This trial is evaluating whether Sucrose will improve 2 primary outcomes in patients with Postural Orthostatic Tachycardia Syndrome. Measurement will happen over the course of Baseline, 7 days.
This trial requires 30 total participants across 2 different treatment groups
This trial involves 2 different treatments. Sucrose is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 and have already been tested with other people.
"While the disorder is under-recognized and under-reported, POTS patients were more likely to report symptoms such as fatigue and dizziness, rather than nausea and shortness of breath." - Anonymous Online Contributor
"Approximately 50000 new patients are diagnosed with POTS in the United States annually. Many patients will be diagnosed with a comorbid problem, although an accurate diagnosis remains elusive." - Anonymous Online Contributor
"The most commonly used treatment of POTS is the alpha-blocker atenolol. The other commonly used treatments for POTS have not been studied in depth. New treatments that may work in the future might include clonidine, riluzole, gabapentin, and amitriptyline." - Anonymous Online Contributor
"POTS is a disorder classified by the sympathetic system. The symptoms can be divided into three categories namely central postural orthostatic tachycardia syndrome, autonomic failure, and POTS. POTS can be classified by the cause namely vasovagal reflex and neurological factors. The autonomic failure of POTS leads to autonomic dysfunction where cardiovascular changes and decreased blood pressure occur in the absence of orthostatic stress. Clinical features of POTS can be divided into central POTS, parasympathetic POTS, and autonomic POTS. The autonomic failure of POTS occurs in the absence of orthostatic stress on the autonomic system." - Anonymous Online Contributor
"The POTS spectrum includes a spectrum of conditions of unknown cause that range in severity from asymptomatic to severe. The majority of patients with POTS are asymptomatic. The diagnosis can be made on the basis of typical findings and response to treatment." - Anonymous Online Contributor
"Many patients with postural orthostatic tachycardia syndrome can be cured. One group of patients must be selected according to an age >65 years and be tested to exclude a hypervascular POTS-like syndrome." - Anonymous Online Contributor
"POTS is a complex disorder for which there are many known causes. There is a definite relation between POTS and many other neurological conditions including diabetes, Parkinson's, and the common cold. Many POTS patients have syncope symptoms and other tinnitus. A detailed medical history and examination is essential to make the correct diagnosis. A lumbar puncture may be useful to exclude an alternative, and more serious neurological disorder. The most common form of treatment consists of medication, exercise, and lifestyle changes. Other treatments may include deep brain stimulation in a few instances of refractory POTS. There still remains a great deal of research to be done before POTS can be understood fully." - Anonymous Online Contributor
"Sucrose is well tolerated by the majority of patients. The most common side effects reported from studies of sucrose are headache, nausea, vomiting, dizziness, and hypotension. Sucrose-induced nausea and vomiting appears to be caused at least in part by sucrose's prokinetic action at the gastrointestinal tract and in its interaction with cannabinoid receptors. The hypotension effect of sucrose may be a manifestation of its prokinetic activity but may also be related to the hyperinsulinemia. More importantly, sucrose inhibits intestinal absorption of proteins, vitamins, lipids, and electrolytes and may cause gastrointestinal dysfunction." - Anonymous Online Contributor
"Patients with POTS are usually misdiagnosed as having low blood sugar, low blood pressure or heart attacks, although they may have autonomic nervous system problems. Some of these are related to the use of sympathomimetic drugs. Doctors who think they are helping patients with POTS often think the same thing. Therefore, patients often do not get better, and some might get worse. A trial of sucrose for several weeks followed by carefully timed blood sugar monitoring should first rule out low blood sugar and low blood pressure and also check for sympathetic nervous system symptoms. Many people with POTS have overactive or underactive parasympathetic nervous system. This can be diagnosed by a doctor who feels you are not comfortable enough in your clothes." - Anonymous Online Contributor
"If you were to ask an elderly man if he knew what sucrose is, he would say he had no idea. He would only be able to remember the word, sucrose. Because of this lack of knowledge of what the word, sucrose, actually is, he will be confused about what sucrose does or does not contain. Sucrose is a sweetener found in foods, beverages and chewing gum. Sucrose is an artificial sweetener, a food additive and it is also a form of energy (Energy). This article is to help you with the everyday needs that involve a food that is, sucrose. And to provide information that will help you to make important, and easy choices when it comes to eating." - Anonymous Online Contributor
"Individuals with POTS or orthostatic intolerance taking sucrose are at significantly higher risk for adverse effects such as vasovagal syncope, dizziness, and headaches. Sucrose use in this group is therefore contraindicated." - Anonymous Online Contributor
"The use of small doses of sucrose has demonstrated the advantages of improving symptoms in patients with [hypoetesmia secondary to postural orthostatic tachycardia syndrome (POTS)] (COPD). In the future, an increase in treatment duration in patients with [hypoetesmia secondary to postural orthostatic tachycardia syndrome] (POTS) should be taken into consideration in order to improve the symptomatic effect." - Anonymous Online Contributor