Sucrose for Postural Orthostatic Tachycardia Syndrome

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Mayo Clinic in Rochester, Rochester, MN
Postural Orthostatic Tachycardia Syndrome+4 More
Sucrose - Drug
Eligibility
Any Age
All Sexes
What conditions do you have?
Select

Study Summary

This study is evaluating whether intravenous iron sucrose will improve symptoms and cardiovascular indices in patients with postural orthostatic tachycardia syndrome.

See full description

Eligible Conditions

  • Postural Orthostatic Tachycardia Syndrome
  • Iron-deficiency

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Postural Orthostatic Tachycardia Syndrome

Study Objectives

This trial is evaluating whether Sucrose will improve 2 primary outcomes in patients with Postural Orthostatic Tachycardia Syndrome. Measurement will happen over the course of Baseline, 7 days.

Baseline, 7 days
Change in postural heart rate increase
Month 6
Change in autonomic dysfunction symptoms

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Other trials for Postural Orthostatic Tachycardia Syndrome

Trial Design

2 Treatment Groups

Iron Sucrose Group
1 of 2
Placebo Group
1 of 2
Experimental Treatment
Non-Treatment Group

This trial requires 30 total participants across 2 different treatment groups

This trial involves 2 different treatments. Sucrose is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 and have already been tested with other people.

Iron Sucrose GroupSubjects will receive intravenous iron sucrose during a tilt table test
Placebo GroupSubjects will receive intravenous placebo during a tilt table test
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Iron sucrose
FDA approved

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, 7 days, 6 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly baseline, 7 days, 6 months for reporting.

Who is running the study

Principal Investigator
K. S.
Kamal Shouman, Principal Investigator
Mayo Clinic

Closest Location

Mayo Clinic in Rochester - Rochester, MN

Eligibility Criteria

This trial is for patients born any sex of any age. There are 5 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Patients (age 12 to years and older) with chronic (>3 months) symptoms of orthostatic intolerance, including but not limited to lightheadedness, syncope, headache, fatigue, weakness, sweating, nausea and heart palpitations.
Symptomatic orthostatic heart rate increment ≥30 bpm if >19 years old or ≥40 bpm if <19 years old during a 10 minute 70 degree head up tilt study
Presence of non-anemic iron deficiency, defined as serum ferritin levels <20 ug/L with hemoglobin no less than 1 gm/dL below the normal reference range as defined for age and gender
Consent obtained from responsible guardian AND from subjects, 12-17 years of age
Consent obtained for subjects 18 years of age and older

Patient Q&A Section

What is the average age someone gets postural orthostatic tachycardia syndrome?

"While the disorder is under-recognized and under-reported, POTS patients were more likely to report symptoms such as fatigue and dizziness, rather than nausea and shortness of breath." - Anonymous Online Contributor

Unverified Answer

How many people get postural orthostatic tachycardia syndrome a year in the United States?

"Approximately 50000 new patients are diagnosed with POTS in the United States annually. Many patients will be diagnosed with a comorbid problem, although an accurate diagnosis remains elusive." - Anonymous Online Contributor

Unverified Answer

What are common treatments for postural orthostatic tachycardia syndrome?

"The most commonly used treatment of POTS is the alpha-blocker atenolol. The other commonly used treatments for POTS have not been studied in depth. New treatments that may work in the future might include clonidine, riluzole, gabapentin, and amitriptyline." - Anonymous Online Contributor

Unverified Answer

What are the signs of postural orthostatic tachycardia syndrome?

"POTS is a disorder classified by the sympathetic system. The symptoms can be divided into three categories namely central postural orthostatic tachycardia syndrome, autonomic failure, and POTS. POTS can be classified by the cause namely vasovagal reflex and neurological factors. The autonomic failure of POTS leads to autonomic dysfunction where cardiovascular changes and decreased blood pressure occur in the absence of orthostatic stress. Clinical features of POTS can be divided into central POTS, parasympathetic POTS, and autonomic POTS. The autonomic failure of POTS occurs in the absence of orthostatic stress on the autonomic system." - Anonymous Online Contributor

Unverified Answer

What is postural orthostatic tachycardia syndrome?

"The POTS spectrum includes a spectrum of conditions of unknown cause that range in severity from asymptomatic to severe. The majority of patients with POTS are asymptomatic. The diagnosis can be made on the basis of typical findings and response to treatment." - Anonymous Online Contributor

Unverified Answer

Can postural orthostatic tachycardia syndrome be cured?

"Many patients with postural orthostatic tachycardia syndrome can be cured. One group of patients must be selected according to an age >65 years and be tested to exclude a hypervascular POTS-like syndrome." - Anonymous Online Contributor

Unverified Answer

What causes postural orthostatic tachycardia syndrome?

"POTS is a complex disorder for which there are many known causes. There is a definite relation between POTS and many other neurological conditions including diabetes, Parkinson's, and the common cold. Many POTS patients have syncope symptoms and other tinnitus. A detailed medical history and examination is essential to make the correct diagnosis. A lumbar puncture may be useful to exclude an alternative, and more serious neurological disorder. The most common form of treatment consists of medication, exercise, and lifestyle changes. Other treatments may include deep brain stimulation in a few instances of refractory POTS. There still remains a great deal of research to be done before POTS can be understood fully." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of sucrose?

"Sucrose is well tolerated by the majority of patients. The most common side effects reported from studies of sucrose are headache, nausea, vomiting, dizziness, and hypotension. Sucrose-induced nausea and vomiting appears to be caused at least in part by sucrose's prokinetic action at the gastrointestinal tract and in its interaction with cannabinoid receptors. The hypotension effect of sucrose may be a manifestation of its prokinetic activity but may also be related to the hyperinsulinemia. More importantly, sucrose inhibits intestinal absorption of proteins, vitamins, lipids, and electrolytes and may cause gastrointestinal dysfunction." - Anonymous Online Contributor

Unverified Answer

What does sucrose usually treat?

"Patients with POTS are usually misdiagnosed as having low blood sugar, low blood pressure or heart attacks, although they may have autonomic nervous system problems. Some of these are related to the use of sympathomimetic drugs. Doctors who think they are helping patients with POTS often think the same thing. Therefore, patients often do not get better, and some might get worse. A trial of sucrose for several weeks followed by carefully timed blood sugar monitoring should first rule out low blood sugar and low blood pressure and also check for sympathetic nervous system symptoms. Many people with POTS have overactive or underactive parasympathetic nervous system. This can be diagnosed by a doctor who feels you are not comfortable enough in your clothes." - Anonymous Online Contributor

Unverified Answer

What is sucrose?

"If you were to ask an elderly man if he knew what sucrose is, he would say he had no idea. He would only be able to remember the word, sucrose. Because of this lack of knowledge of what the word, sucrose, actually is, he will be confused about what sucrose does or does not contain. Sucrose is a sweetener found in foods, beverages and chewing gum. Sucrose is an artificial sweetener, a food additive and it is also a form of energy (Energy). This article is to help you with the everyday needs that involve a food that is, sucrose. And to provide information that will help you to make important, and easy choices when it comes to eating." - Anonymous Online Contributor

Unverified Answer

Is sucrose typically used in combination with any other treatments?

"Individuals with POTS or orthostatic intolerance taking sucrose are at significantly higher risk for adverse effects such as vasovagal syncope, dizziness, and headaches. Sucrose use in this group is therefore contraindicated." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in sucrose for therapeutic use?

"The use of small doses of sucrose has demonstrated the advantages of improving symptoms in patients with [hypoetesmia secondary to postural orthostatic tachycardia syndrome (POTS)] (COPD). In the future, an increase in treatment duration in patients with [hypoetesmia secondary to postural orthostatic tachycardia syndrome] (POTS) should be taken into consideration in order to improve the symptomatic effect." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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