← Back to Search

N/A

No-nut diet for Cardiovascular Disease

N/A

Waitlist Available

Research Sponsored by University of California, Davis

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Overweight and obese men and postmenopausal women between 45-70 years of age, BMI range of 25.0-39.9 kg/m2 and elevated LDL-C levels (130-189 mg/dL).

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up through study completion, an average of 10 weeks

Awards & highlights

Study Summary

This trial will test if eating walnuts has any effect on blood lipids and inflammation, as well as gut bacteria.

Who is the study for?

This trial is for overweight and obese men and postmenopausal women aged between 45-70, with a BMI of 25.0-39.9 kg/m2 and higher levels of 'bad' cholesterol (LDL-C between 130-189 mg/dL).Check my eligibility

What is being tested?

The study is examining the effects of eating walnuts on heart health markers like good and bad cholesterol, inflammation in the blood, as well as gut bacteria compared to a no-nut diet.See study design

What are the potential side effects?

Potential side effects from walnut consumption may include digestive discomfort or allergic reactions for those with nut allergies.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ through study completion, an average of 10 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~through study completion, an average of 10 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 10 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Lipids

Assessing the influence of walnut consumption on blood pressure.

Assessing the influence of walnut consumption on circulating inflammatory markers: PAI-1, VCAM-1 and ICAM-1.

Secondary outcome measures

Assessing the influence of walnut consumption on fecal moisture.

Assessing the influence of walnut consumption on fecal pH.

Assessing the influence of walnut consumption on plasma and urine levels of walnut-derived metabolites - urolithins.

+2 more

Other outcome measures

Anthropometric measurements

Food record analysis

Measure of changes in weight

Trial Design

2Treatment groups

Active Control

Group I: No-nut dietActive Control1 Intervention

Participants will follow a no-nut diet for 3 weeks.

Group II: Walnut dietActive Control1 Intervention

Participants will consume 56 g of walnuts each day at home for 3 weeks.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of California, DavisLead Sponsor

910 Previous Clinical Trials

4,706,961 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

To be considered for this experimentation, what qualifications do I need to meet?

"This trial is recruiting 30 adults aged 45-70 with ellagitannins. In addition, participants must identify as either overweight or obese men or postmenopausal women and have a BMI between 25.0 to 39.9 kg/m2 plus elevated LDL-C levels (130-189 mg/dL)."

Answered by AI

What is the primary purpose of this clinical experiment?

"This clinical trial, which is expected to conclude in an average of 10 weeks, aims to assess the influence of walnut consumption on circulating inflammatory markers such as PAI-1, VCAM-1 and ICAM-1. Secondary goals include measuring fecal levels of lipocalin-2 and calprotectin with ELISA kits; assessing the effect on fecal moisture by weighing wt and vacuum dried feces; and examining plasma & urine urolithins through metabolomics analysis at each visit."

Answered by AI

Does this scientific trial include participants aged 55 and above?

"To be eligible for this investigation, individuals must possess ages between 45 and 70. For those who are younger than 18 years old, there exist 56 studies that they may join; similarly 636 trials accommodate participants above the age of 65."

Answered by AI

How many participants is this research endeavor enrolling?

"Affirmative. The information hosted on clinicaltrials.gov is clear that this medical trial, which was initially posted on April 19th 2022, is currently enrolling patients. A total of 30 patients will be needed to fill a single medical centre's quota for the study."

Answered by AI

Are there any open slots in this experiment for new participants?

"As evidenced by clinicaltrials.gov, this medical research is currently seeking enrollees; its initial listing was on April 19th 2022 with the latest update taking place on May 9th 2022."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Response of Cardiometabolic Biomarkers and Gut Microbiota to Walnut Consumption

Francene Steinberg 2022. "Response of Cardiometabolic Biomarkers and Gut Microbiota to Walnut Consumption". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05321277.

All > Diet