This trial is evaluating whether TPX-0131 will improve 3 primary outcomes and 12 secondary outcomes in patients with Solid Metastatic Tumor. Measurement will happen over the course of Up to 120 hours post-dose.
This trial requires 210 total participants across 1 different treatment group
This trial involves a single treatment. TPX-0131 is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.
"Cancer is a disease caused by genetic mutations that change how cells grow and make new cells. Patients can have many different types or stages of cancer, which can be hard to distinguish from a single problem. Cancer is also a disease which is often diagnosed too late, making sure that the right treatment is started for the optimal outcome." - Anonymous Online Contributor
"Many treatments used (e.g., drug therapy, massage therapy, massage, psychological counseling, and massage therapy) are unsupported, and should not be used. It is important that patients are aware of the lack of evidence for the effectiveness of these treatments." - Anonymous Online Contributor
"The seriousness of the disease and the lack of early intervention can be assessed. The high incidence and the large number of children and young adults that have and are getting cancer is a concern that justifies the necessity of early diagnosis and treatment." - Anonymous Online Contributor
"Signs of cancer occur in approximately 25% of children with cancer. This suggests that signs of cancer are more common in young children than older children or adults." - Anonymous Online Contributor
"Only 25% of survivors showed no signs of active disease. All patients with advanced [lung cancer](https://www.withpower.com/clinical-trials/lung-cancer) are candidates for palliative treatment, as survival is often short, especially when cancer has spread." - Anonymous Online Contributor
"In the majority of cases, the cause of cancer remains unknown. The cancer can be triggered by genetics, lifestyle behaviours, environment or viruses. The combination of cancer occurrence can be modulated by a number of risk factors. While most cancer cases can be accurately correlated to specific factors, others remain less obvious. It is important for health professionals to identify these factors to prevent and better treat cancer.\n" - Anonymous Online Contributor
"It is estimated that approximately 350,000 new cases of cancer of the skin will be diagnosed in the United States in 2006. Approximately 40,000 new bladder cancers will be diagnosed in 2006 in the United States. More than 20,000 people with colon cancer will die from the disease each year in the United States." - Anonymous Online Contributor
"The most frequent etiologies of carcinogenesis described in the literature are: 1. Viruses and associated mutagens; 2. Genetic predisposition to carcinoma, particularly inherited carcinoma; and 3. Other causes, namely radiation carcinoma, in addition to the three mentioned." - Anonymous Online Contributor
"Tpx-0131 is typically combined with conventional drugs as part of chemotherapy to treat patients with locally advanced or stage IV rectal cancer after surgery. However, studies of therapies with tpx-0131 alone or in combination with standard drugs are rare." - Anonymous Online Contributor
"Many stakeholders in clinical cancer research have concerns about the benefit-risk profile of clinical trials. These concerns are particularly salient in the context of late-stage cancers. In this paper, participants discuss how these concerns should inform clinical trial design and conduct, as well as clinical trial participation and communication." - Anonymous Online Contributor
"This Phase I clinical trial data on tpx-0131 for the treatment of solid tumors in patients with unresectable metastatic or locally advanced solid tumors was promising. The side effects experienced during this study were mostly mild and transient and were of mild to moderate severity. Further work to understand and improve the tolerability of this candidate drug is warranted." - Anonymous Online Contributor