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Default Bias for Antibiotic Stewardship (LIBRA Trial)

N/A

Waitlist Available

Led By Charlotte Woods-Hill, MD

Research Sponsored by Children's Hospital of Philadelphia

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up one year

Awards & highlights

LIBRA Trial Summary

This trial aims to compare two different methods for reducing the overuse of blood cultures in pediatric intensive care units. The study will examine if these strategies have any impact on the rate of blood cultures, patient

Who is the study for?

This trial is for male or female clinicians over 18 years old who work in Pediatric Intensive Care Units (PICUs) and have direct patient care roles. It's not open to those who don't speak English or PICU clinicians reporting directly to the investigator.Check my eligibility

What is being tested?

The study compares two strategies: a checklist and targeted messaging, aimed at reducing unnecessary blood culture tests in PICUs. It explores how these strategies affect test rates, patient safety, and evaluates their acceptability and feasibility.See study design

What are the potential side effects?

Since this trial involves non-medical interventions like checklists and messaging rather than drugs or medical procedures, traditional side effects are not applicable. However, there may be indirect impacts on workflow or decision-making processes.

LIBRA Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ one year

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~one year

This trial's timeline: 3 weeks for screening, Varies for treatment, and one year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Acceptability of Intervention Measure (AIM)

Feasibility of Intervention Measure (FIM)

Intervention Appropriateness Measure

+1 more

Secondary outcome measures

Safety Outcomes Post-Intervention

Other outcome measures

Qualitative Interview Data

LIBRA Trial Design

2Treatment groups

Experimental Treatment

Group I: Loss AversionExperimental Treatment2 Interventions

This intervention consists of targeted messaging and education that the primary study team will create and ask the Arm B sites to deliver to the PICU clinicians, which focuses on the importance of diagnostic stewardship and the current evidence for the benefit/low risk nature of the stewardship program to date. Sites in this arm will also receive a checklist to guide blood culture decisions, that clinicians at sites will be asked to consult and complete prior to ordering or not ordering a blood culture.

Group II: Default BiasExperimental Treatment1 Intervention

This intervention consists of a checklist to guide blood culture decisions, that a clinician in a site randomized to Arm A will be asked to consult and complete prior to ordering or not ordering a blood culture; as the relevant clinical scenario occurs.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Checklist

2013

N/A

~4710

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Children's Hospital of PhiladelphiaLead Sponsor

709 Previous Clinical Trials

8,583,087 Total Patients Enrolled

National Heart, Lung, and Blood Institute (NHLBI)NIH

3,841 Previous Clinical Trials

47,814,097 Total Patients Enrolled

Charlotte Woods-Hill, MDPrincipal InvestigatorChildren's Hospital of Philadelphia

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are patients currently able to participate in this ongoing trial?

"You are right. As per the information available on clinicaltrials.gov, this particular study is no longer actively seeking participants. The trial was initially posted on January 1st, 2023 and last updated on December 18th, 2023. However, it's worth mentioning that there are currently nineteen other ongoing clinical trials actively recruiting patients at this time."

Answered by AI

How many sites are involved in the execution of this study?

"At present, there are 8 sites actively enrolling patients for this clinical trial. These sites include Los Angeles, San Francisco, and Wilmington, among others. To minimize travel obligations, it is advisable to choose the clinic closest to your location when participating in this study."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

BrighT STAR LIBRA: Leveraging Implementation Science for Blood Culture Reduction Approaches

2023. "BrighT STAR LIBRA: Leveraging Implementation Science for Blood Culture Reduction Approaches". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06187662.

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