Low Radiation Dose CT Techniques for Liver Disease

Overseen By Corey T. Jensen, MD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: M.D. Anderson Cancer Center

Disqualifiers: Unable to consent, Unable to undergo CT

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

146 Participants Needed

Trial Summary

What is the purpose of this trial?

To compare 2 different image creation/processing techniques during a standard CT scan in order to "see" problems in the liver and learn which method provides better image quality. The techniques use new artificial intelligence software to decrease image noise, which helps the radiologist to evaluate.

Research Team

Corey T. Jensen, MD

Principal Investigator

M.D. Anderson Cancer Center

Eligibility Criteria

This trial is for adults aged 18 to 90 with a confirmed diagnosis of colon or colorectal cancer and liver metastases visible on their most recent CT scan. They must be scheduled for a standard care CT abdomen exam with IV contrast and able to give informed consent.

Inclusion Criteria

I am a man or a non-pregnant woman.

I have been diagnosed with colon or colorectal cancer.

My latest CT scan shows cancer has spread to my liver.

Exclusion Criteria

I am unable to understand and agree to the study's procedures and risks.

I cannot have a CT scan.

Treatment Details

Interventions

• Computed Tomography Scan - 50% Dose Reduction
• Computed Tomography Scan - 70% Dose Reduction
• DLIR

Trial Overview The study is testing two different low-dose radiation techniques during a CT scan, using artificial intelligence software called DLIR to reduce image noise. The goal is to determine which method provides clearer images for detecting issues in the liver.

Participant Groups

Group I: Deep Learning Image Reconstruction (DLIR) Experimental Treatment 1 Intervention

DLIR is available in both single (SE) and dual/multi energy (DE) CT scanning modes. DLIR SECT and DLIR DECT reconstructions have yet to be compared.

Group II: Computed tomography Scan - 70% Dose Reduction Experimental Treatment 1 Intervention

Participants undergo routine standard of care CT examination for colon carcinoma restaging, then have an additional scan of the liver at 70% dose reduction.

Group III: Computed Tomography Scan - 50% Dose Reduction Experimental Treatment 1 Intervention

Participants undergo routine standard of care CT examination for colon carcinoma restaging, then have an additional scan of the liver at 50% dose reduction.

Who Is Running the Clinical Trial?

M.D. Anderson Cancer Center

Lead Sponsor

Trials

3,107

Recruited

1,813,000+