Clinical Trials in Los Angeles, CA

View medical research that is recruiting in Los Angeles, California. Filter by phase, distance, and inclusion criteria to find cutting edge treatments & access premium care.

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Clinical Trials Clinical Trials in Los Angeles, CA

Phase-Based Progress Estimates

SLS-005for Spinocerebellar Ataxia Type 3

Los Angeles, CA

Los Angeles, CA

Phase 2b/3 double blind, randomized, placebo-controlled trial to assess safety and efficacy of SLS-005 (trehalose injection, 90.5 mg/mL for intravenous infusion) for the treatment of adults with spinocerebellar ataxia).

Phase-Based Progress Estimates

Focused Ultrasoundfor Familial Tremor

Los Angeles, CA

Los Angeles, CA

The purpose of this Phase I open label study is to evaluate longer term tolerability and potential effectiveness of transcranial ultrasound in people with tremor as a results of Parkinson's Disease or Essential Tremor.

Phase-Based Progress Estimates

Community Health Worker Led Curriculumfor Community Health Workers

Los Angeles, CA

Los Angeles, CA

The objective of this study is to compare the results of a COVID-19 specific curriculum led by LACDHS Community Health Workers (CHWs) from these same communities of safety-net patients to effectively increase COVID-19 testing and vaccination for individual patients, and to facilitate needed healthcare in a timely manner for the safety net health system, and to develop a sustained public health presence in these communities to build trust and preparedness for critical COVID-19 related future needs.

Phase-Based Progress Estimates

SPI-62 Dose1for Cushing Syndrome

This will be a randomized, double-blind study to evaluate the efficacy, safety, and pharmacological effect of SPI-62 in subjects with hypercortisolism related to a benign adrenal tumor.

Phase-Based Progress Estimates

Cabotegravir OLIfor HIV Infections

Los Angeles, CA

Los Angeles, CA

This is a two-arm study evaluating the impact of two implementation strategy conditions, dynamic implementation and routine implementation on the feasibility of delivering of Cabotegravir PrEP in low and high-volume PrEP sites in the United States for men who have sex with men (MSM) and Transgender men ≥ 18 years of age. There are two types of participants in the study. Patient Study Participants (PSPs) will refer to individuals who are enrolled in the study and who will receive commercially available Cabotegravir PrEP via prescription from the PrEP provider at the corresponding site. Staff Study Participants (SSPs) will refer to site staff who are involved in administrative and clinical aspects of offering and administering PrEP to PSPs and will participate in the staff study assessments.

Phase-Based Progress Estimates

Nirogacestatfor Ovarian Cancer

1 Prior Treatment

This phase 2 clinical trial will study the effectiveness of nirogacestat in ovarian granulosa cell tumors (OvGCTs). Nirogacestat is a gamma secretase inhibitor (GSI) which is hypothesized to decrease the growth and activity of ovarian granulosa tumors.

Phase-Based Progress Estimates

Obicetrapibfor Hypercholesterolemia

Los Angeles, CA

Waitlist Available

Los Angeles, CA

This study will be a placebo-controlled, double-blind, randomized, phase 2 study to evaluate the efficacy, safety, and tolerability of obicetrapib 10 mg, both in combination with ezetimibe 10 mg and as monotherapy, as an adjunct to high-intensity statin therapy.

Phase-Based Progress Estimates

Nirmatrelvirfor COVID-19

Washington, United States

Washington, United States

The purpose of this clinical trial is to learn about the safety, pharmacokinetics (pharmacokinetics helps us understand how the drug is changed and eliminated from your body after you take it), and efficacy (how well a study treatment works in the study) of the study medicine (called nirmatrelvir/ritonavir) for potential treatment of coronavirus disease 2019 (COVID-19). The study medicine will be given to patients under 18 years of age with COVID-19 that are not hospitalized but are at risk for severe disease.

Phase-Based Progress Estimates

Pembrolizumabfor Cancer of Oropharnyx

Los Angeles, CA

Los Angeles, CA

This phase II trial compares the effect of adding ipatasertib to pembrolizumab (standard immunotherapy) vs. pembrolizumab alone in treating patients with squamous cell cancer of the head and neck that has come back (recurrent) or has spread to other places in the body (metastatic). Ipatasertib is in a class of medications called protein kinase B (AKT) inhibitors. It may stop the growth of tumor cells and may kill them. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving ipatasertib in combination with pembrolizumab may be more effective than pembrolizumab alone in improving some outcomes in patients with recurrent/metastatic squamous cell cancer of the head and neck.

Phase-Based Progress Estimates

Photon Beam Radiation Therapyfor Glioblastoma

Newly Diagnosed

This phase III trial compares the effect of adding lomustine to temozolomide and radiation therapy versus temozolomide and radiation therapy alone in shrinking or stabilizing newly diagnosed MGMT methylated glioblastoma. Chemotherapy drugs, such as lomustine and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy photons to kill tumor cells and shrink tumors. Adding lomustine to usual treatment of temozolomide and radiation therapy may help shrink and stabilize glioblastoma.

Phase-Based Progress Estimates

20 Mg CBD + 20 Mg THC Cannabisfor Drug Abuse

Los Angeles, CA

Los Angeles, CA

This study is evaluating whether there are differences in the pharmacokinetics and pharmacodynamics of inhaled cannabis with varying amounts of THC, and CBD.

Phase-Based Progress Estimates

Nanoplexed Poly I:C BO-112for Carcinoma

Los Angeles, CA

Locally Advanced

Los Angeles, CA

This study is evaluating whether BO-112 and pembrolizumab may be effective in treating patients with liver cancer.

Phase-Based Progress Estimates

Prasinezumabfor Parkinsons Disease

Los Angeles, CA

Los Angeles, CA

This study is evaluating whether a drug may help people with Parkinson's disease.

Phase-Based Progress Estimates

Amniotic Suspension Allograftfor Arthrosis

Los Angeles, CA

Los Angeles, CA

This study is evaluating whether a common pain reliever may help treat knee pain associated with osteoarthritis.

Phase-Based Progress Estimates

Tirzepatidefor Type 2 Diabetes Mellitus

Waitlist Available

This study is evaluating whether a new drug may help improve blood sugar control in individuals with type 2 diabetes.

Phase-Based Progress Estimates

Elafibranor 80mgfor Liver Cirrhosis, Biliary

Los Angeles, CA

Los Angeles, CA

This study is evaluating whether a drug may help patients with primary biliary cholangitis.

Phase-Based Progress Estimates

Remdesivirfor COVID-19

Los Angeles, CA

Los Angeles, CA

This study is evaluating whether a new treatment may help critically ill patients.

Phase-Based Progress Estimates

Alpelisibfor Advanced HER2+Breast Cancer

Los Angeles, CA

Locally Advanced

Los Angeles, CA

This study is evaluating whether a drug may help treat breast cancer.

Phase-Based Progress Estimates

ASTX295for Tumors, Solid

Los Angeles, CA

Locally Advanced

Los Angeles, CA

This study is evaluating whether a drug may help treat tumors with a specific genetic mutation.

Phase-Based Progress Estimates

Pembrolizumabfor Pathologic Stage I Merkel Cell Carcinoma AJCC v8

This phase III trial studies how well pembrolizumab works compared to standard of care observation in treating patients with stage I-III Merkel cell cancer that has been completely removed by surgery (resected). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.

Phase-Based Progress Estimates

Cediranib Maleatefor Endometrioid Adenocarcinoma

Los Angeles, CA

Los Angeles, CA

This study is evaluating whether a combination of drugs may be more effective than a single drug in treating endometrial cancer.

Phase-Based Progress Estimates

Directional Deep Brain Stimulationfor Depression

Los Angeles, CA

1 Prior Treatment

Los Angeles, CA

This study is evaluating whether deep brain stimulation (DBS) can be used to treat depression.

Phase-Based Progress Estimates

SL-401for Leukemia, Myelomonocytic, Acute

Los Angeles, CA

Los Angeles, CA

This study is evaluating whether a drug may help treat chronic myelomonocytic leukemia or myelofibrosis.

Phase-Based Progress Estimates

Short-term Fastingfor Fasting in Malignant Solid Tumors

Los Angeles, CA

Waitlist Available

Locally Advanced

Los Angeles, CA

This study is evaluating whether fasting before chemotherapy may reduce the side effects caused by chemotherapy.

Phase-Based Progress Estimates

Paltusotinefor Acromegaly

A randomized, placebo-controlled study designed to evaluate the safety and efficacy of paltusotine (formerly CRN00808; an oral selective nonpeptide somatostatin receptor type 2 biased agonist) in subjects with non-pharmacologically treated acromegaly.

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