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Nasal Povidone-Iodine for Staph Infection (PAINTS Trial)

Phase 4
Waitlist Available
Led By Marin L Schweizer, PhD
Research Sponsored by Marin L. Schweizer, PhD
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion (up to 3 years)
Awards & highlights

PAINTS Trial Summary

This trial will test whether using nasal povidone-iodine at each hemodialysis session can prevent Staphylococcus aureus infections.

Who is the study for?
This trial is for adult patients who are undergoing outpatient chronic hemodialysis at one of the 16 study centers. It's not for those allergic to iodine, currently battling bacterial infections, under 18, on peritoneal or home hemodialysis, or pregnant women.Check my eligibility
What is being tested?
The trial is testing if applying povidone-iodine ointment in the nose during each dialysis session can prevent Staphylococcus aureus infections. This stepped-wedge cluster randomized trial also assesses how feasible and acceptable this intervention is.See study design
What are the potential side effects?
Potential side effects may include local skin reactions like redness or irritation where the povidone-iodine ointment is applied. Since it's a topical treatment, systemic side effects are less common but could include symptoms related to iodine sensitivity.

PAINTS Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion (up to 3 years)
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion (up to 3 years) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Incidence of Staphylococcus aureus bloodstream infection
Secondary outcome measures
Incidence of Access related bloodstream infection by any pathogen
Incidence of Bloodstream infections by any pathogen
Incidence of Local access site infection
+3 more

PAINTS Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Nasal Povidone-Iodine Decolonization InterventionExperimental Treatment2 Interventions
Intranasal povidone-iodine (3M Skin and Nasal Antiseptic) will be applied to the patients' noses at each hemodialysis session.
Group II: Concurrent ControlActive Control1 Intervention
Standard of Care. This will be usual care at each hemodialysis center.

Find a Location

Who is running the clinical trial?

Marin L. Schweizer, PhDLead Sponsor
Agency for Healthcare Research and Quality (AHRQ)FED
397 Previous Clinical Trials
7,088,187 Total Patients Enrolled
Washington University School of MedicineOTHER
1,928 Previous Clinical Trials
2,296,910 Total Patients Enrolled

Media Library

Povidone-Iodine Topical Ointment Clinical Trial Eligibility Overview. Trial Name: NCT04210505 — Phase 4
Staph Infection Research Study Groups: Nasal Povidone-Iodine Decolonization Intervention, Concurrent Control
Staph Infection Clinical Trial 2023: Povidone-Iodine Topical Ointment Highlights & Side Effects. Trial Name: NCT04210505 — Phase 4
Povidone-Iodine Topical Ointment 2023 Treatment Timeline for Medical Study. Trial Name: NCT04210505 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there a set number of healthcare facilities conducting this investigation?

"Currently, this experiment is recruiting participants at 5 different sites. These include Philadelphia, Atlanta and Chicago alongside other cities in the area. To reduce travel requirements for volunteers, it would be beneficial to choose a nearby location if you wish to take part."

Answered by AI

In what situations is Povidone-Iodine Topical Ointment generally prescribed?

"Povidone-Iodine Topical Ointment is a useful tool for disinfecting the skin, prepping the periocular area and treating various epidermal infections."

Answered by AI

Is there still capacity for participants in this research effort?

"This research project has closed its recruitment window as of May 16th, 2022. Originally posted on September 29th 202, no more applicants are being accepted at this time. For those looking for other opportunities, there are currently 788 clinical trials searching for participants with staphylococcal infections and 10 studies still recruiting patients to use Povidone-Iodine Topical Ointment."

Answered by AI

Can you tell me what the known risks are associated with Povidone-Iodine Topical Ointment?

"After careful consideration, our team at Power assigned a score of 3 to Povidone-Iodine Topical Ointment due to its Phase 4 trial status which indicates the treatment is officially approved."

Answered by AI

Could you provide insight into any other experiments assessing the efficacy of Povidone-Iodine Topical Ointment?

"Povidone-Iodine Topical Ointment was initially subjected to clinical trials in 2017, within the Anaheim Crest Nursing Center. A total of 188 studies have concluded since then and 10 are currently active with a substantial proportion based out of Philadelphia, Pennsylvania."

Answered by AI

How many individuals are participating in the research endeavor?

"At the moment, this clinical trial is not currently accepting new candidates. Initially posted on September 29th 2020 and last updated May 16th 2022, if you are looking for other studies to participate in there are 778 staphylococcal infection trials and 10 Povidone-Iodine Topical Ointment clinical trials actively seeking participants."

Answered by AI
~68 spots leftby Mar 2025