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Antibiotic

Antibiotic Duration for Severe Lung Infections (BALANCE Trial)

N/A
Waitlist Available
Led By Nick Daneman, MD
Research Sponsored by Sunnybrook Health Sciences Centre
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up expected average of 4 weeks assessed upto one year
Awards & highlights

BALANCE Trial Summary

This trial suggests that, for patients with ventilator-associated pneumonia, 8 days of treatment is as effective as 15 days.

Who is the study for?
This trial is for critically ill patients in the ICU or other hospital wards with a bacterial blood infection confirmed by a positive blood culture. It's not for those with certain heart valve conditions, specific types of bacteria or fungi in their blood, previous enrollment, severe immune compromise, infections requiring long treatments, or rare pathogens.Check my eligibility
What is being tested?
The study tests if 7 days of antibiotics are as effective as the standard 14 days for treating bloodstream infections in critically ill patients. The goal is to see if shorter treatment can work and help combat antibiotic resistance without compromising patient health.See study design
What are the potential side effects?
Potential side effects from antibiotic treatment may include allergic reactions, gastrointestinal issues like nausea and diarrhea, yeast infections due to flora imbalance, kidney and liver function changes, and possibly increased resistance to antibiotics.

BALANCE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~expected average of 4 weeks assessed upto one year
This trial's timeline: 3 weeks for screening, Varies for treatment, and expected average of 4 weeks assessed upto one year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
90 day survival
Secondary outcome measures
Antibiotic allergy and adverse events
Antibiotic free days
Hospital length of stay
+7 more

BALANCE Trial Design

2Treatment groups
Active Control
Group I: Short duration (7 days)Active Control1 Intervention
Patients in 7 day arm will receive adequate antibiotics until the end of day 7 only
Group II: Long duration (14 days)Active Control1 Intervention
Patients in 14 day arm will receive adequate antibiotics until the end of day 14 only

Find a Location

Who is running the clinical trial?

Sunnybrook Health Sciences CentreLead Sponsor
651 Previous Clinical Trials
1,539,067 Total Patients Enrolled
Nick Daneman, MDPrincipal InvestigatorSunnybrook Health Sciences Centre
5 Previous Clinical Trials
1,098 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the participant threshold for this clinical examination?

"This clinical trial requires 3622 people, who meet the strict selection criteria, to participate from numerous locations such as Royal Columbian Hospital in Vancouver and NYU School of Medicine in New york."

Answered by AI

Where can this research be conducted?

"This medical study is taking place in numerous locations, such as Royal Columbian Hospital (Vancouver, British Columbia), NYU School of Medicine (New york, New York) and Brantford General Hospital (Toronto, Ontario), among 36 other sites."

Answered by AI

Are there still openings for enrolment in this trial?

"According to the clinicaltrials.gov page, this trial is presently looking for candidates. The initial posting occurred on February 24th 2017 and was recently modified on December 1st 2022."

Answered by AI

Who else is applying?

What state do they live in?
Ohio
What site did they apply to?
Cleveland Clinic
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
1

Why did patients apply to this trial?

I've been having this treated off and on for over a year. It will start to heal then out of the blue I spreads and comes back to a different area nearby. I can't take the pain anymore and I can only walk for 30 seconds. I can't even stand up that long please help.
PatientReceived 2+ prior treatments

What questions have other patients asked about this trial?

How soon can I be seen and when does this trial start?
PatientReceived 1 prior treatment
~448 spots leftby Mar 2025