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Fatty Acid
Coconut Oil for Asthma
N/A
Waitlist Available
Led By Elliot Israel, MD
Research Sponsored by Brigham and Women's Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Never smokers or <10 pack year smoking history
Clinical history consistent with asthma for >1 year
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 weeks
Awards & highlights
Study Summary
This trialwill test if coconut oil can increase cholecystokinin & receptor expression in lean asthmatics & whether this correlates with changes in airway stiffness & symptom control.
Who is the study for?
This trial is for lean adults aged 18+ with mild asthma who haven't smoked much (or at all) and don't use inhaled steroids. They should be able to do certain lung function tests and show improvement after using a bronchodilator. Pregnant individuals, recent fatty acid supplement users, or those with major health issues can't participate.Check my eligibility
What is being tested?
The study is testing if adding coconut oil to the diet affects airway muscle stiffness and asthma symptoms by changing certain proteins in the muscles. Participants will eat coconut oil daily for 3 weeks, undergo lung tests, biopsies before and after intake, and answer symptom questionnaires.See study design
What are the potential side effects?
Potential side effects are not detailed but may include discomfort from consuming extra fat like stomach upset or changes in bowel habits. The bronchoscopy procedure could cause throat irritation, coughing, or infection risks.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I have never smoked or have smoked less than 10 pack-years.
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I have had asthma for more than a year.
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My lung function improves significantly after using an albuterol inhaler.
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I haven't used inhaled corticosteroids in the last 3 months.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 3 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 weeks
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Change in Airway Smooth Muscle (ASM) Cholecystokinin (CCK) and Cholecystokinin Receptor (CCK-AR) expression with coconut oil supplementation
Secondary outcome measures
Change in ASM CCK and CCK-AR expression with coconut oil supplementation, versus change in Asthma Control Questionnaire (ACQ) score.
Coconut oil
Coconut oil
+1 moreOther outcome measures
Change in ASM CCK and CCK-AR expression with coconut oil supplementation, versus change in Forced Expiratory Volume in 1 second (FEV1).
Change in ASM CCK and CCK-AR expression with coconut oil supplementation, versus change in peak flow.
Trial Design
1Treatment groups
Experimental Treatment
Group I: coconut oilExperimental Treatment1 Intervention
Subjects will be instructed to supplement their diet with 3 tablespoons of coconut oil daily for three weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
coconut oil
2011
N/A
~100
Find a Location
Who is running the clinical trial?
Brigham and Women's HospitalLead Sponsor
1,608 Previous Clinical Trials
11,469,857 Total Patients Enrolled
41 Trials studying Asthma
215,956 Patients Enrolled for Asthma
Harvard School of Public Health (HSPH)OTHER
272 Previous Clinical Trials
16,304,992 Total Patients Enrolled
5 Trials studying Asthma
2,853,854 Patients Enrolled for Asthma
Elliot Israel, MDPrincipal InvestigatorAsthma Research Center
14 Previous Clinical Trials
5,069 Total Patients Enrolled
14 Trials studying Asthma
5,069 Patients Enrolled for Asthma
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Eligibility Criteria:
This trial includes the following eligibility criteria:- My asthma doesn't improve with 4 puffs of albuterol.I cannot undergo bronchoscopy due to health risks or conditions.You can do a breathing test in a way that meets specific guidelines.You have a body mass index (BMI) of less than 25.Your lung function test shows that you can breathe out at least 60% of the air in one second.I have never smoked or have smoked less than 10 pack-years.I have had asthma for more than a year.My lung function improves significantly after using an albuterol inhaler.I have smoked within the last year or have a history of heavy smoking.I have used inhaled corticosteroids in the last 3 months.You weigh more than what is considered healthy for your height.You have taken fatty acid supplements in the past 3 months.I do not have major health issues other than asthma.I haven't used inhaled corticosteroids in the last 3 months.I am 18 years old or older.
Research Study Groups:
This trial has the following groups:- Group 1: coconut oil
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there any unfilled positions for participants in this experiment?
"Clinicaltrials.gov reveals this medical trial, which was posted on October 1st 2023, is no longer actively recruiting patients. Nevertheless, there are still 322 other clinical studies enrolling participants at the moment."
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