MASTERY for Middle Aged

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Massachusetts General Hospital, Boston, MA
Middle Aged
MASTERY - Behavioral
Eligibility
18 - 65
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a text message intervention can help people with midlife stress.

See full description

Treatment Effectiveness

Study Objectives

This trial is evaluating whether MASTERY will improve 1 primary outcome and 24 secondary outcomes in patients with Middle Aged. Measurement will happen over the course of Weekly over 12 weeks..

6 weeks; 12 weeks
Mean utility ratings of phone check-ins
Mean utility ratings of physical activity text messages
Mean utility ratings of positive psychology text messages
Mean utility ratings of stress reduction text messages
Week 12
Change in Moderate-Vigorous Physical Activity [MVPA]
Change in anxiety (Hospital Anxiety and Depression Scale anxiety subscale [HADS-A])
Change in blood pressure (millimeters of mercury)
Change in body mass index (in kilograms per square meter)
Change in body weight
Change in depressive symptoms (Hospital Anxiety and Depression Scale depression subscale [HADS-D])
Change in exercise self-efficacy (Self-efficacy for Exercise Scale [SES])
Change in function (General Health Questionnaire-12 [GHQ-12])
Change in life satisfaction (Satisfaction with Life Scale [SWLS])
Change in mental health related quality of life (Medical Outcomes Study Short Form-12 mental component score [SF-12 MCS])
Change in optimism (Life Orientation Test - Revised [LOT-R])
Change in overall physical activity
Change in perceived constraints (perceived constraints subscale of the MIDUS Sense of Control measure)
Change in personal mastery (personal mastery subscale of the MIDUS Sense of Control measure)
Change in physical health related quality of life (Medical Outcomes Study Short Form-12 physical component score [SF-12 PCS])
Change in positive affect (positive affect items of the Positive and Negative Affect Schedule [PANAS])
Change in sedentary leisure time
Change in self-reported physical activity
Change in social support (Norbeck Social Support Questionnaire)
Change in waist circumference (in centimeters)
Weekly over 12 weeks.
Proportion of text message sessions completed

Trial Safety

Trial Design

2 Treatment Groups

Attentional control
1 of 2
MASTERY Intervention
1 of 2
Active Control
Experimental Treatment

This trial requires 80 total participants across 2 different treatment groups

This trial involves 2 different treatments. MASTERY is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

MASTERY Intervention
Behavioral
Participants will complete a positive psychology activity, work towards a physical activity goal, and use a stress reduction technique, then will complete weekly text message sessions. In the first six weeks, participants will review the activities they performed the prior week, be introduced to new material, choose activities to perform that week, and set a new physical activity goal during the text message sessions. In the final 6 weeks, participants will review progress towards prior goals, set new physical activity goals, and choose positive psychology and stress reduction skills to use that week. Finally, over the course of the program participants will complete three brief calls with a study trainer to discuss progress.
Attentional control
Behavioral
Participants will receive the same physical activity component noted in MASTERY along with added messages providing education and guidance about physical activity, from our past work. Control participants will not receive PP or midlife-related content.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
MASTERY
2019
N/A
~20

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 6 weeks; 12 weeks
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 6 weeks; 12 weeks for reporting.

Who is running the study

Principal Investigator
J. C. H.
Jeff C. Huffman, MD
Massachusetts General Hospital

Closest Location

Massachusetts General Hospital - Boston, MA

Eligibility Criteria

This trial is for patients born any sex between 18 and 65 years old. There are 2 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Midlife status (age 45-64 at enrollment).
Low baseline physical activity (≤150 minutes/week of MVPA]) as initially self-reported via the well-validated IPAQ and then confirmed via accelerometer after 7 days of wear.

Patient Q&A Section

What are common treatments for middle aged?

"The most common treatment for middle aged patients is physical and occupational therapy, and the majority are managed using primary care. Although the study was limited in terms of breadth and depth from the data collected, it could have been more extensive, which results in gaps in the knowledge base." - Anonymous Online Contributor

Unverified Answer

What are the signs of middle aged?

"In middle aged people with no previous history of smoking, the signs of atherosclerosis are prevalent with at least one third having at least one additional manifestation such as diabetes, hypertension, hyperlipidaemia or stroke." - Anonymous Online Contributor

Unverified Answer

How many people get middle aged a year in the United States?

"For men and women in the United States, the most common age range has a higher prevalence of osteoarthritis compared to men in other age ranges. It may be prudent to be especially mindful of preventive measures in certain age ranges to prevent the development of osteoarthritis in the future." - Anonymous Online Contributor

Unverified Answer

Can middle aged be cured?

"Although men with higher risk disease such as high grade or stage IV disease have the highest mortality, these men can be cured with high cure rates. Men without risk factors should be considered as curable." - Anonymous Online Contributor

Unverified Answer

What causes middle aged?

"The causes of middle aged patients are different from those of younger and older patients. Younger patients tend to experience emotional distress and anxiety, whilst older patients have physical, psychological and/or social concerns. All the patients are at much greater risk of developing chronic disease when disease processes exist as a result of age." - Anonymous Online Contributor

Unverified Answer

What is middle aged?

"In a hospital setting the probability of developing anemia is approximately 1%. It is estimated that approximately 250,000 to 750,000 people with anemia receive some sort of blood transfusion per year in the US, and the likelihood of receiving one is between 2.2 and 3.6%, depending on age and the transfusion center. In the US, there are 5% of the population with moderate anemia. It is estimated that about 6.5 million people are on blood transfusion therapy. In addition to the potential benefits associated with blood transfusions, the financial burden incurred in these procedures may play a role." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of middle aged?

"Primary cause of MALE include acute trauma/trauma mechanism and chronic disorders. For MALE, the pathologic mechanism is not only related to acute trauma but also other organic diseases such as infection, metabolic diseases, vascular disease, etc." - Anonymous Online Contributor

Unverified Answer

How does mastery work?

"Data from a recent study confirms an association between mastery and physical health. It further demonstrates that a positive directionality of the association, i.e., improvement in mental health is more consequential for physical health than the reverse." - Anonymous Online Contributor

Unverified Answer

Who should consider clinical trials for middle aged?

"Age does not dictate whether patients with cancer should pursue clinical trials. The age of 70 years is a common age for enrollment in cancer clinical trials." - Anonymous Online Contributor

Unverified Answer

Is mastery safe for people?

"The findings of this study suggest that mastery is related to safer sex and condom use. However, they also argue that mastery interventions should incorporate more complex skills, as mastery may not be equivalent to safety behaviours without skills training." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets middle aged?

"This article defines middle aged as being from age 36 to age 60 years. Because age varies from person to person, the exact age of midlife for an individual can differ significantly. For example, one study has found that the average age for men in their 60s is 66 years while the average age for women in the same age range is 64.5 years. As one ages, this can have various significant effects including health issues and death. For example, if you are a male in the 55 to 60 years old age range, your life expectancy on average ranges from 65 to 80 years. The life expectancy for women under the same age range is typically around 59 years." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of mastery?

"The common side effects of mastery were consistent with those previously reported in the literature. The present findings support the theoretical perspective that mastery is associated with the appraisal (e.g, positive or negative) of self-efficacy, but not with the appraisal (e.g, positive or negative) of self-efficacy and mastery moderates between-subject self-efficacy in the sense that enhancing mastery was most effective when combined with self-efficacy enhancement." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
See if you qualify for this trial
Get access to this novel treatment for Middle Aged by sharing your contact details with the study coordinator.