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Multimodal Pain Relief for Tibial Plateau Fractures

Phase < 1
Waitlist Available
Led By Justin Haller, MD
Research Sponsored by University of Utah
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients with isolated tibial plateau fractures treated by the investigators
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24-hours post-operative
Awards & highlights

Study Summary

This trial will test if multimodal analgesia (different types of pain relief) is more effective than just one type for treating tibial plateau fractures.

Who is the study for?
This trial is for English or Spanish speakers with isolated tibial plateau fractures treated by the study's investigators. It excludes those allergic to injection medications, with significant head trauma affecting consent ability, and patients with multiple traumatic injuries.Check my eligibility
What is being tested?
The study tests the effectiveness of multimodal analgesia injections versus saline injections in reducing pain after tibial plateau fracture surgery. Effectiveness is measured by lower reported pain scores from patients.See study design
What are the potential side effects?
While specific side effects are not listed, typical reactions might include discomfort at the injection site, potential allergic reactions if unknown allergies exist, and possible systemic effects depending on the drugs used in multimodal analgesia.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have a tibial plateau fracture treated by the study's doctors.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24-hours post-operative
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24-hours post-operative for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Visual Analog Scale (VAS) pain

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Multimodal injectionsExperimental Treatment1 Intervention
Superficial multimodal analgesia composition includes 5mg morphine, 500 micrograms epinephrine, and 4ml normal saline. Deep medial multimodal analgesia composition includes 2.5mg morphine, 40 micrograms clonidine, 15mg ketorolac, and 4ml normal saline.
Group II: Saline injectionPlacebo Group1 Intervention
Saline

Find a Location

Who is running the clinical trial?

University of UtahLead Sponsor
1,099 Previous Clinical Trials
1,778,572 Total Patients Enrolled
2 Trials studying Tibial Plateau Fracture
85 Patients Enrolled for Tibial Plateau Fracture
Justin Haller, MDPrincipal InvestigatorUniversity of Utah Orthopaedics
2 Previous Clinical Trials
260 Total Patients Enrolled

Media Library

Multimodal injections (Other) Clinical Trial Eligibility Overview. Trial Name: NCT05037812 — Phase < 1
Tibial Plateau Fracture Research Study Groups: Saline injection, Multimodal injections
Tibial Plateau Fracture Clinical Trial 2023: Multimodal injections Highlights & Side Effects. Trial Name: NCT05037812 — Phase < 1
Multimodal injections (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05037812 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What demographics are being targeted for this research?

"This trial is searching for around 150 participants that have suffered a fracture and are between 18 and 79 years of age."

Answered by AI

Can post-menopausal women participate in this research?

"Enrolment into this particular study is restricted to those aged 18-79. There are 102 trials for patients younger than 18 and 398 for patients that are older than 65."

Answered by AI

Are there many precedents for this type of medical procedure?

"So far, 139 clinical trials have been completed in order to investigate the efficacy of injections. 31 of these trials are still ongoing. Most of the tests are based in Boston, although there are 298 locations running trials for this treatment."

Answered by AI

What are some common afflictions that people use injections to help mitigate?

"Injections are the most popular form of treatment for unresponsive bradycardia. They can also be used to manage other conditions such as pupil dilation, attention deficit hyperactivity disorder (ADHD), and pheochromocytomas."

Answered by AI

Are new volunteers still being sought for this experiment?

"Currently, this clinical trial is not looking for new participants. The most recent update was on March 14th, 2022 and it was originally posted on March 25th, 2019. However, there are 367 clinical trials for patients with fractures and 139 studies for injections that are still recruiting."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Role of Multimodal Analgesia in Decreasing Perioperative Pain in Tibial Plateau Fractures
Justin Haller 2019. "Role of Multimodal Analgesia in Decreasing Perioperative Pain in Tibial Plateau Fractures". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05037812.
~40 spots leftby Mar 2026
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