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Antifibrinolytic Agent

Tranexamic Acid for Postoperative Complications

Phase < 1
Waitlist Available
Led By Riley McLean, MD
Research Sponsored by Riley McLean
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 minutes post initial injection
Awards & highlights

Study Summary

This trial will evaluate whether injecting tranexamic acid (TXA) before Mohs surgery can help reduce bleeding and pain during surgery, and lead to fewer post-operative complications.

Eligible Conditions
  • Skin Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from day of surgery to 12 weeks post-operation
This trial's timeline: 3 weeks for screening, Varies for treatment, and from day of surgery to 12 weeks post-operation for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Postoperative Complications
Secondary outcome measures
Hemostasis
Injection Pain

Side effects data

From 2021 Phase 3 trial • 1226 Patients • NCT04733157
5%
Vomiting
2%
Dizziness
1%
Nausea
100%
80%
60%
40%
20%
0%
Study treatment Arm
Study Group/Group A_(Tranexamic Acid)
Control Group/Group B_(Placebo)

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Tranexamic acidExperimental Treatment2 Interventions
The TXA group will receive 2% lidocaine with 1:100,000 epinephrine mixed 50/50 with 50mg/ml TXA (with 50% dilution, this will yield 1% lidocaine with 1:200,000 epi).
Group II: ControlActive Control1 Intervention
The control group will use the routine local anesthetic of buffered 1% lidocaine with 1:200,000 epinephrine.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Tranexamic acid injection
2021
Completed Phase 4
~3060
Lidocaine Epinephrine
2019
N/A
~170

Find a Location

Who is running the clinical trial?

Riley McLeanLead Sponsor
Riley McLean, MDPrincipal InvestigatorUniversity of Massachusetts, Worcester

Media Library

Tranexamic acid injection (Antifibrinolytic Agent) Clinical Trial Eligibility Overview. Trial Name: NCT04630886 — Phase < 1
Skin Cancer Research Study Groups: Tranexamic acid, Control
Skin Cancer Clinical Trial 2023: Tranexamic acid injection Highlights & Side Effects. Trial Name: NCT04630886 — Phase < 1
Tranexamic acid injection (Antifibrinolytic Agent) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04630886 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What criteria must be met for prospective participants to qualify for this research?

"In order to be considered for inclusion in this medical trial, individuals must possess a diagnosis of skin cancer and be within the ages of 18 - 99. 200 participants are desired overall."

Answered by AI

Is this experiment currently accepting participants?

"Evident from the clinicaltrials.gov website, this trial is not presently recruiting participants. Initially posted on June 16th 2021, it was last updated April 6th 2022; however, there are 478 other studies currently accepting applicants."

Answered by AI

Are there any peer-reviewed reports that analyze the effectiveness of Tranexamic acid injection?

"Currently, 199 Tranexamic acid injection studies are in progress; 62 have reached Phase 3. While the bulk of these trials is based at one location in Duarte, California, 1319 sites throughout the world are examining this treatment's efficacy."

Answered by AI

To what medical ailments is Tranexamic acid injection commonly administered?

"Tranexamic acid injection is commonly administered for idiopathic anaphylaxis, though it has other uses such as reducing skin irritation and controlling uterine contractions or laryngotracheobronchitis."

Answered by AI

What is the total number of participants being enrolled in this investigation?

"Recruitment for this trial is no longer available. It was first posted June 16th 2021 and edited most recently on April 6th 2022. Alternatively, those interested in participating may consider the 279 clinical trials seeking participants with skin cancer or the 199 investigating tranexamic acid injections."

Answered by AI

Is the age qualification for this clinical research limited to those under 30?

"This medical study is actively enlisting individuals who are of legal age and not yet a centenarian."

Answered by AI
Recent research and studies
BmjJournal
Tranexamic Acid Use and Postoperative Outcomes in Patients Undergoing Total Hip or Knee Arthroplasty in the United States: Retrospective Analysis of Effectiveness and Safety
Poeran, J., R. Rasul, S. Suzuki, T. Danninger, M. Mazumdar, M. Opperer, F. Boettner, and S. G. Memtsoudis. 2014. “Tranexamic Acid Use and Postoperative Outcomes in Patients Undergoing Total Hip or Knee Arthroplasty in the United States: Retrospective Analysis of Effectiveness and Safety”. Bmj. BMJ. doi:10.1136/bmj.g4829.
Dermatologic SurgeryJournal
Subcutaneous Injection of Tranexamic Acid to Reduce Bleeding During Dermatologic Surgery: A Double-blind, Placebo-controlled, Randomized Clinical Trial
Zilinsky, Isaac, Tami Brutman Barazani, Denis Visentin, Kiran Ahuja, Uriel Martinowitz, and Josef Haik. 2019. “Subcutaneous Injection of Tranexamic Acid to Reduce Bleeding During Dermatologic Surgery: A Double-blind, Placebo-controlled, Randomized Clinical Trial”. Dermatologic Surgery. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/dss.0000000000001786.
clinicaltrials.govStudy
Use of Tranexamic Acid in Reduction of Post-Op Complications in Mohs Micrographic Surgery
Riley McLean 2021. "Use of Tranexamic Acid in Reduction of Post-Op Complications in Mohs Micrographic Surgery". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04630886.
~52 spots leftby Apr 2025
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