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Povidone-Iodine for Preventing Staph Infection Before Surgery

Phase 4
Waitlist Available
Research Sponsored by Rutgers, The State University of New Jersey
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 30 days
Awards & highlights

Study Summary

This trial will evaluate if a single-dose of 10% povidone-iodine can reduce nasal carriage of S. aureus/MRSA before surgery.

Who is the study for?
This trial is for community-based patients aged 18-80 with a general health status classified as ASA 1-3, who are scheduled for outpatient surgery lasting between 1 to 6 hours. It's not suitable for those on recent chemotherapy or steroids, antimicrobial therapy, allergic to povidone-iodine, currently infected or immunocompromised, pregnant, or if the surgery prevents access to the nose.Check my eligibility
What is being tested?
The study tests whether a single pre-operative dose of Povidone-Iodine (PI) can effectively reduce nasal carriage of Staphylococcus aureus and MRSA compared to normal saline solution. The goal is to see if PI leads to fewer bacteria in nasal cultures taken around the time of surgery.See study design
What are the potential side effects?
Potential side effects may include local irritation or an allergic reaction in the nose where Povidone-Iodine is applied. Since it's used externally and just before surgery, systemic side effects are unlikely but could involve skin rash if there's an allergy.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 30 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 30 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Total CFU (colony forming units)
Secondary outcome measures
Wound Infection

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: treatmentExperimental Treatment1 Intervention
Application of Povidone-Iodine 10% prior to surgery to Nares
Group II: placeboPlacebo Group1 Intervention
Application of 0.9% Sodium Chloride (NaCl) solution prior to surgery to Nares
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Povidone-Iodine 10%
2005
Completed Phase 4
~2060

Find a Location

Who is running the clinical trial?

Rutgers, The State University of New JerseyLead Sponsor
424 Previous Clinical Trials
63,941 Total Patients Enrolled
Alex Bekker, MD/PhDStudy ChairRutgers University

Media Library

treatment Clinical Trial Eligibility Overview. Trial Name: NCT05529173 — Phase 4
Surgical Site Infection Research Study Groups: treatment, placebo
Surgical Site Infection Clinical Trial 2023: treatment Highlights & Side Effects. Trial Name: NCT05529173 — Phase 4
treatment 2023 Treatment Timeline for Medical Study. Trial Name: NCT05529173 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals above the age of 55 being considered for participation in this trial?

"This study is open to any individual who is 18 years of age or older and below the octogenarian mark."

Answered by AI

Is it possible for me to participate in this medical research study?

"This study requires 170 individuals aged between 18 and 80 who have experienced surgical wound infection. To be eligible, they must also meet the criteria of outpatient surgery lasting at least one hour but not longer than six hours in duration as well being a community-based patient with an American Society of Anesthesiology (ASA) score from 1 to 3."

Answered by AI

Are there any unoccupied positions available in this clinical trial?

"According to clinicaltrials.gov, this research is actively seeking participants; the trial was initially advertised on September 6th 2022 and most recently updated November 9th 2022."

Answered by AI

What potential hazards could patients face with this form of treatment?

"Due to this being a Phase 4 trial, and thus the treatment having been approved by medical regulators, we estimate its safety rating on our scale of 1-3 as 3."

Answered by AI

How many individuals are being recruited for this clinical experiment?

"Indeed, the protocol listed on clinicaltrials.gov attests to this trial's current recruitment status. The initial posting occurred on September 6th 2022 and was most recently modified November 9th 2022. 170 volunteers are necessary from one site alone."

Answered by AI
~77 spots leftby Mar 2025