Thromboelastography for Burns

Overseen By Hilary Y Liu, BS

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Francesco Egro

Disqualifiers: Venous thromboembolism, Hyper/hypocoagulopathy

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 5

Duration: 4 weeks

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores a blood test called thromboelastography (TEG) to determine how burn injuries affect blood clotting. Researchers aim to understand if the size of the burn influences blood clotting and whether these changes can predict recovery or complications. The goal is to enhance how doctors diagnose and treat clotting issues in burn patients. This trial may suit those admitted to the hospital with a burn injury who wish to help advance treatment methods. As an unphased trial, this study offers a unique opportunity to contribute to foundational research that could significantly enhance future burn treatment strategies.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team or your doctor.

What prior data suggests that thromboelastography is safe for evaluating clotting in burn patients?

Research has shown that thromboelastography (TEG), a special blood test, is safe for patients. Studies have used TEG to examine blood clotting in patients with severe burns and found no harmful effects from TEG itself. Instead, these studies highlighted how TEG helps doctors understand changes in blood clotting, which is important for treating burns.

TEG is not a treatment but a way to measure blood clotting. As a non-invasive method, it is generally considered safe. This makes it a helpful tool for monitoring how burns affect blood clotting over time. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Thromboelastography is unique because it provides a detailed picture of how blood clots form and break down in the body, which is especially important for burn patients who often face complex blood clotting issues. Unlike traditional treatments that might focus on replacing lost fluids or managing infections, thromboelastography offers real-time insights into the clotting process. Researchers are excited because this method could lead to more personalized and effective treatments by allowing doctors to tailor interventions based on each patient's specific clotting profile. This could potentially improve outcomes and reduce complications for those suffering from severe burns.

What evidence suggests that thromboelastography is effective for evaluating clotting abnormalities in burn patients?

Research has shown that thromboelastography (TEG) effectively checks blood clotting in patients with burns. Studies have found that TEG can identify clotting problems early, which is crucial because burns can cause complex changes in blood clotting. Early detection is key to preventing complications. In burn patients, unusual clotting patterns identified by TEG have been linked to worse outcomes. Understanding these patterns can lead to better treatment and improved recovery. Overall, TEG offers a promising method to monitor and manage clotting in burn patients. ^{2 4 6 7 8}

Who Is on the Research Team?

Francesco M Egro, MD, MSc, MRCS

Principal Investigator

Department of Plastic Surgery, University of Pittsburgh Medical Center

Are You a Good Fit for This Trial?

This trial is for burn patients. It's looking at how their injuries affect blood clotting. To join, people must have a certain percentage of their body burned but the exact criteria aren't specified here.

Inclusion Criteria

Provided consent to participate in the study

I was recently admitted for a burn injury.

Exclusion Criteria

I have a history of blood clots or abnormal blood clotting.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants undergo thromboelastography (TEG) testing to evaluate clotting abnormalities over a 4-week period

4 weeks

5 visits (in-person) on Day 1, Day 7, Day 14, Day 21, and Day 28

Follow-up

Participants are monitored for safety and effectiveness after treatment, including tracking hospital length of stay and complications

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Thromboelastography

Trial Overview The study uses thromboelastography (TEG), a test that measures blood clots, to see how burn injuries change clotting over time and if this can predict recovery or complications.

How Is the Trial Designed?

Group I: Burn Thromboelastography Group Experimental Treatment 1 Intervention

Overall study population (all participants are in the same group). See eligibility for further details.

Who Is Running the Clinical Trial?

Francesco Egro

Lead Sponsor

Trials

2

Recruited

320+

Citations

1. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC5965330/

Measuring coagulation in burns: an evidence-based ... Outcome data. Outcomes of interest were: the potential role of anticoagulant factors; coagulation markers in burn injury and any association ...

2. sciencedirect.com sciencedirect.com/science/article/abs/pii/S002013832200729X

Clinical significance of R-TEG in severe burn patients with ... The aim of this study was to retrospectively analyze Thrombelastography (TEG) data of severe burn patients to provide a clinical basis for timely diagnosis and ...

3. withpower.com withpower.com/trial/phase-burns-5-2025-718e3

Thromboelastography for Burns · Info for Participants This pilot study examines the use of thromboelastography (TEG), a specialized blood test, to evaluate clotting abnormalities in burn patients.

4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC7439938/

Burn-Induced Coagulopathies: a Comprehensive Review - PMC Dysfunctional platelets at any point after burn injury correlate with poor outcomes. TAT and FVII activity remain elevated in the week following burn injury ...

5. link.springer.com link.springer.com/article/10.1007/s11239-025-03173-4

Use of viscoelastic testing in the transfusion management ... Severe burns cause complex hemostatic alterations that complicate transfusion management. Conventional coagulation tests (CCTs) have ...

6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC10955108/

Thromboelastometric Analysis of the Correlation Between ... Background In this study, we aimed to analyze the association between the burn index (BI) and burn-induced coagulopathy.

7. sma.org sma.org/abstracts/oagulopathy-of-burns/

Assessment of the Coagulopathy of Burns with ... In a limited sized study, thromboelastometry at a median of 3 days was useful in projecting future transfusion requirements.

8. journals.sagepub.com journals.sagepub.com/doi/10.1177/2059513117728201

Measuring coagulation in burns: an evidence-based ... Current evidence suggests that burn injury involves an uncontrolled increase in the coagulation system, in proportion to the TBSA burned.