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Local Anesthetic

Active Comparator for Rib Fractures

Phase 4

Waitlist Available

Research Sponsored by Stanford University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline and 1, 10, 13, 16, and 17 hours post-lidocaine infusion

Awards & highlights

Study Summary

This trial will test whether IV lidocaine infusion is better than a placebo at reducing pain for people with acute, traumatic rib fractures.

Eligible Conditions

Rib Fractures

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline and 1, 10, 13, 16, and 17 hours post-lidocaine infusion

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline and 1, 10, 13, 16, and 17 hours post-lidocaine infusion

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and 1, 10, 13, 16, and 17 hours post-lidocaine infusion for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Cumulative Oral Morphine Milligram Equivalent (OME) Consumption at 24 Hours

Secondary outcome measures

Cumulative Oral Morphine Milligram Equivalent (OME) Consumption at 48 Hrs

Incentive Spirometry Volumes

Inflammatory Biomarkers

+4 more

Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: Active ComparatorActive Control1 Intervention

Participants will receive a lidocaine infusion

Group II: Placebo ComparatorPlacebo Group1 Intervention

Participants will receive placebo infusion consisting of normal saline

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Stanford UniversityLead Sponsor

2,386 Previous Clinical Trials

17,334,007 Total Patients Enrolled

5 Trials studying Rib Fractures

349 Patients Enrolled for Rib Fractures

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are recruitment efforts for this experiment still being conducted?

"Affirmative, clinicaltrials.gov corroborates that this medical trial is in the process of recruiting participants. This study was initially posted on February 10th 2020 and most recently updated on January 18th 2022; 160 patients are required to be recruited from one clinic site."

Answered by AI

How many volunteers are contributing to this medical research?

"Affirmative. According to the information catalogued on clinicaltrials.gov, this investigation is actively searching for participants since its initial posting date of February 10th 2020 and latest update on January 18th 2022. 160 volunteers are sought at a single location."

Answered by AI

What ailment is Active Comparator commonly prescribed for?

"Active Comparator is a suitable treatment for individuals suffering from cervical syndrome, minor burns, and those who have undergone transplantation."

Answered by AI

Has Active Comparator been explored in any other medical trials?

"Currently, 118 clinical trials are underway to assess the efficacy of Active Comparator. Of these studies, 31 have reached Phase 3 and most are located in Calgary, Alberta though there is also research being conducted at 1094 other sites worldwide."

Answered by AI

Has Active Comparator been granted sanction by the FDA?

"As this is a Phase 4 trial, and the active comparator has already been approved for clinical use, our team at Power have assigned it a safety score of 3."

Answered by AI

Recent research and studies

InjuryJournal

Risk Factors That Predict Mortality in Patients with Blunt Chest Wall Trauma: A Systematic Review and Meta-analysis

Battle, Ceri E., Hayley Hutchings, and Phillip A. Evans. 2012. “Risk Factors That Predict Mortality in Patients with Blunt Chest Wall Trauma: A Systematic Review and Meta-analysis”. Injury. Elsevier BV. doi:10.1016/j.injury.2011.01.004.

The American Journal of SurgeryJournal

The Contribution of Rib Fractures to Chronic Pain and Disability

Gordy, Stephanie, Loic Fabricant, Bruce Ham, Richard Mullins, and John Mayberry. 2014. “The Contribution of Rib Fractures to Chronic Pain and Disability”. The American Journal of Surgery. Elsevier BV. doi:10.1016/j.amjsurg.2013.12.012.

AnesthesiologyJournal

Local Anesthetics and the Inflammatory Response

Hollmann, Markus W., Marcel E. Durieux, and Dennis M. Fisher. 2000. “Local Anesthetics and the Inflammatory Response”. Anesthesiology. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/00000542-200009000-00038.

SurgeryJournal