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Procedure
Laser Ablation for Thyroid Cancer
Phase 2
Recruiting
Led By R. Michael Tuttle, MD
Research Sponsored by Memorial Sloan Kettering Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Preserved contralateral vocal cord function prior to PLA
Age ≥ 18 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights
Study Summary
This trial will test whether laser ablation is a safe and effective alternative to surgery for removing very small thyroid tumors.
Who is the study for?
This trial is for adults with a small thyroid cancer (≤13mm) called papillary thyroid microcarcinoma, who haven't spread to lymph nodes or beyond the thyroid capsule. It's for those who've declined just watching the tumor and have certain cancer cell characteristics confirmed by tests.Check my eligibility
What is being tested?
The study is testing percutaneous laser ablation (PLA), which uses lasers to destroy tumors without surgery, as a treatment option for removing tiny papillary thyroid cancers instead of traditional surgery.See study design
What are the potential side effects?
While not explicitly listed in your information, PLA may cause pain at the injection site, swelling, bruising, infection risk at the needle entry point and potential damage to surrounding tissues.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
My other vocal cord works fine before the procedure.
Select...
I am 18 years old or older.
Select...
I have chosen not to undergo active surveillance for my condition.
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My thyroid cancer diagnosis is confirmed by specific tests and features.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 6 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Number of participants with complete thermal ablation
Trial Design
1Treatment groups
Experimental Treatment
Group I: Participants with papillary microcarcinoma (PTMC)Experimental Treatment1 Intervention
Participants with papillary microcarcinoma (PTMC) who have elected to proceed with thyroidectomy rather than an observational management approach will be considered as potential candidates for this trial.
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Who is running the clinical trial?
Memorial Sloan Kettering Cancer CenterLead Sponsor
1,936 Previous Clinical Trials
588,888 Total Patients Enrolled
3 Trials studying Thyroid Carcinoma
80 Patients Enrolled for Thyroid Carcinoma
R. Michael Tuttle, MDPrincipal InvestigatorMemorial Sloan Kettering Cancer Center
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Eligibility Criteria:
This trial includes the following eligibility criteria:- My other vocal cord works fine before the procedure.The size of the maximum diameter of something should be 13 millimeters or less.My cancer has spread to my lymph nodes.Your medical scans do not show any signs of cancer spreading to the lymph nodes.I am 18 years old or older.Your thyroid lesion has more than 25% cysts in it.I have chosen not to undergo active surveillance for my condition.My thyroid cancer is not the papillary type.Your thyroid has grown outside of its normal area, as shown by ultrasound.The thyroid growth must be mostly solid with less than 25% being a fluid-filled sac.My thyroid cancer diagnosis is confirmed by specific tests and features.There is no sign that the cancer has spread outside the thyroid gland in the US imaging.
Research Study Groups:
This trial has the following groups:- Group 1: Participants with papillary microcarcinoma (PTMC)
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is this research program still recruiting participants?
"Yes, this study is still open and looking for willing participants. According to the website clinicaltrials.gov, recruitment began on October 19th, 2020 with the most recent update to the posting being made on July 14th, 2022."
Answered by AI
How many different people are included in this research project?
"The clinicaltrials.gov website says that this trial is open for enrollment and looking for 10 patients at 1 site. The posting date was October 19th 2020, with the most recent update on July 14th, 2022."
Answered by AI
Is Percutaneous Laser Ablation (PLA) an accepted medical treatment by the FDA?
"Percutaneous Laser Ablation (PLA) is still being studied in Phase 2 trials, so there is only some data supporting its safety. None of the clinical trials done thus far have looked at PLA's efficacy."
Answered by AI
Who else is applying?
What state do they live in?
California
How old are they?
18 - 65
What site did they apply to?
Memorial Sloan Kettering Cancer Center
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0
Why did patients apply to this trial?
From my research, I am a strong advocate of Ablation Therapy.
PatientReceived 2+ prior treatments
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