Treatment Resistant Depression

California

18 Treatment Resistant Depression Trials near California

Power is an online platform that helps thousands of Treatment Resistant Depression patients discover FDA-reviewed trials every day. Every trial we feature meets safety and ethical standards, giving patients an easy way to discover promising new treatments in the research stage.

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No Placebo
Highly Paid
Stay on Current Meds
Pivotal Trials (Near Approval)
Breakthrough Medication

Accelerated Theta Burst Stimulation for Suicidal Thoughts

San Diego, California
This trial is testing a new brain stimulation treatment to help people with hard-to-treat depression who have suicidal thoughts. The treatment uses magnetic pulses to stimulate specific brain areas several times. Researchers hope this will improve brain communication and reduce suicidal thoughts. This type of brain stimulation has been studied before and has shown positive effects.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased

76 Participants Needed

aiTBS for Depression

Palo Alto, California
This trial investigates whether aiTBS, a type of brain stimulation using magnetic fields, can help people with bipolar II disorder who haven't responded to other treatments. The treatment targets a specific brain area to improve mood and reduce depression. Accelerated intermittent theta burst stimulation (aiTBS) is a noninvasive neurostimulation technique that shows promise for improving clinical outcomes in treatment-resistant depression.

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased

60 Participants Needed

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Psychedelic-Assisted Therapy for Treatment Resistant Depression

Garden Grove, California
This study is testing VLS-01, a treatment containing DMT that is placed in the mouth and dissolved, to see if it can quickly help people with depression who haven’t improved with other treatments. Participants will receive either 1 or 3 doses of VLS-01, with support throughout the study, to evaluate its safety and effectiveness.

Trial Details

Trial Status:Recruiting
Trial Phase:Phase 2
Age:18 - 65

142 Participants Needed

Mindfulness Neurostimulation for Depression

La Jolla, California
Repetitive Transcranial Magnetic stimulation (rTMS) is an FDA-approved therapy for treatment resistant depression (TRD) that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region. But studies of rTMS alone show remission rates of ~30%. Additionally, rTMS has not been shown to improve cognitive functioning that may be an independent factor predicting treatment success. This study will develop a novel multimodal treatment, which combines intermittent theta burst stimulation (iTBS) - a type of rTMS with digital mindfulness training to engage brain plasticity, enhance cognition and alleviate depression symptoms in individuals with TRD.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Phase 2
Age:18 - 65

70 Participants Needed

Transcranial Magnetic Stimulation for Major Depression

San Diego, California
Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising intervention for treatment-resistant depression (TRD), yet substantial uncertainties persist regarding its efficacy as a maintenance treatment. This prospective study seeks to investigate the efficacy of maintenance rTMS in individuals with TRD who have previously responded to an acute course of rTMS. In the R61 phase of the study, we will recruit 75 participants across three study sites, the University of California San Diego, Weill Cornell Medicine, and Australian National University, into a double-blind, three-arm maintenance treatment trial. In this trial, participants will be randomized to receive either standard maintenance rTMS, clustered maintenance rTMS, or sham maintenance rTMS for a duration of 6 months. Our primary aim is to examine the efficacy of maintenance rTMS on sustaining connectivity between the dorsolateral prefrontal cortex (DLPFC) and subgenual cingulate cortex (SGC) measured through concurrent TMS and electroencephalography (TMS-EEG) at baseline and every six weeks throughout the 6-month treatment period. We will also assess changes in depressive symptom severity using clinical scales, including the Montgomery-Asberg Depression Rating Scale (MADRS) as a secondary outcome measure. It is hypothesized that stimulation with clustered maintenance rTMS will demonstrate superiority in sustaining DLPFC-SGC connectivity compared with standard maintenance rTMS and sham maintenance rTMS

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased

75 Participants Needed

Transcranial Direct Current Stimulation for Depression

San Diego, California
This study aims to evaluate the feasibility, safety, and tolerability of an innovative approach to treating Major Depressive Disorder (MDD), particularly in cases where patients have not responded well to traditional therapies. Specifically, the objective is to evaluate the antidepressant effects of a Dose-Optimized and Spaced Transcranial Direct Current Stimulation (DOS-tDCS) protocol in participants with treatment-resistant depression (TRD) compared to spaced tDCS only and sham tDCS in a 3-arm randomized controlled trial (RCT). The proposed method involves applying low-intensity electrical currents through the scalp in a manner that is both more intense and more frequently spaced than standard treatments. This approach is hypothesized to lead to a significant reduction in depressive symptoms. Participants in the study will be randomly assigned to one of three groups: the experimental group receiving the DOS-tDCS treatment, a group receiving spaced tDCS only, or a control group receiving a sham (placebo) treatment. Outcomes will be measured over a period of six weeks. The study's goal is to offer a potentially more accessible and effective treatment option for individuals who have not benefited from existing MDD therapies.

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased

75 Participants Needed

BPL-003 for Treatment Resistant Depression

San Francisco, California
This trial tests a nasal spray drug called BPL-003 along with counseling for people whose depression doesn't get better with usual treatments. The drug aims to quickly improve mood, and counseling helps provide emotional support.
No Placebo Group

Trial Details

Trial Status:Active Not Recruiting
Trial Phase:Phase 2

196 Participants Needed

Psilocybin for Depression

Palo Alto, California
The primary objective of this study is to evaluate the efficacy of psilocybin (25 mg) administered under supportive conditions to adult participants with severe TRD, in improving depressive symptoms.
No Placebo Group

Trial Details

Trial Status:Active Not Recruiting
Trial Phase:Phase 2
Age:18 - 65

27 Participants Needed

Theta Burst Stimulation for Treatment-Resistant Depression

La Jolla, California
In this proposal the investigators will use an accelerated TMS protocol that concentrates the magnetic stimulation that would usually occur over 6 weeks into 10 treatment sessions per days, for 5 consecutive days in patient with treatment-refractory depression. This protocol will build on a previously published study demonstrating clinical efficacy of intermittent theta-burst stimulation (iTBS) on left dorsolateral prefrontal cortex (L-dlPFC) in a treatment refractory population.
No Placebo Group

Trial Details

Trial Status:Active Not Recruiting
Trial Phase:Unphased

40 Participants Needed

Accelerated TMS for Depression

Stanford, California
This study evaluates an accelerated schedule of theta-burst stimulation using a transcranial magnetic stimulation device for treatment-resistant depression. In a double-blind, randomized, sham-controlled fashion, half the participants will receive accelerated theta-burst stimulation while half will receive sham treatment.

Trial Details

Trial Status:Active Not Recruiting
Trial Phase:Unphased
Age:22 - 65

100 Participants Needed

Accelerated Theta Burst for Treatment-Resistant Depression

Palo Alto, California
This trial tests a faster brain stimulation treatment for people with depression who don't respond to usual treatments. The treatment uses magnetic pulses to activate underactive brain areas and improve mood. This method has been explored as an alternative treatment for depression, particularly for patients who do not respond to usual treatments.
No Placebo Group

Trial Details

Trial Status:Enrolling By Invitation

90 Participants Needed

Psilocybin for Treatment-Resistant Depression

Thousand Oaks, California
This trial is testing a new medication called COMP360 to help people with severe depression that hasn't improved with other treatments. The study involves adults aged 18 and older. Researchers want to see if a single dose of COMP360 can reduce depression symptoms when given with psychological support.
Pivotal Trial (Near Approval)

Trial Details

Trial Status:Active Not Recruiting
Trial Phase:Phase 3

255 Participants Needed

Tianeptine for Depression

Stanford, California
This trial tests tianeptine, an antidepressant that targets specific brain receptors, on adults with major depressive disorder who haven't responded to other treatments. The goal is to see if tianeptine can help these patients by working on the brain's natural painkiller system. Tianeptine is known for its unique way of working and its ability to protect the brain from stress.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Phase 4
Age:21 - 60

75 Participants Needed

Neuromodulation for Treatment-Resistant Depression

Stanford, California
This study will investigate the anti-anhedonic efficacy of a novel neurostimulation strategy termed accelerated intermittent theta burst stimulation (aiTBS) in participants with treatment resistant depression (TRD).

Trial Details

Trial Status:Active Not Recruiting
Trial Phase:Unphased

79 Participants Needed

Deep Brain Stimulation Surgery for Treatment Resistant Depression

Los Angeles, California
Treatment resistant depression remains a major problem for individuals and society. Surgical procedures may provide relief for some of these patients. The most frequently considered surgical approach is deep brain stimulation (DBS) of a part of the brain called the subcallosal cingulate region. However, the effectiveness and safety is not well established. The investigators will use a novel approach using advanced imaging technique (magnetic resonance tractography) to evaluate the feasibility and safety of this surgical approach. An innovative method for the definition of DBS target will be applied that redefines the concept of targeting as one of targeting a symptomatic network rather than a structural brain region using subject-based brain anatomy to define the target location. The correlation between imaging findings at baseline with the mood score changes at different time points of the study will be investigated.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased
Age:21 - 70

12 Participants Needed

Therapeutic Neuromodulation for Depression

Stanford, California
This study will investigate the anti-anhedonic efficacy of a novel neurostimulation strategy termed accelerated intermittent theta burst stimulation (aiTBS) in participants with treatment resistant depression (TRD).
No Placebo Group

Trial Details

Trial Status:Active Not Recruiting
Trial Phase:Unphased

16 Participants Needed

Rapid-Acting TMS for Depression

Stanford, California
This study evaluates an accelerated schedule of theta-burst stimulation using a transcranial magnetic stimulation device for treatment-resistant depression. In a double-blind, randomized, sham-controlled fashion, half the participants will receive accelerated theta-burst stimulation while half will receive sham treatment.

Trial Details

Trial Status:Active Not Recruiting
Trial Phase:Unphased
Age:22 - 65

100 Participants Needed

Deep Brain Stimulation for Depression

San Francisco, California
Neurons are specialized types of cells that are responsible for carrying out the functions of the brain. Neurons communicate with electrical signals. In diseases such as major depression this electrical communication can go awry. One way to change brain function is using electrical stimulation to help alter the communication between groups of neurons in the brain. The purpose of this study is to test a personalized approach to brain stimulation as an intervention for depression. The study researchers will use a surgically implanted device to measure each individual's brain activity related to his/her depression. The researchers will then use small electrical impulses to alter that brain activity and measure whether these changes help reduce depression symptoms. This study is intended for patients with major depression whose symptoms have not been adequately treated with currently available therapies. The device used in this study is called the NeuroPace Responsive Neurostimulation (RNS) System. It is currently FDA approved to treat patients with epilepsy. The study will test whether personalized responsive neurostimulation can safely and effectively treat depression.

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased
Age:22 - 70

12 Participants Needed

Why Other Patients Applied

"I'm taking a medication for anxiety and it's not helping/working. I want to try and find something that would help with my anxiety. My research brought me to clinical trials."

ZD
Anxiety PatientAge: 36

"I've tried 8 or 9 different combinations of antidepressants (SSRI, SNRI, etc) + antipsychotics, mood stabilizers, anxiolytics... I’ve been through on- and off-label treatments, I've had at least 4 serious side effcts in the 10 years I've been on antidepressants. I've done PGx testing for genetic markers, too. My experience finding appropriate treatment has been lonely, exhausting. I'd love to participate in something that helps others like me."

HZ
Treatment-Resistant Depression PatientAge: 31

"I’ve tried so many drugs and treatments for depression it won’t go away or if it does it just comes back. I want to help others who may have this awful condition while also helping myself. If something new works for me, maybe it'll work for other people too."

WK
Depression PatientAge: 56

"I tried Prozac, Lamictal, TMS, a psychotherapy, and mindfulness meditation. These treatments provided limited relief. I hope for a new treatment that will be more effective. Looking for something that lasts long-term so that I can get my life back."

HY
Depression PatientAge: 63

"I've heard great things about ketamine for treatment resistant depression and PTSD but haven't been able to try it. I've been struggling to find something to alleviate my symptoms since my son passed away in 2017."

XB
Treatment-Resistant Depression PatientAge: 54

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How Do Clinical Trials Work?Are Clinical Trials Safe?What Can I Expect During a Clinical Trial?

Frequently Asked Questions

How much do Treatment Resistant Depression clinical trials in California pay?

Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range for Phase 2–4 trials (Phase 1 trials often pay substantially more). Further, most trials will cover the costs of a travel to-and-from the clinic.

How do Treatment Resistant Depression clinical trials in California work?

After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll be sorted into one of the treatment groups, and receive your study drug. For some trials, there is a chance you'll receive a placebo. Across Treatment Resistant Depression trials in California 30% of clinical trials have a placebo. Typically, you'll be required to check-in with the clinic every month or so. The average trial length in California for Treatment Resistant Depression is 12 months.

How do I participate in a study as a "healthy volunteer"?

Not all studies recruit healthy volunteers: usually, Phase 1 studies do. Participating as a healthy volunteer means you will go to a research facility in California several times over a few days or weeks to receive a dose of either the test treatment or a "placebo," which is a harmless substance that helps researchers compare results. You will have routine tests during these visits, and you'll be compensated for your time and travel, with the number of appointments and details varying by study.

What does the "phase" of a clinical trial mean?

The phase of a trial reveals what stage the drug is in to get approval for a specific condition. Phase 1 trials are the trials to collect safety data in humans. Phase 2 trials are those where the drug has some data showing safety in humans, but where further human data is needed on drug effectiveness. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. As a general rule, Phase 3 trials are more promising than Phase 2, and Phase 2 trials are more promising than phase 1.

Do I need to be insured to participate in a Treatment Resistant Depression medical study in California?

Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.

What are the newest Treatment Resistant Depression clinical trials in California?

Most recently, we added Transcranial Magnetic Stimulation for Major Depression, VLS-01 Buccal Film for Depression and Transcranial Direct Current Stimulation for Depression to the Power online platform.

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