Baduanjin Exercise for Cognitive Decline

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Massachusetts General Hospital, Charlestown, MA
Cognitive Decline+1 More
Baduanjin Exercise - Other
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a simple mind-body exercise can help improve cognitive function in individuals with subjective cognitive decline.

See full description

Eligible Conditions

  • Cognitive Decline

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

This trial is evaluating whether Baduanjin Exercise will improve 2 primary outcomes and 14 secondary outcomes in patients with Cognitive Decline. Measurement will happen over the course of baseline, 3, 6 months.

baseline, 3, 6 months
Brain morphometry
Functional connectivity of hippocampus and DLPFC
Month 9
Alzheimer Disease Cooperative Study- Preclinical Alzheimer (ADCS-PACC) Cognitive Composite
Beck Anxiety Inventory (BAI)
Blood markers
Brief Quantitative Sensory Testing (QST)
Controlled Oral Word Association Test, Category Fluency and Category Switching
Everyday Cognition -Subject/Self Report Form (ECog-self report and informant)
Heart rate variability
Modified Brief Pain Inventory (BPI)
Patient Reported Outcomes Measurement Information System - Cognition Function and ability subset
Patient Reported Outcomes Measurement Information System 29 (PROMIS-29)
Symbol Digit Modalities Test (SDMT)
The California Verbal Learning Test-II (CVLT-II)
The Stroop Color and Word Test (SCWT)
Trail-making Test A and B

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

Cognitive Fitness Program
1 of 2
Baduanjin
1 of 2
Active Control
Experimental Treatment

This trial requires 120 total participants across 2 different treatment groups

This trial involves 2 different treatments. Baduanjin Exercise is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Baduanjin
Other
This group will participate in the Baduanjin exercise intervention for 24 weeks (three times/week for the first three months and two times/week for the last three months).
Cognitive Fitness Program
Other
This group will participate in the Cognitive Fitness Program intervention for 24 weeks (three times/week for the first three months and two times/week for the last three months).

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, 3, 6, 9 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly baseline, 3, 6, 9 months for reporting.

Who is running the study

Principal Investigator
J. K.
Prof. Jian Kong, Associate Professor
Massachusetts General Hospital

Closest Location

Massachusetts General Hospital - Charlestown, MA

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 6 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Concerns regarding memory problems
Self-reported experience of persistent decline in memory compared with a previous state (within the past 5 years), which was further confirmed by informants
Mini-Mental State Examination, Second Edition (MMSE-2) scores within the normal range
Montreal Cognitive Assessment scores within the normal range (adjusted for age, sex, and education)
50 - 80 years old
Clinical Dementia Rating score of 0 (no memory loss or slight, inconsistent forgetfulness)

Patient Q&A Section

What are common treatments for cognitive decline?

"Many common treatments for cognitive decline have been studied yet are not proven effective. Additional research with prospective data is needed for evidence-based guidelines to be set." - Anonymous Online Contributor

Unverified Answer

What is cognitive decline?

"Cognitive decline can occur independently of age and is related to poorer functional status in older people with a variety of chronic diseases. Data from a recent study shows that cognitive impairment is highly prevalent and can cause important psychological difficulties for older people with chronic diseases. The findings may have important implications for the development of interventions and quality of life measures that target cognitive dysfunction." - Anonymous Online Contributor

Unverified Answer

What are the signs of cognitive decline?

"Data from a recent study suggest that common non-neuropsychological factors can significantly affect the quality of life in patients with a variety of medical conditions, especially aging and multimorbidity. Cognitive decline is a common complaint in the community, and therefore, it should be added to the medical records of patients with different medical conditions." - Anonymous Online Contributor

Unverified Answer

How many people get cognitive decline a year in the United States?

"It is estimated that 1.4 million Americans will meet the criteria for early Alzheimer's disease in the year 2016. Older individuals, especially those with normal cognition, may be at increased risk for cognitive decline and progression to Alzheimer's disease." - Anonymous Online Contributor

Unverified Answer

What causes cognitive decline?

"Some forms of cognitive decline, such as loss of memory, may be induced by genetics; others, such as memory problems, may be caused by lifestyle factors, medication, or a combination of both." - Anonymous Online Contributor

Unverified Answer

Can cognitive decline be cured?

"Cognitive decline caused by aging or by a disease like Alzheimer's can be slowed or prevented by preventive lifestyle changes, by optimizing cognitive performance and by pharmacologic and nonpharmacologic enhancement of cognitive function." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets cognitive decline?

"The average age for cognitive decline is 85. A 2016 study found that, compared to the general elderly population, those with dementia or Alzheimer disease have an [average age of dementia onset at 90.8 years old (range 81.8–97.7) and Alzheimer disease onset at 78.0 years old (range 50.1–88.4)] (http://onlinelibrary.wiley.com/doi10.1111/ajmg.1207/abstract). Another 2016 study found that patients have a mean age of onset for dementia of 76.9 (range 64–94) but once it progresses to Alzheimer's disease, it is on average only 1.1 years (range 0.6–1." - Anonymous Online Contributor

Unverified Answer

Is baduanjin exercise safe for people?

"Recent findings indicates that the safety of an exercise program including Baduanjin therapy should be considered to treat cognitive decline in old age and to prevent the development of Alzheimer's disease." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in baduanjin exercise for therapeutic use?

"Baduanjin exercise has the potential to reduce cognitive impairment and dementia, and may help improve the function of the nervous system, especially for treating patients with dementia and other neurological diseases. It is useful to determine the appropriate therapeutic method for using baduanjin exercise in the clinic and in the home." - Anonymous Online Contributor

Unverified Answer

What is the latest research for cognitive decline?

"Cognitive decline is a large concern, a major component in patient care, and a topic of national debate, particularly among health professionals. Although our review indicates substantial progress, much of the information available on the subject is inconclusive or lacks empirical evidence. We highlight the need for further clinical trials and research into the management of brain ageing through pharmacological and nonpharmacological approaches." - Anonymous Online Contributor

Unverified Answer

What is baduanjin exercise?

"Baduanjin exercise can improve cognitive function and reduce the brain amyloid precursor protein pathology in senile mice. Moreover, baduanjin exercise improves the cognitive function in mouse models for age and AD, which may improve their social function and prevent memory loss." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of baduanjin exercise?

"This is one of the first reports to show that baduanjin could be useful as a therapeutic agent for the dementia prevention in healthy elderly subjects." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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