Lympathic Mapping with SPECT-CT guided Radiotherapy for Oropharyngeal Cancer

Phase-Based Progress Estimates
2
Effectiveness
3
Safety
University Health Network-Princess Margaret Cancer Centre, Toronto, CanadaOropharyngeal CancerLymphatic Mapping with SPECT-CT - Other
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trialis testing if using imaging to guide radiation therapy to one side of the neck can reduce risk of cancer returning or spreading.

Eligible Conditions
  • Oropharyngeal Cancer

Treatment Effectiveness

Effectiveness Progress

2 of 3
This is further along than 85% of similar trials

Study Objectives

1 Primary · 13 Secondary · Reporting Duration: 8 years

8 years
Disease-free Survival
Distant Metastases (DM)
Financial Toxicity [Financial Index of Toxicity (FIT)]
Gastrostomy Tube Usage
Health Utilities using EQ-5D
Incidence and Severity of Radiation-related Toxicities
Isolated contralateral neck failure (iCNF)
Logo-regional Failure (LRF)
Lost Productivity
Overall Survival (OS)
Patient-Reported Toxicities using PRO CTCAE
Quality of Life using M.D. Anderson Dysphagia Inventory (MDADI)
Resource Utilization
Xerostomia-related Quality of Life using Xerostomia Questionnaire (XQ)

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Trial Design

2 Treatment Groups

Bilateral Neck Radiotherapy
1 of 2
Lympathic Mapping with SPECT-CT guided Radiotherapy
1 of 2

Active Control

Experimental Treatment

510 Total Participants · 2 Treatment Groups

Primary Treatment: Lympathic Mapping with SPECT-CT guided Radiotherapy · No Placebo Group · Phase 3

Lympathic Mapping with SPECT-CT guided Radiotherapy
Other
Experimental Group · 1 Intervention: Lymphatic Mapping with SPECT-CT · Intervention Types: Other
Bilateral Neck Radiotherapy
Radiation
ActiveComparator Group · 1 Intervention: Ipsilateral and Contralateral Neck · Intervention Types: Radiation

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 8 years

Who is running the clinical trial?

Southwest Oncology GroupNETWORK
387 Previous Clinical Trials
262,443 Total Patients Enrolled
NRG OncologyOTHER
219 Previous Clinical Trials
95,090 Total Patients Enrolled
Canadian Cancer Trials GroupLead Sponsor
116 Previous Clinical Trials
65,332 Total Patients Enrolled
Alliance for Clinical Trials in OncologyOTHER
506 Previous Clinical Trials
216,960 Total Patients Enrolled
Eastern Cooperative Oncology GroupNETWORK
268 Previous Clinical Trials
149,388 Total Patients Enrolled
John R de AlmeidaStudy ChairUniversity Health Network, Princess Margaret Hospital, Toronto ON Canada
Ali HosniStudy ChairUniversity Health Network, Princess Margaret Hospital, Toronto ON Canada

Eligibility Criteria

Age 18+ · All Participants · 13 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have had or currently have another type of cancer, but it will not affect the safety or effectiveness of the treatment being studied.

Frequently Asked Questions

Has the FDA issued authorization for Lympathic Mapping with SPECT-CT guided Radiotherapy?

"There is prior clinical evidence that supports the saftey of Lympathic Mapping with SPECT-CT guided Radiotherapy, thus it was rated a 3 on our scale." - Anonymous Online Contributor

Unverified Answer

What is the enrollment size of this experiment?

"Affirmative. Clinicaltrials.gov has information that this research is currently recruiting, having been posted on September 29th 2022 and updated as recently as February 3rd 2023. The medical experiment seeks to enrol 510 participants from a single site." - Anonymous Online Contributor

Unverified Answer

Is enrollment into this experiment currently open to participants?

"Affirmative. As denoted on clinicaltrials.gov, this research was first made public in September 2022 and recently updated in February 2023. The study is enrolling 510 volunteers at a single site." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.