Treatment for Hypermetria

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Johns Hopkins University School of Medicine, Baltimore, MD
Hypermetria+2 More
Eligibility
18+
All Sexes
What conditions do you have?
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Study Summary

This project will study the feasibility of motor rehabilitation in people with cerebellar ataxia using real-time functional magnetic resonance imaging neurofeedback (rt-fMRI NF) in conjunction with motor imagery. To do so, data will be collected from healthy adults in this protocol, to be compared with data from cerebellar ataxia participants.

Eligible Conditions

  • Hypermetria
  • Healthy Subjects (HS)

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

4 Primary · 4 Secondary · Reporting Duration: Baseline and At-home sessions (10 minutes/day), up to 23 days

Day 23
Change in at-home overt tapping accuracy as assessed by finger tapping to a flashing cue at 1Hz speed
Change in at-home overt tapping accuracy as assessed by finger tapping to a flashing cue at 4Hz speed
Hour 1
Change in overt tapping accuracy as assessed by finger tapping to a flashing cue at 1Hz speed
Change in overt tapping accuracy as assessed by finger tapping to a flashing cue at 4Hz speed
Hour 1
The correlation between MRI BOLD and finger tapping accuracy to a flashing cue at 1Hz as assessed by a correlation coefficient
The correlation between MRI BOLD and finger tapping accuracy to a flashing cue at 4Hz as assessed by a correlation coefficient
Up to 1.5 hours
The correlation between the ICARS and imagery accuracy of the slider bar from target on the MRI task as assessed by a correlation coefficient
The correlation between the KVIQ and imagery accuracy of the slider bar from target on the MRI task as assessed by a correlation coefficient

Trial Safety

Safety Progress

1 of 3

Trial Design

0 Treatment Group

30 Total Participants · 0 Treatment Group

Primary Treatment: Treatment · No Placebo Group · N/A

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline and at-home sessions (10 minutes/day), up to 23 days
Closest Location: Johns Hopkins University School of Medicine · Baltimore, MD
Photo of Baltimore 1Photo of Baltimore 2Photo of Baltimore 3
2001First Recorded Clinical Trial
0 TrialsResearching Hypermetria
154 CompletedClinical Trials

Who is running the clinical trial?

Virginia Polytechnic Institute and State UniversityOTHER
108 Previous Clinical Trials
25,504 Total Patients Enrolled
Johns Hopkins UniversityLead Sponsor
2,033 Previous Clinical Trials
30,782,345 Total Patients Enrolled
Johns Hopkins Discovery AwardUNKNOWN
Cherie Marvel, PhDPrincipal InvestigatorJohns Hopkins University
1 Previous Clinical Trials
30 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 3 Total Inclusion Criteria

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About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.