Diet intervention for Hypertriglyceridemia

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Nemours Cardiac Center, Nemours Children's Hospital Delaware, Wilmington, DE
Hypertriglyceridemia
Diet intervention - Other
Eligibility
< 18
All Sexes
What conditions do you have?
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Study Summary

This study is evaluating whether a diet rich in omega-3 fatty acids can improve triglyceride levels in people with hypertriglyceridemia.

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Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

This trial is evaluating whether Diet intervention will improve 1 primary outcome and 1 secondary outcome in patients with Hypertriglyceridemia. Measurement will happen over the course of 8 weeks.

8 weeks
change in serum triglyceride level after an 8-week diet intervention compared to baseline
change red blood cell omega-3 fatty acid content / index after an 8-week diet intervention compared to baseline

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

Standard lifestyle intervention
1 of 2
Standard lifestyle intervention + omega-3 fatty acid enriched diet
1 of 2
Active Control
Experimental Treatment

This trial requires 40 total participants across 2 different treatment groups

This trial involves 2 different treatments. Diet Intervention is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Standard lifestyle intervention + omega-3 fatty acid enriched diet
Other
American Heart Association Target Diet/Standard Lifestyle Intervention (SLI) + omega-3 fatty acid enriched foods
Standard lifestyle intervention
Other
American Heart Association Target Diet/Standard Lifestyle Intervention (SLI)

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 8 weeks
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 8 weeks for reporting.

Closest Location

Nemours Cardiac Center, Nemours Children's Hospital Delaware - Wilmington, DE

Eligibility Criteria

This trial is for patients born any sex aged 18 and younger. There are 5 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
People with a clinical serum triglyceride level of more than 150 mg/dl and less than 500 mg/dl within three months to one week prior to their study visit 1 were included in the study. show original
Male or female patients who are 10 -17 years of age
Ability to follow the study procedures and adhere to the diet counseling recommendations
Written parental permission and assent are obtained prior to any research procedures
and less than the 95th percentile is considered overweight show original

Patient Q&A Section

What is the average age someone gets hypertriglyceridemia?

"In the United States, hypertriglyceridemia is common in people from 4.8 to 29 years old. Higher rates of hypertriglyceridemia and higher total cholesterol levels occur when there is a greater degree of obesity or a lower degree of physical activity." - Anonymous Online Contributor

Unverified Answer

How many people get hypertriglyceridemia a year in the United States?

"There is an urgent need to better define and characterize what causes hypertriglyceridemia in the U.S. and to develop a public education and program to reduce the prevalence of this condition. A national surveillance system is needed to define the prevalence and to determine the causes of elevated levels of this lipid abnormality." - Anonymous Online Contributor

Unverified Answer

Can hypertriglyceridemia be cured?

"Hypertriglyceridemia cannot be treated. However, lowering it to a lower target and maintaining it there will result in an improvement to a significant extent, particularly in patients with high levels." - Anonymous Online Contributor

Unverified Answer

What are the signs of hypertriglyceridemia?

"Hypertriglyceridemia is frequently asymptomatic, and most people would think hypertriglyceridemia may be caused by overweight or obesity, which is the most common cause. It is important to clarify the etiological mechanism of hypertriglyceridemia." - Anonymous Online Contributor

Unverified Answer

What is hypertriglyceridemia?

"In contrast to previous reports in the literature using a different methodology, we found no evidence of an increased risk of the development of type 2 diabetes in patients presenting with elevated TG." - Anonymous Online Contributor

Unverified Answer

What causes hypertriglyceridemia?

"Hypertriglyceridemia is common in the population and not related to a single cause. Hypertriglyceridemia is more common in those who suffer from more severe coronary artery disease and also among smokers." - Anonymous Online Contributor

Unverified Answer

What are common treatments for hypertriglyceridemia?

"No single treatment approach seems superior. In particular, in the short term, weight loss may be effective. But, there is a shortage of trials of long-term treatment options. Meta-analytical techniques are not useful to decide which therapies to use. This report also discusses the controversies in treating hypertriglyceridemia." - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating hypertriglyceridemia?

"There has been no new discovery of a medication that can help treat the problem of hypertriglyceridemia. There is no compelling evidence that an individual's genetic makeup dictates whether they will develop hypertriglyceridemia and the condition is a huge burden on their lifestyles. Since there is no evidence-based treatment drug for hypertriglyceridemia, it is imperative that we continue to perform research to figure out the cause of the condition, how to prevent and treat individuals, and learn more about the condition as a whole." - Anonymous Online Contributor

Unverified Answer

What is the latest research for hypertriglyceridemia?

"Hypertriglyceridemia is an important factor for cardiovascular diseases, type 2 diabetes, and cardiovascular mortality (Heart Disease and Stroke). Although lipid-lowering therapies have been effective in lowering total cholesterol and LDL levels, they have only limited effects on reducing the risk of heart disease and stroke. The lipid-lowering drugs currently used have not fully resolved the problem of hypertriglyceridemia. New, effective drugs for lipid-lowering therapy are needed." - Anonymous Online Contributor

Unverified Answer

Have there been other clinical trials involving diet intervention?

"As of 2011, no placebo or comparator control studies have been performed for the diet intervention trials of chronic diseases. This may represent one of the biggest gaps in the field of diet-related intervention trials. The following represents a preliminary review of some possible solutions to this problem." - Anonymous Online Contributor

Unverified Answer

How does diet intervention work?

"The diet intervention did not impact on cardiovascular risk factors, lipid profiles, blood cell subtypes, circulating platelet activation markers, platelet function, inflammation, or blood sugar levels in subjects with NRTW. The primary outcome was not superior for subjects with a diet change compared to standard care." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of diet intervention?

"Despite high adherence, many of the side effects of diet supplementation seem to be unavoidable. These side effects are associated with dietary and metabolic disturbances in the context of an altered insulin metabolism." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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