146 Participants Needed

Low Radiation Dose CT Techniques for Liver Disease

CT
Overseen ByCorey T. Jensen, MD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: M.D. Anderson Cancer Center
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

To compare 2 different image creation/processing techniques during a standard CT scan in order to "see" problems in the liver and learn which method provides better image quality. The techniques use new artificial intelligence software to decrease image noise, which helps the radiologist to evaluate.

Who Is on the Research Team?

CT

Corey T. Jensen, MD

Principal Investigator

M.D. Anderson Cancer Center

Are You a Good Fit for This Trial?

This trial is for adults aged 18 to 90 with a confirmed diagnosis of colon or colorectal cancer and liver metastases visible on their most recent CT scan. They must be scheduled for a standard care CT abdomen exam with IV contrast and able to give informed consent.

Inclusion Criteria

I am a man or a non-pregnant woman.
I have been diagnosed with colon or colorectal cancer.
My latest CT scan shows cancer has spread to my liver.
See 1 more

Exclusion Criteria

I am unable to understand and agree to the study's procedures and risks.
I cannot have a CT scan.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo routine standard of care CT examination and additional scans at reduced radiation doses

1 day
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Computed Tomography Scan - 50% Dose Reduction
  • Computed Tomography Scan - 70% Dose Reduction
  • DLIR
Trial Overview The study is testing two different low-dose radiation techniques during a CT scan, using artificial intelligence software called DLIR to reduce image noise. The goal is to determine which method provides clearer images for detecting issues in the liver.
How Is the Trial Designed?
3Treatment groups
Experimental Treatment
Group I: Deep Learning Image Reconstruction (DLIR)Experimental Treatment1 Intervention
Group II: Computed tomography Scan - 70% Dose ReductionExperimental Treatment1 Intervention
Group III: Computed Tomography Scan - 50% Dose ReductionExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

M.D. Anderson Cancer Center

Lead Sponsor

Trials
3,107
Recruited
1,813,000+
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