Tilt Table Test for Vasovagal Syncope

University of Wisconsin- Madsion, Madison, WI
Vasovagal SyncopeTilt Table Test - DiagnosticTest
18 - 50
All Sexes
What conditions do you have?

Study Summary

This trial will test the effects of a new medication, CPC, on people with a history of fainting spells brought on by sudden changes in position.

Eligible Conditions
  • Vasovagal Syncope

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
Phase 2

Study Objectives

1 Primary · 3 Secondary · Reporting Duration: During tilt table testing (up 35 minutes)

During tilt table testing (up 35 minutes)
Percentage of participants who have hypotensive syncope or near syncope with SBP less than or equal to 70 mmHG during tilt test
Percentage of patients who have asystolic pauses > 3 sec in the CPC and placebo arms
Time to syncope or near-syncope after CPC or placebo administration
Hour 8
Fatigue Score at 1, 4, and 8 hours post tilt table testing

Trial Safety

Phase-Based Safety

2 of 3
This is further along than 68% of similar trials

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 10 Other Conditions
This treatment demonstrated efficacy for 10 other conditions.

Trial Design

2 Treatment Groups

CPC Adminstration
1 of 2
Placebo Adminstration
1 of 2

Experimental Treatment

Non-Treatment Group

132 Total Participants · 2 Treatment Groups

Primary Treatment: Tilt Table Test · Has Placebo Group · Phase 2

CPC AdminstrationExperimental Group · 2 Interventions: Tilt Table Test, CPC - Capsaicin, Phenylephrine, Caffeine · Intervention Types: DiagnosticTest, Drug
Placebo AdminstrationPlaceboComparator Group · 2 Interventions: Tilt Table Test, Placebo · Intervention Types: DiagnosticTest, Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: during tilt table testing (up 35 minutes)

Who is running the clinical trial?

University of Wisconsin, MadisonLead Sponsor
1,101 Previous Clinical Trials
2,900,171 Total Patients Enrolled
Mohamed H Hamdan, MDPrincipal InvestigatorUniversity of Wisconsin, Madison

Eligibility Criteria

Age 18 - 50 · All Participants · 1 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have a confirmed diagnosis of vasovagal syncope or near syncope.

Frequently Asked Questions

What condition does the medication CPC - Capsaicin, Phenylephrine, Caffeine commonly help?

"The symptoms of eye pain and an enlarged pupil can both be alleviated by using a medication that contains capsaicin, phenylephrine, and caffeine." - Anonymous Online Contributor

Unverified Answer

Has the FDA cleared CPC - Capsaicin, Phenylephrine, Caffeine for use?

"CPC - Capsaicin, Phenylephrine, Caffeine - is currently in Phase 2 of clinical trials. While there is evidence that it is safe, more research needs to be done to support its efficacy." - Anonymous Online Contributor

Unverified Answer

Would this test be appropriate for somebody who is middle-aged?

"This particular clinical trial has an age range of 18 to 50 for patients who wish to enroll." - Anonymous Online Contributor

Unverified Answer

Are there any specific inclusion criteria for subjects of this research?

"This trial is looking for 132 participants who have syncope and are between 18-50 years old." - Anonymous Online Contributor

Unverified Answer

Is this research study still open to new participants?

"That is correct, the online information does show that the medical study is still recruiting individuals. The listing was first put up on July 20th, 2021 and was last updated 30 days ago. The researchers conducting the trial need 132 patients total, and are only looking at one potential site." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.