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Clinical Trials in Los Angeles, CA
View medical research that is recruiting in Los Angeles, California. Filter by phase, distance, and inclusion criteria to find cutting edge treatments & access premium care.
Condition
Location
Distance
10 Miles
Any
Age
Search
Clinical Trials
Clinical Trials in Los Angeles, CA
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
SLS-005
for Spinocerebellar Ataxia Type 3
Los Angeles, CA
18+
All Sexes
Phase 2 & 3
Recruiting
Los Angeles, CA
18+
All Sexes
Phase 2b/3 double blind, randomized, placebo-controlled trial to assess safety and efficacy of SLS-005 (trehalose injection, 90.5 mg/mL for intravenous infusion) for the treatment of adults with spinocerebellar ataxia).
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Focused Ultrasound
for Familial Tremor
Los Angeles, CA
18+
All Sexes
Phase < 1
Recruiting
Los Angeles, CA
18+
All Sexes
The purpose of this Phase I open label study is to evaluate longer term tolerability and potential effectiveness of transcranial ultrasound in people with tremor as a results of Parkinson's Disease or Essential Tremor.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Community Health Worker Led Curriculum
for Community Health Workers
Los Angeles, CA
Any Age
All Sexes
Recruiting
Los Angeles, CA
Any Age
All Sexes
The objective of this study is to compare the results of a COVID-19 specific curriculum led by LACDHS Community Health Workers (CHWs) from these same communities of safety-net patients to effectively increase COVID-19 testing and vaccination for individual patients, and to facilitate needed healthcare in a timely manner for the safety net health system, and to develop a sustained public health presence in these communities to build trust and preparedness for critical COVID-19 related future needs.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
SPI-62 Dose1
for Cushing Syndrome
Ann Arbor, MI
18+
All Sexes
Phase 2
Recruiting
Ann Arbor, MI
18+
All Sexes
This will be a randomized, double-blind study to evaluate the efficacy, safety, and pharmacological effect of SPI-62 in subjects with hypercortisolism related to a benign adrenal tumor.
Phase-Based Progress Estimates
3
Effectiveness
3
Safety
Cabotegravir OLI
for HIV Infections
Los Angeles, CA
18+
Male
Phase 4
Recruiting
Los Angeles, CA
18+
Male
This is a two-arm study evaluating the impact of two implementation strategy conditions, dynamic implementation and routine implementation on the feasibility of delivering of Cabotegravir PrEP in low and high-volume PrEP sites in the United States for men who have sex with men (MSM) and Transgender men ≥ 18 years of age. There are two types of participants in the study. Patient Study Participants (PSPs) will refer to individuals who are enrolled in the study and who will receive commercially available Cabotegravir PrEP via prescription from the PrEP provider at the corresponding site. Staff Study Participants (SSPs) will refer to site staff who are involved in administrative and clinical aspects of offering and administering PrEP to PSPs and will participate in the staff study assessments.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Nirogacestat
for Ovarian Cancer
Covington, LA
18+
Female
Phase 2
Recruiting
1 Prior Treatment
Covington, LA
18+
Female
This phase 2 clinical trial will study the effectiveness of nirogacestat in ovarian granulosa cell tumors (OvGCTs). Nirogacestat is a gamma secretase inhibitor (GSI) which is hypothesized to decrease the growth and activity of ovarian granulosa tumors.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Obicetrapib
for Hypercholesterolemia
Los Angeles, CA
18+
All Sexes
Phase 2
Waitlist Available
Los Angeles, CA
18+
All Sexes
This study will be a placebo-controlled, double-blind, randomized, phase 2 study to evaluate the efficacy, safety, and tolerability of obicetrapib 10 mg, both in combination with ezetimibe 10 mg and as monotherapy, as an adjunct to high-intensity statin therapy.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Nirmatrelvir
for COVID-19
Washington, United States
< 18
All Sexes
Phase 2 & 3
Recruiting
Washington, United States
< 18
All Sexes
The purpose of this clinical trial is to learn about the safety, pharmacokinetics (pharmacokinetics helps us understand how the drug is changed and eliminated from your body after you take it), and efficacy (how well a study treatment works in the study) of the study medicine (called nirmatrelvir/ritonavir) for potential treatment of coronavirus disease 2019 (COVID-19). The study medicine will be given to patients under 18 years of age with COVID-19 that are not hospitalized but are at risk for severe disease.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Pembrolizumab
for Cancer of Oropharnyx
Los Angeles, CA
18+
All Sexes
Phase 2
Recruiting
Class II
Los Angeles, CA
18+
All Sexes
This phase II trial compares the effect of adding ipatasertib to pembrolizumab (standard immunotherapy) vs. pembrolizumab alone in treating patients with squamous cell cancer of the head and neck that has come back (recurrent) or has spread to other places in the body (metastatic). Ipatasertib is in a class of medications called protein kinase B (AKT) inhibitors. It may stop the growth of tumor cells and may kill them. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving ipatasertib in combination with pembrolizumab may be more effective than pembrolizumab alone in improving some outcomes in patients with recurrent/metastatic squamous cell cancer of the head and neck.
Phase-Based Progress Estimates
2
Effectiveness
3
Safety
Photon Beam Radiation Therapy
for Glioblastoma
Sacramento, CA
18+
All Sexes
Phase 3
Recruiting
Newly Diagnosed
Sacramento, CA
18+
All Sexes
This phase III trial compares the effect of adding lomustine to temozolomide and radiation therapy versus temozolomide and radiation therapy alone in shrinking or stabilizing newly diagnosed MGMT methylated glioblastoma. Chemotherapy drugs, such as lomustine and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy photons to kill tumor cells and shrink tumors. Adding lomustine to usual treatment of temozolomide and radiation therapy may help shrink and stabilize glioblastoma.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
20 Mg CBD + 20 Mg THC Cannabis
for Drug Abuse
Los Angeles, CA
18 - 65
All Sexes
Phase 1
Recruiting
Los Angeles, CA
18 - 65
All Sexes
This study is evaluating whether there are differences in the pharmacokinetics and pharmacodynamics of inhaled cannabis with varying amounts of THC, and CBD.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Nanoplexed Poly I:C BO-112
for Carcinoma
Los Angeles, CA
18+
All Sexes
Phase < 1
Recruiting
Locally Advanced
Los Angeles, CA
18+
All Sexes
This study is evaluating whether BO-112 and pembrolizumab may be effective in treating patients with liver cancer.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Prasinezumab
for Parkinsons Disease
Los Angeles, CA
18+
All Sexes
Phase 2
Recruiting
Stage I
Los Angeles, CA
18+
All Sexes
This study is evaluating whether a drug may help people with Parkinson's disease.
Phase-Based Progress Estimates
2
Effectiveness
3
Safety
Amniotic Suspension Allograft
for Arthrosis
Los Angeles, CA
18+
All Sexes
Phase 3
Recruiting
Grade II
Los Angeles, CA
18+
All Sexes
This study is evaluating whether a common pain reliever may help treat knee pain associated with osteoarthritis.
Phase-Based Progress Estimates
2
Effectiveness
3
Safety
Tirzepatide
for Type 2 Diabetes Mellitus
Greenville, NC
18+
All Sexes
Phase 3
Waitlist Available
Greenville, NC
18+
All Sexes
This study is evaluating whether a new drug may help improve blood sugar control in individuals with type 2 diabetes.
Phase-Based Progress Estimates
2
Effectiveness
3
Safety
Elafibranor 80mg
for Liver Cirrhosis, Biliary
Los Angeles, CA
18+
All Sexes
Phase 3
Recruiting
Los Angeles, CA
18+
All Sexes
This study is evaluating whether a drug may help patients with primary biliary cholangitis.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Remdesivir
for COVID-19
Los Angeles, CA
18+
All Sexes
Phase 2
Recruiting
Los Angeles, CA
18+
All Sexes
This study is evaluating whether a new treatment may help critically ill patients.
Phase-Based Progress Estimates
2
Effectiveness
3
Safety
Alpelisib
for Advanced HER2+Breast Cancer
Los Angeles, CA
18+
All Sexes
Phase 3
Recruiting
Locally Advanced
Los Angeles, CA
18+
All Sexes
This study is evaluating whether a drug may help treat breast cancer.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
ASTX295
for Tumors, Solid
Los Angeles, CA
18+
All Sexes
Phase 1 & 2
Recruiting
Locally Advanced
Los Angeles, CA
18+
All Sexes
This study is evaluating whether a drug may help treat tumors with a specific genetic mutation.
Phase-Based Progress Estimates
2
Effectiveness
3
Safety
Pembrolizumab
for Pathologic Stage I Merkel Cell Carcinoma AJCC v8
Fort Smith, AR
18+
All Sexes
Phase 3
Recruiting
Metastatic
Fort Smith, AR
18+
All Sexes
This phase III trial studies how well pembrolizumab works compared to standard of care observation in treating patients with stage I-III Merkel cell cancer that has been completely removed by surgery (resected). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Cediranib Maleate
for Endometrioid Adenocarcinoma
Los Angeles, CA
18+
Female
Phase 2
Recruiting
Grade I
Los Angeles, CA
18+
Female
This study is evaluating whether a combination of drugs may be more effective than a single drug in treating endometrial cancer.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Directional Deep Brain Stimulation
for Depression
Los Angeles, CA
18+
All Sexes
Recruiting
1 Prior Treatment
Los Angeles, CA
18+
All Sexes
This study is evaluating whether deep brain stimulation (DBS) can be used to treat depression.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
SL-401
for Leukemia, Myelomonocytic, Acute
Los Angeles, CA
18+
All Sexes
Phase 2
Recruiting
Stage II
Los Angeles, CA
18+
All Sexes
This study is evaluating whether a drug may help treat chronic myelomonocytic leukemia or myelofibrosis.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Short-term Fasting
for Fasting in Malignant Solid Tumors
Los Angeles, CA
18+
All Sexes
Waitlist Available
Locally Advanced
Los Angeles, CA
18+
All Sexes
This study is evaluating whether fasting before chemotherapy may reduce the side effects caused by chemotherapy.
Phase-Based Progress Estimates
2
Effectiveness
3
Safety
Paltusotine
for Acromegaly
Pittsburgh, PA
18+
All Sexes
Phase 3
Recruiting
Pittsburgh, PA
18+
All Sexes
A randomized, placebo-controlled study designed to evaluate the safety and efficacy of paltusotine (formerly CRN00808; an oral selective nonpeptide somatostatin receptor type 2 biased agonist) in subjects with non-pharmacologically treated acromegaly.
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Other Trials to Consider
Medtronic Summit System, Olympus
for Aura
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Phase 1
Recruiting
Rochester, MN
18+
All Sexes
AZD0466
for Lymphoma, Diffuse
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Phase 1 & 2
Recruiting
Locally Advanced
Baltimore, MD
18+
All Sexes
OnabotulinumtoxinA X
for Glabellar Lines
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Phase 2
Waitlist Available
Glendale, AZ
18+
All Sexes
Nemvaleukin And Pembrolizumab Combination
for Ovary Cancer
Phase-Based Progress Estimates
2
Effectiveness
3
Safety
Phase 3
Recruiting
Ventura, CA
18+
Female
AGN-151586
for Glabellar Lines
Phase-Based Progress Estimates
2
Effectiveness
3
Safety
Phase 3
Recruiting
Birmingham, AL
18+
All Sexes
FEIBA
for Cardiac Diseases
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Phase 2
Recruiting
Rochester, MN
< 18
All Sexes
Oral Anti-acid Treatment
for Fistula
Phase-Based Progress Estimates
3
Effectiveness
3
Safety
Phase 4
Recruiting
Vancouver, Canada
< 65
All Sexes
IDP-118 Lotion
for Psoriasis
Phase-Based Progress Estimates
3
Effectiveness
3
Safety
Phase 4
Recruiting
Murray, UT
< 18
All Sexes
Kardia Mobile 6L Device
for Atrial Fibrillation
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Recruiting
Chicago, IL
18+
All Sexes
Team-Based Connected Health (TCH)
for Eczema
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Recruiting
Los Angeles, CA
Any Age
All Sexes
GPS Clinical Intervention
for Disease
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Recruiting
Montréal, Canada
65+
All Sexes
Baby Sleep
for Parenting
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Recruiting
Buffalo, NY
18+
All Sexes
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