Ketamine + Propofol for Cardiac Surgery
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to investigate the affects of ketamine use for anesthesia at the beginning of heart surgery on kidneys compared to the use of propofol.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are using immunosuppressive medications like steroids or anti-rejection drugs.
How is the drug combination of ketamine and propofol unique for cardiac surgery?
The combination of ketamine and propofol, known as ketofol, is unique because it combines the pain-reducing effects of ketamine with the sedative properties of propofol, potentially minimizing pain during anesthesia induction while maintaining stable heart function, which is crucial for cardiac surgery.12345
Who Is on the Research Team?
Erica D Wittwer, MD, PhD
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
This trial is for individuals at the Mayo Clinic in Rochester, Minnesota who are scheduled for complex heart surgery involving multiple valves or a redo-sternotomy. Candidates must not have severe kidney dysfunction, be on immunosuppressive drugs, have active infections requiring intense treatment, need ventricular assist device procedures, or suffer from severe liver disease.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Anesthesia Induction
Participants receive either Ketamine or Propofol for anesthesia induction during cardiac surgery
Postoperative Monitoring
Participants are monitored for acute kidney injury and vasopressor use following cardiac surgery
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Ketamine
- Propofol
Ketamine is already approved in United States, European Union, Canada for the following indications:
- Anesthesia
- Treatment-resistant depression
- Anesthesia
- Treatment-resistant depression
- Treatment-resistant depression
- Treatment-resistant depression
- Treatment-resistant depression
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor