Impact of Cyanoacrylate Glue on PICC Line Dressing Care

Overseen By Marianne Garland, MD

Age: < 18

Sex: Any

Trial Phase: Academic

Sponsor: Columbia University

Disqualifiers: Outside PICC line, Silicon catheter, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 12 weeks

32 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests if using medical glue at the spot where a tube is inserted into a baby's vein can help keep the bandage in place longer and prevent the tube from moving. It focuses on newborns in NICU who have delicate skin and tend to move a lot. The glue acts like a strong adhesive, making the bandage stick better and last longer.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

Is cyanoacrylate glue safe for use in humans?

Cyanoacrylate glue has been associated with allergic reactions and skin irritation, especially in environments with low humidity. Additionally, its vapors may have mutagenic effects (can cause genetic mutations) and could pose a cancer risk, particularly in industrial settings. ^{1 2 3 4 5}

How does cyanoacrylate adhesive differ from other treatments for bone repair?

Cyanoacrylate adhesive is unique because it forms a strong bond quickly and can be used as a temporary solution in bone repair, but it may cause inflammation and damage to bone tissue over time. Unlike ideal bone adhesives, it does not promote bone cell activity and can be toxic, making it less suitable for long-term use. ^{6 7 8 9 10}

What data supports the effectiveness of the treatment Cyanoacrylate glue?

Research shows that cyanoacrylate glue is effective in reducing infection rates after surgery, such as heart surgery, by sealing wounds better than traditional methods. It also helps in faster recovery, reducing hospital stay, and is successful in treating complications like sternal detachment. ^{11 12 13 14 15}

Who Is on the Research Team?

Marianne Garland, MD

Principal Investigator

Morgan Stanley Children's Hospital of NYP

Are You a Good Fit for This Trial?

Inclusion Criteria

All patients admitted to the 9 North intensive coronary care unit (ICCU) at NewYork-Presbyterian Morgan Stanley Children's Hospital greater than 35 weeks of corrected gestational age who have a PICC line placed by a NICU provider.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants are randomly assigned to either the cyanoacrylate glue group or the control group, and receive PICC line dressing care according to their group assignment.

12 weeks

Regular visits for dressing changes and monitoring

Follow-up

Participants are monitored for safety and effectiveness after treatment, focusing on PICC line migration and dressing longevity.

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Cyanoacrylate glue

How Is the Trial Designed?

Group I: Cyanoacrylate Glue Group Experimental Treatment 2 Interventions

This group will receive a few drops of cyanoacrylate glue on PICC line site prior to application of usual standard film dressing over the PICC line site.

Group II: Control Group Active Control 1 Intervention

This group will be received the current standard of care (SOC) dressing method for PICC lines.

Who Is Running the Clinical Trial?

Columbia University

Lead Sponsor

Trials

1,529

Recruited

2,832,000+

Citations

1. England pubmed.ncbi.nlm.nih.gov

Prevention of knot slippage with the use of cyanoacrylate glue: a mechanical study. [2019]

2. England pubmed.ncbi.nlm.nih.gov

Is skin closure with cyanoacrylate glue effective for the prevention of sternal wound infections? [2016]

3. India pubmed.ncbi.nlm.nih.gov

Evaluation of isoamyl 2-cyanoacrylate tissue adhesive in management of pediatric lacerations: An alternative to suturing. [2022]

4. England pubmed.ncbi.nlm.nih.gov

Outcomes of N-butyl-2-Cyanoacrylate Tissue Adhesive Application in Corneal Perforation Disorders: Consecutive Case Series. [2023]

5. India pubmed.ncbi.nlm.nih.gov

A comparative study: efficacy of tissue glue and sutures after impacted mandibular third molar removal. [2021]

6. United States pubmed.ncbi.nlm.nih.gov

Cyanoacrylate glue reactions: A systematic review, cases, and proposed mechanisms. [2023]

7. Netherlands pubmed.ncbi.nlm.nih.gov

Bacterial mutagenicity of some methyl 2-cyanoacrylates and methyl 2-cyano-3-phenylacrylates. [2019]

8. Netherlands pubmed.ncbi.nlm.nih.gov

Mutagenic action of methyl 2-cyanoacrylate vapor. [2019]

9. United States pubmed.ncbi.nlm.nih.gov

Patch Testing Ingredients of Dermabond and Other Cyanoacrylate-Containing Adhesives. [2020]

10. England pubmed.ncbi.nlm.nih.gov

Cyanoacrylate dermatitis. [2019]

11. United States pubmed.ncbi.nlm.nih.gov

Cyanoacrylate medical adhesives--a new era Colgate ORABASE Soothe.N.Seal Liquid Protectant for canker sore relief. [2016]

12. United States pubmed.ncbi.nlm.nih.gov

N-Butyl-2-cyanoacrylate use in intraoperative ruptured aneurysms as a salvage rescue: case report. [2016]

13. Scotland pubmed.ncbi.nlm.nih.gov

Cyanoacrylate tissue adhesive in osseous repair. [2019]

14. England pubmed.ncbi.nlm.nih.gov

Elasticity and safety of alkoxyethyl cyanoacrylate tissue adhesives. [2021]

15. United States pubmed.ncbi.nlm.nih.gov

Durability of the bond between bone and various 2-cyanoacrylates in an aqueous environment. [2013]