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Arm I (alteplase) for Blood Cancers

N/A
Recruiting
Led By Horiana Grosu, M D
Research Sponsored by M.D. Anderson Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion; an average of 1 year
Awards & highlights

Study Summary

This study investigates whether alteplase can help to improve pleural fluid drainage and dyspnea (breathlessness) in patients with non-draining malignant pleural effusion. Alteplase helps dissolve blood clots and is used to treat heart attacks, strokes, and clots in the lungs. Alteplase may help to control symptoms of breathlessness.

Eligible Conditions
  • Cancer
  • Blood Cancers

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion; an average of 1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion; an average of 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events

Trial Design

2Treatment groups
Experimental Treatment
Group I: Arm II (placebo)Experimental Treatment1 Intervention
Patients receive placebo instilled into the IPC which is capped for 1-2 hours before the catheter is drained. Beginning 1 week later, patients may receive alteplase as in arm I.
Group II: Arm I (alteplase)Experimental Treatment1 Intervention
Patients receive alteplase instilled into the IPC which is capped for 1-2 hours before the catheter is drained.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Placebo Administration
2018
Completed Phase 3
~2540
Alteplase
2006
Completed Phase 4
~7390

Find a Location

Who is running the clinical trial?

M.D. Anderson Cancer CenterLead Sponsor
2,966 Previous Clinical Trials
1,804,751 Total Patients Enrolled
Horiana Grosu, M DPrincipal InvestigatorM.D. Anderson Cancer Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Alteplase Through an Indwelling Pleural Catheter for the Management of Symptomatic Septated Malignant Pleural Effusion
2023. "Alteplase Through an Indwelling Pleural Catheter for the Management of Symptomatic Septated Malignant Pleural Effusion". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06184321.
All > Paid Studies Houston > Paid Studies Pasadena
~20 spots leftby Feb 2027
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