Study Summary
This trial is testing whether iohexol can help doctors calculate the dose of carboplatin given to cancer patients.
Treatment Effectiveness
Effectiveness Progress
Study Objectives
5 Primary · 4 Secondary · Reporting Duration: Up to 4 weeks
Trial Safety
Safety Progress
Trial Design
1 Treatment Group
Treatment (iohexol, standard care carboplatin, blood samples)
1 of 1
Experimental Treatment
350 Total Participants · 1 Treatment Group
Primary Treatment: Iohexol · No Placebo Group · Phase 1
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18+ · Male Participants · 7 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Frequently Asked Questions
How many participants are involved in the current clinical trial?
"This clinical trial necessitates 250 eligible participants, and recruiting is taking place in two centres - UPCI located in Pittsburgh, Pennsylvania; and Saint Louis Cancer & Breast Institute-Ballwin in Ballwin, New York." - Anonymous Online Contributor
Are there any precedents of research that have utilized Iohexol?
"Iohexol was initially investigated in 2002 at H Central de Asturias. Since then, 866 studies have been completed with 711 currently active experiments, many of which are conducted out of Pittsburgh, Pennsylvania." - Anonymous Online Contributor
What medical issues can Iohexol aid in alleviating?
"Iohexol is frequently administered to treat non-Hodgkin lymphoma, but it may also be utilized in the management of sarcoma and Hodgkin disease." - Anonymous Online Contributor
What potential hazards do patients face when taking Iohexol?
"Iohexol has been minimally studied, hence it received a score of 1 on our risk assessment scale. This is because this medical trial is in the early stages and lacks sufficient data to ensure safety." - Anonymous Online Contributor
Are there a plentiful number of medical centers conducting this trial in North America?
"This study is being conducted in various locations, including University of Pittsburgh Cancer Institute (UPCI) in Pennsylvania, Saint Louis Cancer and Breast Institute-Ballwin in New York, Memorial Sloan Kettering Cancer Center in Virginia, and a further 100 sites." - Anonymous Online Contributor
Are new participants being enrolled in this research project?
"Clinicaltrials.gov reports that recruitment for this clinical trial is still ongoing, following its initial posting on November 18th 2019 and latest update from August 31st 2022." - Anonymous Online Contributor
What are the main goals of this medical experiment?
"The principal objective of this 4-week clinical trial is to discover the relationship between carboplatin clearance and mGFR. Secondary goals involve measuring the divergence of eGFR from mGFR, ascertaining how accurately target carboplatin AUCs can be reached among patients with elevated eGFR levels, and assessing if pre-treatment serum markers other than creatinine aid in providing an estimate for kidney function for cancer patients." - Anonymous Online Contributor