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Staph Infection Eradication Strategies for Staph Infection (SHINE Trial)

Phase 4
Waitlist Available
Led By Stephanie A Fritz, MD, MSCI
Research Sponsored by Washington University School of Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients 18 years of age and younger
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 9 months (collected at baseline, 1 month, 3 months, 6 months, and 9 months).
Awards & highlights

SHINE Trial Summary

This trial will compare different ways of reducing the spread of Staphylococcus aureus bacteria, to see which is most effective in reducing skin and soft tissue infections.

Who is the study for?
The SHINE trial is for kids 18 or younger with a recent skin infection caused by Staphylococcus aureus. They must live within 75 miles of St. Louis Children's Hospital and have parental consent. It excludes those with hospital-acquired infections, certain high-risk conditions, inability to give consent, or without a stable home.Check my eligibility
What is being tested?
This study tests if using Mupirocin ointment, Chlorhexidine washes, and cleaning homes can reduce the spread of S. aureus in households and lower skin infection rates compared to usual care practices.See study design
What are the potential side effects?
Possible side effects include skin irritation from Mupirocin or Chlorhexidine and allergic reactions. Regular household cleaning has no known medical side effects but may cause mild discomfort.

SHINE Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am 18 years old or younger.

SHINE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~9 months (collected at baseline, 1 month, 3 months, 6 months, and 9 months).
This trial's timeline: 3 weeks for screening, Varies for treatment, and 9 months (collected at baseline, 1 month, 3 months, 6 months, and 9 months). for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Secondary outcome measures
Confirmed S. aureus Infection
Incidence of SSTI
Mupirocin resistance
+3 more

SHINE Trial Design

3Treatment groups
Experimental Treatment
Group I: Periodic personal decolonizationExperimental Treatment2 Interventions
All household participants will perform chlorhexidine body washes twice weekly for 3 months and apply mupirocin ointment to the anterior nares twice daily for five consecutive days each month for 3 months.
Group II: Integrated personal/household hygieneExperimental Treatment3 Interventions
Participants in households randomized to this arm will perform the Periodic Personal Decolonization plus the Household Environmental Hygiene, described above in arms 1 and 2.
Group III: Household environmental hygieneExperimental Treatment1 Intervention
In addition to their usual cleaning, households will be asked to perform targeted household hygiene focusing on sources known to harbor S. aureus and serve as reservoirs for transmission.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Mupirocin
2014
Completed Phase 4
~2990
Chlorhexidine
2013
Completed Phase 4
~9050

Find a Location

Who is running the clinical trial?

Washington University School of MedicineLead Sponsor
1,940 Previous Clinical Trials
2,302,560 Total Patients Enrolled
Stephanie A Fritz, MD, MSCIPrincipal InvestigatorWashington University School of Medicine
1 Previous Clinical Trials
474 Total Patients Enrolled

Media Library

Household cleaning Clinical Trial Eligibility Overview. Trial Name: NCT02572791 — Phase 4
MRSA Infection Research Study Groups: Periodic personal decolonization, Household environmental hygiene, Integrated personal/household hygiene
MRSA Infection Clinical Trial 2023: Household cleaning Highlights & Side Effects. Trial Name: NCT02572791 — Phase 4
Household cleaning 2023 Treatment Timeline for Medical Study. Trial Name: NCT02572791 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any adverse effects to using Chlorhexidine?

"There is considerable evidence of Chlorhexidine's safety, thus it was awarded a rating of 3."

Answered by AI

Are there any opportunities to partake in this clinical trial currently?

"According to the listing on clinicaltrials.gov, this medical trial is not enlisting patients at present. Initially posted in October 2015 and last updated July 22nd 2022, it appears that 827 other studies are currently seeking participants."

Answered by AI

How extensive is the cohort participating in this clinical experiment?

"This clinical trial is not currently recruiting. It was initially published on October 1st 2015 and its most recent edit took place on July 22nd 2022. Those looking for alternative trials may find 803 studies actively seeking participants with Methicillin Resistant Staphylococcus Aureus (MRSA) infection, as well as 24 different Chlorhexidine-related investigations in search of patients."

Answered by AI

What other empirical tests have been conducted concerning Chlorhexidine?

"Currently, 24 clinical trials for Chlorhexidine are live with 5 of them in the late-stage Phase 3. These medical studies span a wide region, from Idaho Falls to 231 other locations."

Answered by AI

To what ailments is Chlorhexidine normally prescribed as a solution?

"Chlorhexidine is often used in obstetrics and can additionally be utilized to address antisepsis, disinfection, and sore throats."

Answered by AI

Who else is applying?

What state do they live in?
Hawaii
How old are they?
18 - 65
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Staph Household Intervention for Eradication (SHINE)
Stephanie A. Fritz 2015. "Staph Household Intervention for Eradication (SHINE)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02572791.
All > Missouri
~87 spots leftby May 2025
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