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Antiseptic

ICU Decolonization for Staph Infection

Phase 4
Waitlist Available
Led By Richard Platt, MD, MS
Research Sponsored by Harvard Pilgrim Health Care
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 18-month intervention
Awards & highlights

Study Summary

This trial is testing whether two decolonization regimens are equally effective in preventing ICU infections.

Who is the study for?
This trial is for all adult ICU patients in participating U.S. HCA hospitals, including some rare cases of patients aged 12-18 years. Hospitals with ICUs that have an average stay under 2 days or cannot merge data into a central system are excluded.Check my eligibility
What is being tested?
The study compares two methods to prevent Staph infections in the ICU: Routine Care using mupirocin and chlorhexidine baths versus an Iodophor-based regimen with chlorhexidine baths. Hospitals are randomly chosen to use one method.See study design
What are the potential side effects?
Possible side effects include skin irritation from iodophor or mupirocin, allergic reactions, and possibly resistance to these antiseptics if used frequently over time.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~18-month intervention
This trial's timeline: 3 weeks for screening, Varies for treatment, and 18-month intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of Participants With ICU-attributable Staphylococcus Aureus Clinical Cultures
Secondary outcome measures
Number of Participants With ICU Attributable MRSA Clinical Cultures
Number of Participants With ICU-attributable Bloodstream Infections
Other outcome measures
Mupirocin & Iodophor Resistance in MRSA Isolates

Trial Design

2Treatment groups
Active Control
Group I: Arm 1: Routine Care (Mupirocin/CHG)Active Control1 Intervention
ICU nasal decolonization with mupirocin twice daily for 5 days in the context of chlorhexidine for daily bathing
Group II: Arm 2: Iodophor/CHG DecolonizationActive Control1 Intervention
ICU nasal decolonization with iodophor twice daily for 5 days in the context of chlorhexidine for daily bathing

Find a Location

Who is running the clinical trial?

University of California, IrvineOTHER
542 Previous Clinical Trials
1,568,678 Total Patients Enrolled
Rush UniversityOTHER
40 Previous Clinical Trials
30,695 Total Patients Enrolled
University of Massachusetts, AmherstOTHER
78 Previous Clinical Trials
114,449 Total Patients Enrolled

Media Library

Iodophor/CHG Decolonization (Antiseptic) Clinical Trial Eligibility Overview. Trial Name: NCT03140423 — Phase 4
Staph Infection Research Study Groups: Arm 1: Routine Care (Mupirocin/CHG), Arm 2: Iodophor/CHG Decolonization
Staph Infection Clinical Trial 2023: Iodophor/CHG Decolonization Highlights & Side Effects. Trial Name: NCT03140423 — Phase 4
Iodophor/CHG Decolonization (Antiseptic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03140423 — Phase 4
Staph Infection Patient Testimony for trial: Trial Name: NCT03140423 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Could you provide me with information regarding the North American hospitals conducting this experiment?

"This trial is now recruiting patients from a total of 100 clinical sites. Several cities, such as Miami, Caldwell and Aurora are included in this list to provide the closest possible location for prospective participants to minimize travel conditions."

Answered by AI

Could you please elaborate on the level of security that Arm 2: Iodophor/CHG Decolonization offers individuals?

"Due to the advanced stage of clinical testing, Arm 2: Iodophor/CHG Decolonization has been given a safety rating of 3. This Phase 4 trial confirms that this treatment is accepted and approved by authorities."

Answered by AI

What conditions is Arm 2: Iodophor/CHG Decolonization used to address?

"Arm 2: Iodophor/CHG Decolonization is an effective approach for remedying contagious illnesses, Staphylococcus aureus congestion of the nasal cavity, and bacterial infections."

Answered by AI

Are there any unfilled slots for participants in this research project?

"This research is no longer recruiting participants. It was initially posted on the 1st of May 2017 and last updated on March 15th 2022. In its stead, 7 medical experiments are in search of patients with staphylococcus aureus while 4 other trials require volunteers for Arm 2: Iodophor/CHG Decolonization."

Answered by AI

How many participants are receiving treatment within the parameters of this clinical trial?

"At this time, there are no opportunities to join the trial in question. The registration was posted on May 1st 2017 and edited as recently March 15th 2022. Patients looking for other studies may consider one of the 7 clinical trials now recruiting participants with staphylococcus aureus or among 4 different investigations focusing on Arm 2: Iodophor/CHG Decolonization that require volunteers."

Answered by AI

Could you provide an overview of any other experiments featuring Arm 2: Iodophor/CHG Decolonization?

"Currently, there are 4 clinical trials for Arm 2: Iodophor/CHG Decolonization. None of them have reached Phase 3 yet; however, the majority are situated in Saint Louis while 148 other sites around the world host related studies."

Answered by AI

Who else is applying?

What state do they live in?
Texas
What site did they apply to?
Valley Regional Medical Center
Conroe Regional Medical Center
East Houston Regional Medical Center
What portion of applicants met pre-screening criteria?
Did not meet criteria
How many prior treatments have patients received?
0

Why did patients apply to this trial?

I’m interested in this trial.
PatientReceived no prior treatments
Recent research and studies
clinicaltrials.govStudy
Mupirocin-Iodophor ICU Decolonization Swap Out Trial
Richard Platt 2017. "Mupirocin-Iodophor ICU Decolonization Swap Out Trial". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03140423.
~44630 spots leftby Apr 2025
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