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Cryoneurolysis

Cryoneurolysis for Knee Pain

N/A

Recruiting

Research Sponsored by Unity Health Toronto

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 12 months postoperative

Awards & highlights

Study Summary

This trial is testing a handheld device to freeze nerves and relieve pain before knee replacement surgery in order to reduce post-surgery pain and opioid use.

Eligible Conditions

Osteoarthritis
Chronic Knee Pain

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 12 months postoperative

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~12 months postoperative

This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months postoperative for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Patient recruitment rate

Secondary outcome measures

EQ-5D-5L

Numeric Rating Scale of Pain

Opioid consumption

+2 more

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: IoveraExperimental Treatment1 Intervention

Cryoneurolysis + standard of care: Usual intervention plus pre-operation Iovera treatment. Patients will receive local anaesthesia unilaterally to the affected knee prior to the treatment and then the anesthesiologist will administer the freezing cold therapy (Iovera device) to the affected knee.

Group II: PlaceboPlacebo Group1 Intervention

Placebo: Usual intervention plus pre-operation placebo. The placebo group will receive short-acting local anaesthesia injection unilaterally to the affected knee.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Unity Health TorontoLead Sponsor

537 Previous Clinical Trials

447,519 Total Patients Enrolled

Media Library

Iovera - Cryoneurolysis (Cryoneurolysis) Clinical Trial Eligibility Overview. Trial Name: NCT05286996 — N/A

Osteoarthritis Research Study Groups: Iovera, Placebo

Osteoarthritis Clinical Trial 2023: Iovera - Cryoneurolysis Highlights & Side Effects. Trial Name: NCT05286996 — N/A

Iovera - Cryoneurolysis (Cryoneurolysis) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05286996 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research protocol open to geriatric patients?

"This trial has been designed to include patients aged 18 - 80. There are 31 medical studies exclusively for minors and a further 605 clinical trials specifically tailored towards elderly individuals."

Answered by AI

Are there any vacancies for participants in this trial?

"Clinicaltrials.gov proclaims that this medical trial is still actively recruiting, with an initial post date of December 1st 2022 and a most recent edit done on May 10th 2023."

Answered by AI

What is the cap for enrollment in this experiment?

"Affirmative. According to clinicaltrials.gov, the trial first posted on December 1st 2022 is currently recruiting patients and was recently updated on May 10th 2023. The research requires a total of 20 volunteers at one location."

Answered by AI

Is it permissible for me to join this research endeavor?

"This clinical trial is in need of 20 participants with osteoarthritis between the ages 18 to 80. The following criteria must be fulfilled: Male and female candidates, confirmed radiographic correlation for severe OA diagnosis requiring a knee replacement surgery, no prior injection within half a year before joining the study, able to understand English & provide informed consent."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Cryoneurolysis for TKA - a Pilot Study

2022. "Cryoneurolysis for TKA - a Pilot Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05286996.