Primary Immunodeficiency Clinical Trials
Here are the 6 most popular medical studies for primary immunodeficiency
Alkylating agents
Reduced-Intensity Stem Cell Transplant for Non-Malignant Disorders
This trial is testing whether a reduced-intensity conditioning regimen followed by umbilical cord blood transplant, double cord blood transplant, matched unrelated donor bone marrow transplant, or peripheral blood stem cell transplant is effective in treating patients with non-malignant disorders.
CAR T-cell Therapy
NST Therapy for Chronic Norovirus in Immunocompromised Patients
This trial will test a new therapy for people with a chronic norovirus infection who have either had a stem cell transplant or who have a primary immunodeficiency disorder.
CAR T-cell Therapy
BK CTL for Viral Infections
This trial will test whether a new treatment for BK virus infection is safe and effective. The treatment involves using a person's own immune cells to target the virus. This trial will enroll children, adolescents, and young adults who have not responded to other treatments or who have primary immunodeficiencies.
Popular filter options for primary immunodeficiency trials
PID Clinical Trials
View 17 PID medical studies.
Immunoglobulin Replacement Therapy
Ascenivâ„¢ for Primary Immune Deficiency
This trial is testing a new medication for children with Primary Immunodeficiency Diseases. The medication will be given intravenously every 21 or 28 days, and children will receive six to seven doses during the study.
Hematopoietic Stem Cell Transplantation
Haploidentical HCT for Primary Immunodeficiency
This trial is testing a new way to do a haploidentical transplant, using TCR alpha beta and CD19 depleted stem cells from a donor. The hope is that this will be a safe and effective way to treat the patient's underlying condition.
Alkylating agents
Reduced Intensity BMT + Cyclophosphamide for Primary Immunodeficiency & Bone Marrow Failure
This trial will study how well a reduced intensity conditioning hematopoietic stem cell transplant (HSCT) and post-transplant cyclophosphamide (PTCy) work in patients with primary immune deficiencies (PID), immune dysregulatory syndromes (IDS), and inherited bone marrow failure syndromes (IBMFS).
Primary Immunodeficiency Clinical Trials With No Placebo
View 22 primary immunodeficiency medical studies that do not have a placebo group.
Behavioural Intervention
Identification of specific markers for Low blood cell count
This trial aims to better understand and find effective treatments for autoimmune cytopenias, which are common in patients with immune system disorders. Current treatments often fail, leading to high costs and health risks. The
Immunoglobulin Replacement Therapy
Ascenivâ„¢ for Primary Immune Deficiency
This trial is testing a new medication for children with Primary Immunodeficiency Diseases. The medication will be given intravenously every 21 or 28 days, and children will receive six to seven doses during the study.
Hematopoietic Stem Cell Transplantation
Haploidentical HCT for Primary Immunodeficiency
This trial is testing a new way to do a haploidentical transplant, using TCR alpha beta and CD19 depleted stem cells from a donor. The hope is that this will be a safe and effective way to treat the patient's underlying condition.
View More Primary Immunodeficiency Trials
See another 6 medical studies focused on primary immunodeficiency.
Frequently Asked Questions
Introduction to primary immunodeficiency
What are the top hospitals conducting primary immunodeficiency research?
Primary immunodeficiency is a condition that affects the body's ability to fight off infections and diseases due to an impaired immune system. In the realm of clinical trials for this complex disorder, several top hospitals are leading the way in research and treatment options. Located in San Francisco, the University of California San Francisco is actively conducting four primary immunodeficiency trials, demonstrating their commitment to advancing knowledge in this field. Similarly dedicated, Johns Hopkins Hospital in Baltimore has also initiated four ongoing clinical trials targeting primary immunodeficiency to uncover innovative approaches for managing this condition. Nationwide Children's Hospital located in Columbus joins these institutions with their notable involvement in four active primary immunodeficiency trials as well. Meanwhile, at Children's Hospital of Pennsylvania situated in Philadelphia and Washington University based out of Saint Louis, both institutes have embarked on similar journeys by offering patients access to four cutting-edge clinical trials focusing on primary immunodeficiency.
The significance lies not only within these numbers but also within the impact they can have on individuals affected by primary immunodeficiency disorders worldwide. By exploring new treatments and interventions through these extensive studies, these hospitals strive towards improving patient outcomes and enhancing quality of life for those living with this challenging medical condition.
Which are the best cities for primary immunodeficiency clinical trials?
Los Angeles, California; Baltimore, Maryland; and Columbus, Ohio are among the top cities for primary immunodeficiency clinical trials. These cities host a significant number of ongoing studies in this field. With 6 active trials each, Los Angeles explores treatments like cytotoxic t-lymphocytes and Newnorm, while Baltimore focuses on PID/IDS and BK CTL therapies. Similarly, Columbus investigates cytotoxic t-lymphocytes and Tabelecleucel interventions. These locations provide opportunities for individuals with primary immunodeficiency to participate in cutting-edge research initiatives that may lead to improved treatment options and outcomes.
Which are the top treatments for primary immunodeficiency being explored in clinical trials?
Primary immunodeficiency, a condition characterized by a weakened immune system, is attracting attention in the realm of clinical trials for potential breakthrough treatments. One such treatment showing promise is CliniMACS. Currently undergoing one active trial and recording its first listing in 2023, this innovative therapy holds significant potential for addressing primary immunodeficiency. As researchers delve deeper into these trials, they strive to unlock new possibilities and offer hope to individuals battling with compromised immune systems.
What are the most recent clinical trials for primary immunodeficiency?
Exciting advancements in the field of primary immunodeficiency research have brought forth a range of recent clinical trials that offer hope for patients. Ascenivâ„¢, a Phase 4 trial, has shown promise as a potential treatment option for individuals with primary immunodeficiency. Similarly, Norovirus-specific T-cell therapy (NST) is being explored in Phase 1 trials, aiming to enhance immune responses against this specific virus in patients with primary immunodeficiency. Newnorm and Tabelecleucel are also promising candidates at different stages of development that hold great potential for improving outcomes among those affected by primary immunodeficiency. The progress made through these clinical trials offers renewed optimism and possibilities for enhanced management and treatment options in the near future.
What primary immunodeficiency clinical trials were recently completed?
Recently conducted clinical trials have made significant strides in advancing our understanding and treatment of primary immunodeficiency disorders. Notably, a pioneering trial sponsored by the National Institute of Allergy and Infectious Diseases focused on investigating Janus Kinase (JAK) inhibitors for the management of immune deficiencies. Another groundbreaking study led by Stanford University explored gene therapy as a potential treatment option for severe combined immunodeficiency (SCID). These recent advancements offer hope to individuals living with primary immunodeficiency and pave the way for more effective therapies in the future.