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Looming task for Postural Orthostatic Tachycardia Syndrome

N/A

Recruiting

Led By Gisela Chelimsky, M.D.

Research Sponsored by Virginia Commonwealth University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Females 12-21 years old

Diagnosed with POTS (POTS will be defined standardly as a symptomatic ≥ 40 bpm rise in heart rate without a drop in blood pressure and with symptoms of orthostatic intolerance clinically)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 90 minutes

Awards & highlights

Study Summary

This trial looks at how people with POTS interpret visual info & how the brain communicates, to help doctors understand the condition better.

Who is the study for?

This trial is for females aged 12-21 with Postural Tachycardia Syndrome (POTS), who can communicate in English and give consent. Healthy girls without POTS or neurological disorders are also needed as controls. Participants should not be using certain hormones, have substance abuse issues, inflammatory/auto-immune diseases, unstable medical conditions like severe kidney/liver disease, uncontrolled psychiatric illnesses, or recent involvement in other drug/device trials.Check my eligibility

What is being tested?

The study tests how young women with POTS process visual information ('Looming task') to understand brain communication patterns. It aims to shed light on the condition's natural history and associated problems by comparing their responses to those of healthy individuals.See study design

What are the potential side effects?

Since this trial involves a non-invasive 'Looming task' which assesses perception rather than medication or invasive procedures, there are no direct side effects related to drugs or surgical interventions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am a female between the ages of 12 and 21.

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I have been diagnosed with POTS, experiencing a significant heart rate increase when standing.

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I am healthy without POTS or neurological disorders.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 90 minutes

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~90 minutes

This trial's timeline: 3 weeks for screening, Varies for treatment, and 90 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Periaqueductal gray region activation - looming task

Central gray substance of midbrain

Trial Design

2Treatment groups

Experimental Treatment

Group I: Adolescents without POTSExperimental Treatment1 Intervention

Group II: Adolescents with POTSExperimental Treatment1 Intervention

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

Virginia Commonwealth UniversityLead Sponsor

699 Previous Clinical Trials

22,885,009 Total Patients Enrolled

1 Trials studying Postural Orthostatic Tachycardia Syndrome

12 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome

Gisela Chelimsky, M.D.Principal InvestigatorVirginia Commonwealth University

Media Library

Adolescents with POTS Clinical Trial Eligibility Overview. Trial Name: NCT05618054 — N/A

Postural Orthostatic Tachycardia Syndrome Research Study Groups: Adolescents with POTS, Adolescents without POTS

Postural Orthostatic Tachycardia Syndrome Clinical Trial 2023: Adolescents with POTS Highlights & Side Effects. Trial Name: NCT05618054 — N/A

Adolescents with POTS 2023 Treatment Timeline for Medical Study. Trial Name: NCT05618054 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research protocol suitable for geriatric participants?

"The aim of this trial is to enrol minors aged between 12 and 18 years old."

Answered by AI

Are additional participants being welcomed into this experiment?

"According to clinicaltrials.gov, this investigational trial is presently enrolling patients. The initial posting of the research was on December 1st 2022 and there have been subsequent updates as recently November 9th 2022."

Answered by AI

What is the current patient population enrolled in this research project?

"Confirmed. Clinicaltrials.gov provides evidence that recruitment is currently underway for this medical trial, originally posted on December 1st 2022 and updated recently in November of the same year. A total of 36 individuals are required to be enrolled at a single site."

Answered by AI

Am I eligible to take part in this clinical experiment?

"This clinical investigation is looking for 36 adolescents between the ages of 12 and 18 with a history of marijuana abuse. All applicants must be female, able to understand/agree to consent forms in English, have POTS (defined as an increase in heart rate without changes in blood pressure during tilt table exam plus symptoms), right-handed, and age-matched healthy controls who do not have neurological issues."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Natural History With Its Numerous Co-morbidities?

2023. "Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Natural History With Its Numerous Co-morbidities?". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05618054.