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Procedure

1 for Dry Eye Syndrome

N/A
Waitlist Available
Led By Richard D Stutzman, MD
Research Sponsored by Walter Reed National Military Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up one year after surgery
Awards & highlights

Study Summary

Purpose: To develop a screening metric by examining both the characteristics of the preoperative tear film and the intracellular signaling pathways of conjunctival goblet cells in order to determine if there are certain characteristics which might predict those patients who will experience serious dry eye symptoms and complications after refractive surgery. Research Design: This study is a twelve-month prospective non-randomized investigation. Methodology: In conjunction with psychometric questionnaires and various measures of tear film quality (e.g. Schirmer's test, tear break up time, etc), impression cytology will be used to assess the intracellular signaling pathways of conjunctival goblet cells and to determine if alterations in this pathway exist. Alterations in this pathway would result in a reduced response by the mucin secreting conjunctival goblet cells thereby promoting the development of dry eye after refractive surgery.

Eligible Conditions
  • Dry Eye Syndrome

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~one year after surgery
This trial's timeline: 3 weeks for screening, Varies for treatment, and one year after surgery for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Dry eye

Trial Design

2Treatment groups
Active Control
Group I: 1Active Control1 Intervention
PRK
Group II: 2Active Control1 Intervention
LASIK

Find a Location

Who is running the clinical trial?

Walter Reed National Military Medical CenterLead Sponsor
138 Previous Clinical Trials
33,868 Total Patients Enrolled
Schepens Eye Research InstituteOTHER
3 Previous Clinical Trials
195 Total Patients Enrolled
State University of New York College of OptometryOTHER
19 Previous Clinical Trials
990 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Goblet Cell Response and Dry Eye Symptoms After PRK and LASIK
Samanta B. Rodgers 2008. "Goblet Cell Response and Dry Eye Symptoms After PRK and LASIK". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00411827.
All > Dry Eye
~8 spots leftby May 2025
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