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Antimalarial

Hydrocholoroquine Pre-exposure prophylaxis for COVID-19 (HERO Trial)

Phase 3
Waitlist Available
Led By Bradley A Connor, MD
Research Sponsored by GeoSentinel Foundation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 90 days
Awards & highlights

HERO Trial Summary

This trial will test if taking hydroxychloroquine (HCQ) once a day can prevent COVID-19 infection in hospital workers. 374 workers will be given either HCQ or a placebo and followed for 90 days. The trial will compare the number of infected workers in each group.

Eligible Conditions
  • COVID-19
  • Prophylaxis
  • Coronavirus
  • Health Care Worker
  • Hydroxychloroquine

HERO Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~90 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 90 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Cumulative Incidence of COVID-19 Infection
Secondary outcome measures
Adverse events incidence
Days hospitalized attributed to COVID-19
Days of work lost
+3 more
Other outcome measures
Number of participants with severity markers of host immune and endothelial activation
Proportion of HCW with plasma able to neutralize SARS-CoV-2 virus

Side effects data

From 2021 Phase 4 trial • 93 Patients • NCT03122431
60%
Only sensory peripheral neuropathy
100%
80%
60%
40%
20%
0%
Study treatment Arm
SLE/Cutaneous Lupus With Thalidomide
Inactive SLE With Standard Dose of HCQ
Inactive SLE With Reduced Dose of HCQ

HERO Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Hydrocholoroquine Pre-exposure prophylaxisExperimental Treatment1 Intervention
HCQ will be administered as 400mg orally once for 60 days.
Group II: PlaceboPlacebo Group1 Intervention
Placebo will be administered as 400mg orally once for 60 days.

Find a Location

Who is running the clinical trial?

GeoSentinel FoundationLead Sponsor
Bradley A Connor, MDPrincipal InvestigatorDr. Bradley A. Connor

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
HEalth Care Worker pROphylaxis Against COVID-19: The HERO Trial
Bradley A. Connor, M.D. 2020. "HEalth Care Worker pROphylaxis Against COVID-19: The HERO Trial". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04352946.
All > Covid
~75 spots leftby Apr 2025
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