting tranexamic acid (TXA) under the skin can reduce bleeding and pain during skin cancer surgery for patients on blood thinners. TXA helps by preventing blood clots from breaking down too quickly. The goal is to see if this method can lead to fewer complications after surgery. Tranexamic acid (TXA) has been used since the 1960s to safely control bleeding in various surgical and trauma settings.
Research Team
Riley McLean, MD
Principal Investigator
University of Massachusetts, Worcester
Eligibility Criteria
Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo Mohs micrographic surgery with or without tranexamic acid (TXA) to evaluate its efficacy in reducing peri- and post-operative complications
Follow-up
Participants are monitored for postoperative complications, including infection, bleeding, and graft failure
Treatment Details
Interventions
- Lidocaine Epinephrine
- Tranexamic acid injection
Tranexamic acid injection is already approved in European Union, United States, Canada, Japan for the following indications:
- Heavy menstrual bleeding
- Bleeding due to trauma
- Bleeding during surgery
- Hereditary angioedema
- Heavy menstrual bleeding
- Bleeding due to trauma
- Bleeding during surgery
- Heavy menstrual bleeding
- Bleeding due to trauma
- Bleeding during surgery
- Heavy menstrual bleeding
- Bleeding due to trauma
- Bleeding during surgery
Find a Clinic Near You
Who Is Running the Clinical Trial?
Riley McLean
Lead Sponsor