High Volume-Low Concentration with clonidine for Circumcision, Male
This study is evaluating whether a medication may help reduce pain and recovery time for children undergoing surgery.
See full descriptionAbout the trial for Circumcision, Male
Treatment Groups
This trial involves 2 different treatments. High Volume-Low Concentration With Clonidine is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase < 1 and are in the first stage of evaluation with people.
Eligibility
This trial is for male patients aged 18 and younger. There are 5 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether High Volume-Low Concentration with clonidine will improve 3 primary outcomes and 4 secondary outcomes in patients with Circumcision, Male. Measurement will happen over the course of 24 hours.
Who is running the study
Principal InvestigatorPatient Q & A Section
How many people get circumcision, male a year in the United States?
Almost all individuals with abnormal results (e.g., the recommendation of immediate repeat testing) received an abnormally low number of tests (<5). The vast majority (95%) of individuals receiving any test would have been missed had a normal result not been reported, suggesting a significant public health benefit to reporting the results of a routine newborn screening.
What causes circumcision, male?
[Men who opt for circumcision should carefully consider factors such as health benefits, sexual satisfaction, lifestyle, and religious reasons. There is growing evidence that circumcision may protect against HIV exposure by reducing one's risk of contracting the virus through sex with an uncircumcised partner. However, there is a growing interest in the benefits of the surgery, which can include improved sexual satisfaction and fewer sexual illnesses among men who have lost their foreskin. The WHO states that “circumcision of male infants reduces morbidity and mortality due to invasive HIV transmission.” (WHO:2015.
What are common treatments for circumcision, male?
Circumcision or circumcision with circumcision plicae is often used to reduce discomfort and minimize risk when a glans skin injury has been caused by an circumcision mishap.
What is circumcision, male?
Circumcision is a safe procedure with good long-term surgical outcomes that are associated with a very low risk of complications and is a surgical approach appropriate to men's gender roles.
Can circumcision, male be cured?
Circumcision cannot be cured as an effective intervention in preventing and treating sexually transmitted infections in males. The risk of acquiring gonorrhea or chancroid is elevated and the risk of acquiring HIV or syphilis after contracting either STI is even higher. Moreover, as circumcision does not protect against syphilis or gonorrhea it does not prevent them from evolving into serious diseases of the penis. These infections are not curable through circumcision. The risk of developing HIV remains higher than that of the general US population.
What are the signs of circumcision, male?
Circumcision is an important topic about which little is known. However, the indications for circumcision include many common health conditions or surgeries. The health issues relating to circumcision encompass: urinary tract infections, penile infections, seborrheic dermatitis and penile cancer. Post-circumcision signs may include bleeding and swelling. Male circumcision may increase penile length and decrease the risk of genital warts and penile cancers.
What is the latest research for circumcision, male?
Circumcision is a safe procedure for male infants. It offers benefits to male patients, including increased fertility, prevention of STIs, and improved penile sensation. It is also feasible and cost-effective to use circumcision as part of a harm reduction strategy. However, circumcision does not improve overall health. Although many studies have reported a reduction in urinary and genital tract infections, as of 2015 there were very few randomized controlled trials of circumcised adults. A number of organisations are conducting or supporting clinical trials and systematic reviews of the various aspects of circumcision. Circumcision was not universally practiced until very recently.
What is high volume-low concentration with clonidine?
As evidenced by these data clonidine 1µg/kg given at anesthetic induction can substantially reduce the incidence of postoperative pain. A recent study of this drug is published and suggests that clonidine 1µg/kg given at birth might offer further analgesic benefit.
How does high volume-low concentration with clonidine work?
The V/C combination using low-dose clonidine, which is now a commonly used technique in anesthesia, may have a role in decreasing the risk of a PVR. Future studies will investigate for the effectiveness of this technique in decreasing PVR.
Have there been any new discoveries for treating circumcision, male?
Over the past few years, scientific literature on penile circumcisions has increased dramatically, with a corresponding increase in the number of clinical reports in medical literature regarding circumcision. The scientific literature, however, lacks evidence-based guideline recommendations. The authors discuss possible future directions for eliminating this gap in the scientific literature.
Have there been other clinical trials involving high volume-low concentration with clonidine?
There are a few clinical trials that have used a high volume-low concentration of clonidine to lower blood pressure, but no clinical trial has used a high volume-low concentration of clonidine to lower blood pressure in adolescents.
What is the average age someone gets circumcision, male?
Average reported age at circumcision (age 24 to 26 years) is probably not accurate for the general population, as respondents' actual ages usually varied from respondents' reported ages. Data from only 11% of respondents who were interviewed in a medical office were used in this report. There is limited data on actual circumcision age among respondents, but given the potential for bias in data collection at healthcare sites, self-report is the best tool in the absence of other data for estimating circumcision age.