Cyanoacrylate Glue for Newborn Illness
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests whether adding a few drops of cyanoacrylate glue (a type of adhesive) to a PICC line (a type of long-term IV line) can help keep the dressing in place longer and reduce the need for dressing changes. The goal is to determine if using the glue results in fewer dressing changes per week compared to the usual care. It is ideal for patients in the 9 North intensive coronary care unit with a PICC line inserted by the NICU team. As an unphased trial, this study offers patients the opportunity to contribute to innovative care improvements in a real-world setting.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What prior data suggests that applying cyanoacrylate glue to PICC lines is safe?
Research has shown that using cyanoacrylate glue on PICC lines reduces complications compared to not using it. The glue is generally safe and well-tolerated. Some studies have raised concerns about infections called CLABSI (central line-associated bloodstream infections), but these are not directly linked to the glue. The evidence does not indicate any major safety issues with the glue, and it effectively secures PICC lines. This makes it a promising option with no major safety concerns reported so far.12345
Why are researchers excited about this trial?
Researchers are excited about using cyanoacrylate glue for PICC line dressing care because it offers a potentially more effective way to secure the line and reduce infection risk. Unlike the standard of care, which typically involves using traditional film dressings, cyanoacrylate glue creates a strong, protective seal at the insertion site. This glue not only helps keep the line in place but might also act as a barrier against bacteria, potentially lowering the chance of complications. By improving the dressing method, this approach could make PICC lines safer and more reliable for patients.
What evidence suggests that using cyanoacrylate glue is effective for extending PICC dressing duration?
In this trial, participants in the Cyanoacrylate Glue Group will receive a few drops of cyanoacrylate glue on the PICC line site before the standard film dressing is applied. Research has shown that cyanoacrylate glue effectively secures catheters, such as PICC lines. Studies have found that this glue helps prevent infections and stops catheter movement. One study discovered that using this glue reduces the frequency of dressing changes. The glue creates a strong bond at the catheter site, keeping it secure for longer. Overall, evidence suggests that cyanoacrylate glue enhances the stability and cleanliness of PICC lines.12567
Who Is on the Research Team?
Marianne Garland, MD
Principal Investigator
Morgan Stanley Children's Hospital of NYP
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are randomly assigned to either the cyanoacrylate glue group or the control group, and receive PICC line dressing care according to their group assignment.
Follow-up
Participants are monitored for safety and effectiveness after treatment, focusing on PICC line migration and dressing longevity.
What Are the Treatments Tested in This Trial?
Interventions
- Cyanoacrylate glue
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
This group will receive a few drops of cyanoacrylate glue on PICC line site prior to application of usual standard film dressing over the PICC line site.
This group will be received the current standard of care (SOC) dressing method for PICC lines.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Columbia University
Lead Sponsor
Citations
Effectiveness of cyanoacrylate glue in the fixation of midline ...
The objective of the study was to assess the efficacy of the use of cyanoacrylate glue (CAG) as a means of securing midline catheters and peripherally inserted ...
Impact of Cyanoacrylate Glue on PICC Line Dressing Care
covariates (age, sex, diagnosis, catheter size, & PICC insertion site) on the outcome. As per our CLABSI (central line-associated bloodstream infections) ...
3.
aspenjournals.onlinelibrary.wiley.com
aspenjournals.onlinelibrary.wiley.com/doi/full/10.1002/jpen.2583Peripherally inserted central catheter securement with ...
In recent years, cyanoacrylate glue (CG), used to secure and seal catheters, has been reported to be effective in preventing catheter infection ...
Study Comparing the Efficacy of Peripherally Inserted ...
This is a randomized, prospective, single-center trial comparing the efficacy of peripherally inserted central catheter (PICC) with the addition ...
Clinical benefit of adding cyanoacrylate glue during PICC ...
CAG provides an immediate benefit at the end of PICC insertion that lasts for up to 1 h after the end of the procedure. The use of CAG would improve the ...
Effect of tissue adhesive application on central line ...
Among the adverse events, CLABSI can cause serious consequences, with reported rates of 0.33–4.30 per 1000 catheter-days [3,4]. Notably, centrally or femorally ...
Can Peripherally Inserted Central Catheters Be Safely Placed ...
These findings provide clinicians with evidence that peripherally inserted central catheters (PICCs) are safe for chemotherapy administration.
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