← Back to Search

EHR Alert + Structured Communication for Pneumonia (UP-CAPTAIn Trial)

N/A

Recruiting

Led By Daniel J. Morgan, MD, MS

Research Sponsored by Jonathan Baghdadi

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 days after randomization.

Awards & highlights

UP-CAPTAIn Trial Summary

This trial aims to improve antibiotic use in hospital patients with possible pneumonia, using an EHR alert and structured communication to de-escalate antibiotics if test results suggest viral infection.

Who is the study for?

This trial is for adult patients at two Maryland medical centers who are hospitalized with suspected community-acquired respiratory infections and have test results that may indicate a viral infection. They must be on antibiotics and not just have cold symptoms.Check my eligibility

What is being tested?

The study tests if an electronic alert in the health record, advising doctors based on the likelihood of bacterial pneumonia, can improve antibiotic use. Patients flagged as likely having a virus will either get special advice to reduce antibiotics or continue with standard care.See study design

What are the potential side effects?

Since this trial focuses on improving antibiotic use rather than testing new drugs, side effects relate to potential misuse of antibiotics such as allergic reactions, gastrointestinal issues, or increased resistance to antibiotics.

UP-CAPTAIn Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 days after randomization.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 days after randomization.

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 days after randomization. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Hospital antibiotic days of therapy

Secondary outcome measures

Acute kidney injury

Antibiotic de-escalations within 72 hours after initiation

C. difficile infections in the 30-days post-randomization

+5 more

UP-CAPTAIn Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Electronic alert plus structured communication of test resultsExperimental Treatment2 Interventions

An electronic health record alert will guide diagnostic testing for pneumonia. For patients with low or moderate probability of bacterial pneumonia, test results will be communicated to the primary team with guidance to consider discontinuing or de-escalating antibiotics.

Group II: Electronic alert without structured communication of test resultsActive Control1 Intervention

An electronic health record alert will guide diagnostic testing for pneumonia. The primary care team will access and interpret test results and decide upon composition and duration of antimicrobial without external guidance.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Jonathan BaghdadiLead Sponsor

Centers for Disease Control and PreventionFED

875 Previous Clinical Trials

22,477,302 Total Patients Enrolled

Daniel J. Morgan, MD, MSPrincipal InvestigatorUniversity of Maryland, Baltimore

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research endeavor currently recruiting volunteers?

"As per clinicaltrials.gov, this trial is still actively seeking participants. The study was originally posted on November 1st 2023 and the information was last updated one month later on December 1st 2023."

Answered by AI

How many individuals are participating in this experiment?

"Indeed, the records available on clinicaltrials.gov demonstrate that this study is actively enlisting patients. Launched on November 1st 2023, it has since been updated and requires 1500 participants from 2 different centers of treatment."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Using Probability of Community-Acquired Pneumonia to Tailor Antimicrobials Among Inpatients

Jonathan Baghdadi 2023. "Using Probability of Community-Acquired Pneumonia to Tailor Antimicrobials Among Inpatients". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05976581.