Antibiotic stewardship messaging for Pneumonia

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Pneumonia
Antibiotic stewardship messaging - Behavioral
Eligibility
18+
All Sexes
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Study Summary

This trial is testing whether an electronic alert or pharmacist outreach can help decrease unnecessary antibiotics prescribed to hospitalized patients for possible pneumonia.

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 8 Secondary · Reporting Duration: Duration of hospitalization, up to 90 days

14 days post-randomization
Acute kidney injury (maximum creatinine in the 14-days post-randomization)
30-days post-randomization
Antibiotic-free days in the 30-days post-randomization
C. difficile infections in the 30-days post-randomization
Hospital-free days in the 30-days post-randomization
Readmissions within 30-days of randomization
Day 90
Days from randomization to discharge
Hospital length of stay
Day 90
In-hospital mortality
Day 30
Duration of antibiotics prescribed for pneumonia

Trial Safety

Trial Design

3 Treatment Groups

Usual care
1 of 3
Electronic alert
1 of 3
Pharmacist
1 of 3

Active Control

Experimental Treatment

2000 Total Participants · 3 Treatment Groups

Primary Treatment: Antibiotic stewardship messaging · No Placebo Group · N/A

Electronic alert
Behavioral
Experimental Group · 1 Intervention: Antibiotic stewardship messaging · Intervention Types: Behavioral
Pharmacist
Behavioral
Experimental Group · 1 Intervention: Antibiotic stewardship messaging · Intervention Types: Behavioral
Usual careNoIntervention Group · 1 Intervention: Usual care · Intervention Types:

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: duration of hospitalization, up to 90 days

Who is running the clinical trial?

Centers for Disease Control and PreventionFED
820 Previous Clinical Trials
21,541,960 Total Patients Enrolled
12 Trials studying Pneumonia
13,068 Patients Enrolled for Pneumonia
Brigham and Women's HospitalLead Sponsor
1,472 Previous Clinical Trials
9,733,265 Total Patients Enrolled
6 Trials studying Pneumonia
26,691 Patients Enrolled for Pneumonia
Michael Klompas, MDPrincipal InvestigatorBrigham and Women's Hospital

Eligibility Criteria

Age 18+ · All Participants · 1 Total Inclusion Criteria

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About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 22nd, 2021

Last Reviewed: November 11th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.