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Capsaicin, Phenylephrine, Caffeine Combination

CPC - Capsaicin, Phenylephrine, Caffeine for Vasovagal Syncope

Phase 2
Waitlist Available
Led By Mohamed H Hamdan, MD
Research Sponsored by University of Wisconsin, Madison
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Established diagnosis of typical vasovagal syncope or near syncope
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up during tilt table testing (up 35 minutes)
Awards & highlights

Study Summary

This trial will test the effects of a new medication, CPC, on people with a history of fainting spells brought on by sudden changes in position.

Eligible Conditions
  • Vasovagal Syncope

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You have a confirmed diagnosis of vasovagal syncope or near syncope.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~during tilt table testing (up 35 minutes)
This trial's timeline: 3 weeks for screening, Varies for treatment, and during tilt table testing (up 35 minutes) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Percentage of participants who have hypotensive syncope or near syncope with SBP less than or equal to 70 mmHG during tilt test
Secondary outcome measures
Fatigue Score at 1, 4, and 8 hours post tilt table testing
Percentage of patients who have asystolic pauses > 3 sec in the CPC and placebo arms
Time to syncope or near-syncope after CPC or placebo administration

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: CPC AdminstrationExperimental Treatment2 Interventions
Single dose of CPC will be given during tilt table test
Group II: Placebo AdminstrationPlacebo Group2 Interventions
Single dose of Placebo will be given during tilt table test
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Caffeine
FDA approved
Tilt Table Test
2021
Completed Phase 2
~140

Find a Location

Who is running the clinical trial?

University of Wisconsin, MadisonLead Sponsor
1,176 Previous Clinical Trials
3,011,811 Total Patients Enrolled
Mohamed H Hamdan, MDPrincipal InvestigatorUniversity of Wisconsin, Madison

Media Library

CPC (Capsaicin, Phenylephrine, Caffeine Combination) Clinical Trial Eligibility Overview. Trial Name: NCT04972123 — Phase 2
Vasovagal Syncope Research Study Groups: CPC Adminstration, Placebo Adminstration
Vasovagal Syncope Clinical Trial 2023: CPC Highlights & Side Effects. Trial Name: NCT04972123 — Phase 2
CPC (Capsaicin, Phenylephrine, Caffeine Combination) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04972123 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What condition does the medication CPC - Capsaicin, Phenylephrine, Caffeine commonly help?

"The symptoms of eye pain and an enlarged pupil can both be alleviated by using a medication that contains capsaicin, phenylephrine, and caffeine."

Answered by AI

Has the FDA cleared CPC - Capsaicin, Phenylephrine, Caffeine for use?

"CPC - Capsaicin, Phenylephrine, Caffeine - is currently in Phase 2 of clinical trials. While there is evidence that it is safe, more research needs to be done to support its efficacy."

Answered by AI

Would this test be appropriate for somebody who is middle-aged?

"This particular clinical trial has an age range of 18 to 50 for patients who wish to enroll."

Answered by AI

Are there any specific inclusion criteria for subjects of this research?

"This trial is looking for 132 participants who have syncope and are between 18-50 years old."

Answered by AI

Is this research study still open to new participants?

"That is correct, the online information does show that the medical study is still recruiting individuals. The listing was first put up on July 20th, 2021 and was last updated 30 days ago. The researchers conducting the trial need 132 patients total, and are only looking at one potential site."

Answered by AI
~38 spots leftby Mar 2025