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Online Wellness Interventions for Cognitive Impairment (MOTION Trial)

N/A
Waitlist Available
Led By Linda L Chao, PhD
Research Sponsored by University of California, San Francisco
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Capacity to provide informed consent or legally authorized representative consent and participant assent.
Age ≥ 55 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline to 6 months after treatment ends.
Awards & highlights

MOTION Trial Summary

This trial will compare the effects of three different online wellness interventions on improving physical and cognitive function and brain connectivity in adults experiencing memory or cognitive difficulties.

Who is the study for?
Adults over 55 with mild cognitive impairment (MoCA score <26) and subjective memory complaints can join this trial. They must speak English, have internet at home, and be able to travel to specific California locations for assessments. Exclusions include severe disabilities, insufficient English proficiency, life expectancy concerns, other study participation, recent psychoactive medication changes or dementia diagnosis.Check my eligibility
What is being tested?
The MOTION study is testing three online wellness programs: Health and Wellness Education, Tai Chi exercises, and PLIE training. These are aimed at improving physical function, cognition, and brain connectivity in older adults with memory or cognitive issues.See study design
What are the potential side effects?
Since the interventions involve non-invasive activities like education and exercise programs rather than medications or medical procedures, significant side effects are not expected. However participants may experience typical exercise-related discomfort.

MOTION Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I can make my own medical decisions or have someone who can.
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I am 55 years old or older.
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I am 55 years old or older.

MOTION Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline to 6 months after treatment ends.
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline to 6 months after treatment ends. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Alzheimer's Disease
Change in Default Mode Network (DMN) functional connectivity
Secondary outcome measures
Change in Attention/Executive Function Cognitive Domain Scores
Change in Auditory Memory scores
Change in Language Network functional connectivity
+4 more
Other outcome measures
Change in PROMIS-29 Health-Related Quality of Life (HRQoL) Domains
Change in a measure of mindfulness
Change in measures of body awareness

Side effects data

From 2018 Phase 2 & 3 trial • 88 Patients • NCT02350127
34%
Not serious
16%
Other AE
14%
Hospitalization
5%
Life-threatening
2%
Procedures
100%
80%
60%
40%
20%
0%
Study treatment Arm
Immediate Start
Delayed Start

MOTION Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: Tai ChiExperimental Treatment1 Intervention
Participants will engage in 60-minute Tai Chi classes twice a week for 12 weeks. The classes will be live-streamed over the internet. Tai Chi is an ancient Chinese system of gentle physical exercise and stretching. It involves a series of movements performed in a slow, focused manner and accompanied by deep breathing.
Group II: Gentle, Mindful MovementExperimental Treatment1 Intervention
Participants will engage in a gentle, mindful movement class twice a week for 12 weeks. The classes will be one hour long and will be live-streamed over the internet. The mindful movement classes will combine elements from a wide range of Eastern and Western exercise modalities, including occupational therapy, physical therapy, yoga, tai chi, Feldenkrais, Rosen Method, dance movement therapy and mindfulness meditation.
Group III: Health and Wellness EducationActive Control1 Intervention
Participants will engage in bi-weekly 60 minute sessions of Health and Wellness Education classes. The classes will be held on-line for 12 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Preventing Loss of Independence through Exercise (PLIE)
2015
Completed Phase 3
~90
Tai Chi
2014
Completed Phase 2
~1660

Find a Location

Who is running the clinical trial?

United States Department of DefenseFED
861 Previous Clinical Trials
227,114 Total Patients Enrolled
University of California, San FranciscoLead Sponsor
2,500 Previous Clinical Trials
15,236,391 Total Patients Enrolled
University of California, Los AngelesOTHER
1,528 Previous Clinical Trials
10,276,771 Total Patients Enrolled

Media Library

Health and Wellness Education Clinical Trial Eligibility Overview. Trial Name: NCT05217849 — N/A
Mild Cognitive Impairment Research Study Groups: Tai Chi, Gentle, Mindful Movement, Health and Wellness Education
Mild Cognitive Impairment Clinical Trial 2023: Health and Wellness Education Highlights & Side Effects. Trial Name: NCT05217849 — N/A
Health and Wellness Education 2023 Treatment Timeline for Medical Study. Trial Name: NCT05217849 — N/A
Mild Cognitive Impairment Patient Testimony for trial: Trial Name: NCT05217849 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What outcome is this research aiming to attain?

"This trial will measure the Change from baseline to 6 months after treatment ends of Default Mode Network (DMN) functional connectivity as its primary outcome. Secondary outcomes encompass Verbal Fluency scores, Processing Speed Scores, and Mobility; all assessed with standardised tests such as Controlled Oral Word Association test (FAS), Digit Symbol Substitution Test (DSST) and Timed Up and Go (TUG). Raw scores are transformed into z-scores for each participant, where higher values represent better performance."

Answered by AI

Is this study currently accepting participants?

"Affirmative. According to the information presented on clinicaltrials.gov, this research initiative is still open for recruitment. Initially posted on February 15th 2022 and last updated a week later, it requires 80 participants from one location."

Answered by AI

How many subjects are being monitored in this research endeavor?

"Affirmative. Information posted on clinicaltrials.gov affirms that this medical investigation is accepting new participants. It was first listed on February 15th 2022 and has since been updated, suggesting a need for 80 patients from 1 site to join the trial."

Answered by AI

Who else is applying?

What state do they live in?
Illinois
Arizona
California
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0
2
What site did they apply to?
VA Health Care System

Why did patients apply to this trial?

I have not tried any memory drugs.
PatientReceived 2+ prior treatments

How responsive is this trial?

Typically responds via
Phone Call
Recent research and studies
clinicaltrials.govStudy
Multi-domain Online Therapeutic Investigation Of Neurocognition (MOTION)
2022. "Multi-domain Online Therapeutic Investigation Of Neurocognition (MOTION)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05217849.
~35 spots leftby Dec 2025
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