Physical Activity for Breast and Prostate Cancer Survivors

Overseen By Amy A Kirkham, PhD

Age: Any Age

Sex: Any

Trial Phase: Academic

Sponsor: University of Toronto

Must be taking: Aromatase inhibitors, Androgen deprivation

Must not be taking: Diabetes drugs

Disqualifiers: Cardiovascular, Diabetes, Renal, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

24 Participants Needed

Trial Summary

What is the purpose of this trial?

The primary aim of this study is to compare the acute glycemic effects of two novel, alternative physical activity (PA) strategies (dispersed post-meal PA, PA snacks) to a no PA condition and to exercise sessions representing the PA guidelines (standard 30-minute walking bout performed under fasting and under postprandial conditions and a standard 30-minute resistance training session) among sedentary survivors of breast and prostate cancer who are currently receiving hormone therapies. The secondary aim is to determine whether the alternative PA strategies are acceptable and feasible in the free-living setting. The exploratory aim is to determine whether these outcomes differ by cancer type. The investigators hypothesize that: 1. Dispersed PA and PA snacks will result in greater reductions in 24-hour glucose and postprandial glucose compared to the no-PA baseline and similar reductions to a standard 30-minute bouts of walking; 2. The alternative PA strategies will be more feasible and have greater acceptability by cancer survivors compared to the standard 30-minute bout of walking or resistance training; and 3. The different PA strategies will have similar effects on glycemic outcomes for both breast and prostate cancer survivors. The resistance exercise session is an exploratory trial as the effects of it on acute glycemic control are understudied.

Eligibility Criteria

This trial is for sedentary breast and prostate cancer survivors who are on hormone therapies. It's designed to test if short bursts of physical activity can help manage blood sugar better than no exercise or standard 30-minute workouts. Participants should be willing to try different exercise routines.

Inclusion Criteria

I am a postmenopausal woman with stage I-III breast cancer and am currently on aromatase inhibitors.

Body mass index equal to or greater than 25 kg/m^2

Self-report consuming three main meals daily

Exclusion Criteria

I am taking medication for diabetes or am currently losing weight.

Do not have a smartphone compatible with the applications required to collect data

Unable or unwilling to receive medical clearance by a physician after being screened for major signs or symptoms of cardiovascular diseases, diabetes, or renal disease and safety to initiate exercise

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention

Participants engage in various physical activity strategies including dispersed post-meal PA, PA snacks, standard walking, and resistance training to assess glycemic effects.

1 day per intervention

Multiple single-day interventions

Follow-up

Participants are monitored for safety and effectiveness after intervention days

4 weeks

Treatment Details

Interventions

• Alternative Physical Activity Strategies

Trial Overview The study compares the effects of 'Physical Activity Snacks', dispersed post-meal activities, and muscle strengthening exercises against a no-exercise control group and standard fasting or post-meal workouts on blood sugar levels in cancer survivors.

Participant Groups

Group I: Standard Physical Activity - Post-Meal Experimental Treatment 1 Intervention

Participants will perform 30 minutes of walking at a self-selected pace 30 minutes after the start of the first meal in the morning.

Group II: Standard Physical Activity - Fasted Experimental Treatment 1 Intervention

Participants will perform 30 minutes of walking at a self-selected pace 15 minutes prior to consumption of first meal in the morning (including cream/sugar/milk in coffee or tea).

Group III: Physical Activity Snacks Experimental Treatment 1 Intervention

Participants will perform 2 minutes of walking or marching on the spot at a self-selected pace every 30 minutes throughout the day for 7.5 waking hours.

Group IV: Muscle Strengthening Experimental Treatment 1 Intervention

Participants will perform 30 minutes of muscle strengthening exercises targeting the major muscle groups of the whole body performed by following along with a video, to start 30 minutes after the start of the first meal in the morning.

Group V: Dispersed Physical Activity Experimental Treatment 1 Intervention

Participants will perform 10 minutes of walking at a self-selected pace 30 minutes after the start of each main meal throughout the day (i.e., three bouts total).

Who Is Running the Clinical Trial?

University of Toronto

Lead Sponsor

Trials

739

Recruited

1,125,000+