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Low Radiation Dose CT Techniques for Liver Disease

N/A

Waitlist Available

Led By Corey T. Jensen, MD

Research Sponsored by M.D. Anderson Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Pathology proven diagnosis of colon or colorectal carcinoma

Liver metastases on most recent CT examination

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 day

Awards & highlights

Study Summary

This trial is comparing two different image processing techniques during a CT scan to see which one provides better image quality of the liver.

Who is the study for?

This trial is for adults aged 18 to 90 with a confirmed diagnosis of colon or colorectal cancer and liver metastases visible on their most recent CT scan. They must be scheduled for a standard care CT abdomen exam with IV contrast and able to give informed consent.Check my eligibility

What is being tested?

The study is testing two different low-dose radiation techniques during a CT scan, using artificial intelligence software called DLIR to reduce image noise. The goal is to determine which method provides clearer images for detecting issues in the liver.See study design

What are the potential side effects?

Since this trial involves imaging techniques rather than drugs, side effects are minimal but may include exposure to lower levels of radiation compared to standard CT scans.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have been diagnosed with colon or colorectal cancer.

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My latest CT scan shows cancer has spread to my liver.

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I am between 18 and 90 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 day

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 day

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 day for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Metastasis Detection Accuracy

Trial Design

3Treatment groups

Experimental Treatment

Group I: Deep Learning Image Reconstruction (DLIR)Experimental Treatment1 Intervention

DLIR is available in both single (SE) and dual/multi energy (DE) CT scanning modes. DLIR SECT and DLIR DECT reconstructions have yet to be compared.

Group II: Computed tomography Scan - 70% Dose ReductionExperimental Treatment1 Intervention

Participants undergo routine standard of care CT examination for colon carcinoma restaging, then have an additional scan of the liver at 70% dose reduction.

Group III: Computed Tomography Scan - 50% Dose ReductionExperimental Treatment1 Intervention

Participants undergo routine standard of care CT examination for colon carcinoma restaging, then have an additional scan of the liver at 50% dose reduction.

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

M.D. Anderson Cancer CenterLead Sponsor

2,966 Previous Clinical Trials

1,804,635 Total Patients Enrolled

Corey T. Jensen, MDPrincipal InvestigatorM.D. Anderson Cancer Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research open to individuals aged 40 and over?

"This clinical trial is open for people aged between 18 and 90. For those younger than 18, there are 169 trials available; whereas 4111 studies exist for those above 65 years of age."

Answered by AI

Is there an opportunity to participate in this medical experiment?

"The recruitment criteria for this trial necessitate that participants have a liver disorder and be between 18-90 years old. In total, 140 patients are sought to take part in the study."

Answered by AI

What is the enrollment capacity for this clinical trial?

"Indeed, clinicaltrials.gov corroborates that this research initiative is actively enrolling patients and has done since it was first posted on May 9th 2017. A total of 140 participants are needed to complete the study at a singular location."

Answered by AI

Are researchers still accepting participants for this experiment?

"Clinicaltrials.gov has attested to the active recruitment of participants for this research experiment, which was inaugurated on May 9th 2017 and amended most recently in August 2022."

Answered by AI

Recent research and studies

RadiologyJournal

Detection of Colorectal Hepatic Metastases Is Superior at Standard Radiation Dose CT Versus Reduced Dose CT

Jensen, Corey T., Nicolaus A. Wagner-Bartak, Lan N. Vu, Xinming Liu, Bharat Raval, David Martinez, Wei Wei, Yuan Cheng, Ehsan Samei, and Shiva Gupta. 2019. “Detection of Colorectal Hepatic Metastases Is Superior at Standard Radiation Dose CT Versus Reduced Dose CT”. Radiology. Radiological Society of North America (RSNA). doi:10.1148/radiol.2018181657.

RadiologyJournal

Reduced-dose Deep Learning Reconstruction for Abdominal CT of Liver Metastases

Jensen, Corey T., Shiva Gupta, Mohammed M. Saleh, Xinming Liu, Vincenzo K. Wong, Usama Salem, Wei Qiao, Ehsan Samei, and Nicolaus A. Wagner-Bartak. 2022. “Reduced-dose Deep Learning Reconstruction for Abdominal CT of Liver Metastases”. Radiology. Radiological Society of North America (RSNA). doi:10.1148/radiol.211838.

clinicaltrials.govStudy

Lesion Detection Assessment in the Liver: Standard vs Low Radiation Dose Using Varied Post-Processing Techniques

2017. "Lesion Detection Assessment in the Liver: Standard vs Low Radiation Dose Using Varied Post-Processing Techniques". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03151564.

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