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Alkylating agents

Cyclophosphamide for Blood Cancers

Q: How does Hematopoietic stem cell transplantation help patients suffering from blood disorders?

Hematopoietic stem cell transplantation is a versatile treatment that can be used for <a href="https://www.withpower.com/clinical-trials/lung-cancer">lung cancer</a>, <a href="https://www.withpower.com/clinical-trials/leukemia">leukemia</a>, and other conditions like dermatitis and <a href="https://www.withpower.com/clinical-trials/multiple-sclerosis">multiple sclerosis</a>.

Q: Are there other examples of successful Hematopoietic stem cell transplantation?

Currently, there are 1067 clinical trials studying Hematopoietic stem cell transplantation, with 187 in Phase 3. While several of the trials for Hematopoietic stem cell transplantation are based in Philadelphia, <a href="https://www.withpower.com/clinical-trials/pennsylvania">Pennsylvania</a>, there are 29777 locations running clinical trials for Hematopoietic stem cell transplantation.

Q: Is it possible to join this experiment at this time?

At this time, this particular trial is not recruiting patients. However, according to the latest update on September 14th, 2022, this could change in the future. If you are interested in participating in similar studies, there are 2616 hematologic neoplasms trials and 1067 Hematopoietic stem cell transplantation trials that are actively enrolling participants.

Q: Has the FDA cleared Hematopoietic stem cell transplantation as a treatment option?

Hematopoietic stem cell transplantation is still being studied for safety and efficacy. However, there is some data supporting its safety which gives it a score of 2.

Q: How many individuals have signed up to participate in this clinical trial?

This research is not looking for more participants at the moment. The first posting was on February 10th, 2011 and the most recent update was September 14th, 2022. If you are interested in other studies, 2616 trials for hematologic neoplasms and 1067 trials involving hematopoietic stem cell transplantation are currently admitting patients.

Phase 2

Waitlist Available

Led By John L Wagner, MD

Research Sponsored by Sidney Kimmel Cancer Center at Thomas Jefferson University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 100 days post-transplant

Awards & highlights

Study Summary

This trial is testing whether using cyclophosphamide after a stem cell infusion will increase the chances of the transplant taking, decrease the incidence of graft versus host disease, and improve survival rates.

Eligible Conditions

Blood Cancers

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 100 days post-transplant

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~100 days post-transplant

This trial's timeline: 3 weeks for screening, Varies for treatment, and 100 days post-transplant for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Successful Engraftment Using Cyclophosphamide Post-Transplant

Secondary outcome measures

Incidence of GVHD Unresponsive to Corticosteroids and Photopheresis

Incidence of Grade III-IV GVHD

Transplant-Related Mortality

Trial Design

2Treatment groups

Experimental Treatment

Group I: Reduced Intensity HSCTExperimental Treatment7 Interventions

Reduced Intensity Hematopoietic Stem Cell Transplantation (HSCT): Patients who have received a previous transplant, patients who have received dose limiting radiation, and patients with a DLCO <45% will receive the reduced intensity conditioning regimen.

Group II: Myeloablative HSCTExperimental Treatment5 Interventions

Myeloablative Hematopoietic Stem Cell Transplantation (HSCT): Patients will receive myeloablative transplants or nonmyeloablative transplants depending on their disease type.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Total Body Irradiation

2006

Completed Phase 3

~820

Tacrolimus

2011

Completed Phase 4

~4740

Cyclophosphamide

1995

Completed Phase 3

~3770

Mycophenolate mofetil

2014

Completed Phase 4

~2350

Fludarabine

2012

Completed Phase 3

~1100

Busulfan

2008

Completed Phase 3

~1120

Hematopoietic stem cell transplantation

2008

Completed Phase 2

~430

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Sidney Kimmel Cancer Center at Thomas Jefferson UniversityLead Sponsor

162 Previous Clinical Trials

10,831 Total Patients Enrolled

John L Wagner, MDPrincipal InvestigatorThomas Jefferson University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How does Hematopoietic stem cell transplantation help patients suffering from blood disorders?

"Hematopoietic stem cell transplantation is a versatile treatment that can be used for lung cancer, leukemia, and other conditions like dermatitis and multiple sclerosis."

Answered by AI

Are there other examples of successful Hematopoietic stem cell transplantation?

"Currently, there are 1067 clinical trials studying Hematopoietic stem cell transplantation, with 187 in Phase 3. While several of the trials for Hematopoietic stem cell transplantation are based in Philadelphia, Pennsylvania, there are 29777 locations running clinical trials for Hematopoietic stem cell transplantation."

Answered by AI

Is it possible to join this experiment at this time?

"At this time, this particular trial is not recruiting patients. However, according to the latest update on September 14th, 2022, this could change in the future. If you are interested in participating in similar studies, there are 2616 hematologic neoplasms trials and 1067 Hematopoietic stem cell transplantation trials that are actively enrolling participants."

Answered by AI

Has the FDA cleared Hematopoietic stem cell transplantation as a treatment option?

"Hematopoietic stem cell transplantation is still being studied for safety and efficacy. However, there is some data supporting its safety which gives it a score of 2."

Answered by AI

How many individuals have signed up to participate in this clinical trial?

"This research is not looking for more participants at the moment. The first posting was on February 10th, 2011 and the most recent update was September 14th, 2022. If you are interested in other studies, 2616 trials for hematologic neoplasms and 1067 trials involving hematopoietic stem cell transplantation are currently admitting patients."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

A Research Study of Bone Marrow Transplantation From Unrelated or Partially Matched Related Donors

2011. "A Research Study of Bone Marrow Transplantation From Unrelated or Partially Matched Related Donors". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01349101.