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Nadolol for Asthma
Study Summary
This trial will test if nadolol, a drug that blocks adrenaline, can help improve mild asthma by reducing airway hyperresponsiveness.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2015 Phase 2 trial • 155 Patients • NCT01825122Trial Design
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Who is running the clinical trial?
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- You are currently getting allergy shots.Your lung function is too sensitive to a test called methacholine challenge.Your blood pressure is higher than 110/65mm Hg before starting the trial.Your resting heart rate is at least 60 beats per minute.I have been intubated for asthma in the past.I am currently taking beta-blocker medication.I have diabetes or an overactive thyroid.Your asthma is not well controlled, based on a specific questionnaire score.Your blood tests must be mostly normal, but it's okay if your red blood cell count is at least 30%, platelet count is over 100,000, and liver enzyme levels are not too high.I do not have any health conditions that could affect my study participation or increase risk.I do not have uncontrolled high blood pressure or serious heart conditions.I was hospitalized for asthma in the last year.I have been diagnosed with COPD.I haven't taken any medication that is not allowed in the study recently.I am between 18 and 60 years old with doctor-diagnosed asthma.I have never smoked or I quit smoking over a year ago and smoked less than 10 pack-years.I am not pregnant, not breastfeeding, and will use birth control during the study.I cannot swallow pills.You are allergic to atropine or ipratropium bromide.You have had a bad reaction or allergy to any medication that is a beta-blocker.Your lung function (FEV1) is at least 80% of what is expected for someone your age and size before using a bronchodilator.You are currently struggling with alcoholism or drug abuse.I use my rescue inhaler more than twice a week, not counting before exercise.I haven't needed steroids for a respiratory issue or asthma in the last 6 weeks.I do not have bleeding disorders and my blood clotting tests are within normal range.
- Group 1: Active, nadolol
- Group 2: Placebo
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Approved for 5 Other Conditions - This treatment demonstrated efficacy for 5 other conditions.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What is the aggregate participant count of this research endeavor?
"Unfortunately, this clinical trial is no longer accepting patients. Initially posted on March 1st 2013 and updated August 5th 2016, it has been retired from the list of active research studies. However, if you are still seeking medical trials for asthma, 318 options remain open to you and 3 studies exist that require Nadolol participants."
Does this research endeavor accept participants over a quarter-century of age?
"According to the requirements of this clinical trial, only individuals aged 18 through 60 are eligible for participation. There are 112 trials specifically targeting those younger than 18 years old and 200 applicable to senior citizens over 65."
Are there other precedent studies that have assessed the efficacy of Nadolol?
"Presently, there are 3 ongoing investigations into the effects of Nadolol and none have entered Phase 3. Notably, Houston has a number of research sites conducting trials with 5 in total."
What is the most common application of Nadolol?
"Nadolol has proven to be a successful medication for treating migraine, but it can also offer relief from other medical issues, such as atrial fibrillation, gastroesophageal variceal hemorrhage prophylaxis and thyrotoxicosis."
Are there any specific prerequisites for being eligible to join this clinical trial?
"This medical trial is seeking 60 participants aged 18 to 60 years old who have been diagnosed with asthma. To be considered, applicants must satisfy the following criteria: demonstrate a negative pregnancy test (for females of childbearing age), register an Asthma Control Questionnaire Score of less than 1.25, maintain a pulse rate of at least sixty beats per minute, not smoked for more than one year and had no history smoking exceeding ten pack-years as well as being willing to record daily diary entries and comply with protocol procedures throughout the study's duration."
Is this a pioneering clinical trial?
"Since 2013, there has been an increasing body of research into nadolol. After the first trial involving 60 patients and funded by Invion, Inc., it was greenlit to move onto its Phase 2 drug approval process. Currently 3 studies are being conducted across 4 cities in 1 country."
Does Nadolol present any potent hazards to users?
"After assessing the clinical data, our team has assigned Nadolol a safety rating of 2. This Phase 2 trial provides evidence that this medication is safe to use in humans but there are no studies yet confirming its efficacy."
Is this medical trial currently recruiting participants?
"According to the information published on clinicaltrials.gov, this research is not actively recruiting patients; it was first posted in March of 2013 and last updated in August 2016. Nevertheless, there are currently 321 other trials searching for enrollees at present."
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