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Alpha-2 Adrenergic Agonist

High Volume-Low Concentration with clonidine for Circumcision

Phase < 1
Waitlist Available
Led By Christopher Heine, MD
Research Sponsored by Medical University of South Carolina
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 hours
Awards & highlights

Study Summary

This trial is testing whether adding clonidine to a local anesthetic for a caudal block (injection near the tailbone) will improve pain relief and decrease agitation after surgery in children.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Administration of Rescue Pain Medications
Presence of Pain
Time to first Administration of Acetaminophen
Secondary outcome measures
Average Time to Discharge
Hemodynamic Changes
Incidence of Emergence Delirium
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: High Volume-Low Concentration with clonidineExperimental Treatment1 Intervention
The study intervention will be High Volume-Low Concentration with clonidine (1.5cc/kg of 0.15% ropivacaine, with 1mcg/cc of clonidine and 5mcg/cc epinephrine).
Group II: High Volume-Low Concentration without ClonidineActive Control1 Intervention
The control for this study will be a High Volume-Low Concentration (1.5cc/kg of 0.15% ropivacaine and 5mcg/cc epinephrine).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
High Volume-Low Concentration with clonidine
2020
Completed Early Phase 1
~130

Find a Location

Who is running the clinical trial?

Medical University of South CarolinaLead Sponsor
933 Previous Clinical Trials
7,394,507 Total Patients Enrolled
Christopher Heine, MDPrincipal Investigator - Medical University of South Carolina
Medical University of South Carolina

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
High Volume Caudal Study
Christopher Heine, MD 2020. "High Volume Caudal Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04263064.
~25 spots leftby Apr 2025
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